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Definition of synchronous oligometastatic non–small cell lung cancer : a consensus report

(2019) JOURNAL OF THORACIC ONCOLOGY. 14(12). p.2109-2119
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Abstract
Introduction: Improved outcome has been shown in patients with synchronous oligometastatic (sOM) NSCLC when treated with radical intent. As a uniform definition of sOM NSCLC is lacking, we developed a definition and diagnostic criteria by a consensus process. Methods: A pan-European multidisciplinary consensus group was established. Consensus questions were built on the basis of current controversies, and definitions were extracted from a survey, cases and a systematic review. This statement was formulated during a consensus meeting. Results: It was determined that definition of sOM NSCLC is relevant when a radical treatment that may modify the disease course (leading to long-term disease control) is technically feasible for all tumor sites with acceptable toxicity. On the basis of the review, a maximum of five metastases and three organs was proposed. Mediastinal lymph node involvement was not counted as a metastatic site. Fludeoxyglucose F 18 positron emission tomography-computed tomography and brain imaging were considered mandatory. A dedicated liver magnetic resonance imaging scan was advised for a solitary liver metastasis, and thoracoscopy and biopsies of distant ipsilateral pleural sites were recommended for a solitary pleural metastasis. For mediastinal staging, fludeoxyglucose F 18 positron emission tomography-computed tomography was deemed the minimum requirement, with pathological confirmation recommended if this influences the treatment strategy. Biopsy of a solitary metastatic location was mandated unless the multidisciplinary team is of the opinion that the risks outweigh the benefits. Conclusion: A multidisciplinary consensus statement on the definition and staging of sOM NSCLC has been formulated. This statement will help to standardize inclusion criteria in future clinical trials. (C) 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
Keywords
Oncology, Pulmonary and Respiratory Medicine, Non-small cell lung cancer, Oligometastatic disease, Consensus definition, Staging, Non-small cell lung cancer, Oligometastatic disease, Consensus definition, Staging, ADRENAL METASTASES, PROGNOSTIC-FACTORS, RADICAL TREATMENT, PHASE-II, OUTCOMES, THERAPY, DISEASE, NSCLC, MULTICENTER, GUIDELINES

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MLA
Dingemans, Anne-Marie C., et al. “Definition of Synchronous Oligometastatic Non–Small Cell Lung Cancer : A Consensus Report.” JOURNAL OF THORACIC ONCOLOGY, vol. 14, no. 12, 2019, pp. 2109–19, doi:10.1016/j.jtho.2019.07.025.
APA
Dingemans, A.-M. C., Hendriks, L. E. L., Berghmans, T., Levy, A., Hasan, B., Faivre-Finn, C., … Novello, S. (2019). Definition of synchronous oligometastatic non–small cell lung cancer : a consensus report. JOURNAL OF THORACIC ONCOLOGY, 14(12), 2109–2119. https://doi.org/10.1016/j.jtho.2019.07.025
Chicago author-date
Dingemans, Anne-Marie C., Lizza E.L. Hendriks, Thierry Berghmans, Antonin Levy, Baktiar Hasan, Corinne Faivre-Finn, Matteo Giaj-Levra, et al. 2019. “Definition of Synchronous Oligometastatic Non–Small Cell Lung Cancer : A Consensus Report.” JOURNAL OF THORACIC ONCOLOGY 14 (12): 2109–19. https://doi.org/10.1016/j.jtho.2019.07.025.
Chicago author-date (all authors)
Dingemans, Anne-Marie C., Lizza E.L. Hendriks, Thierry Berghmans, Antonin Levy, Baktiar Hasan, Corinne Faivre-Finn, Matteo Giaj-Levra, Niccolò Giaj-Levra, Nicolas Girard, Laurent Greillier, Sylvie Lantuéjoul, John Edwards, Mary O’Brien, Martin Reck, Egbert F. Smit, Paul Van Schil, Pieter E. Postmus, Sara Ramella, Yolande Lievens, Mina Gaga, Nir Peled, Giorgio V. Scagliotti, Suresh Senan, Luiz Paz-Ares, Matthias Guckenberger, Fiona McDonald, Simon Ekman, Tanja Cufer, Hester Gietema, Maurizio Infante, Rafal Dziadziuszko, Solange Peters, Ramon Rami Porta, Johan Vansteenkiste, Christophe Dooms, Dirk de Ruysscher, Benjamin Besse, and Silvia Novello. 2019. “Definition of Synchronous Oligometastatic Non–Small Cell Lung Cancer : A Consensus Report.” JOURNAL OF THORACIC ONCOLOGY 14 (12): 2109–2119. doi:10.1016/j.jtho.2019.07.025.
Vancouver
1.
Dingemans A-MC, Hendriks LEL, Berghmans T, Levy A, Hasan B, Faivre-Finn C, et al. Definition of synchronous oligometastatic non–small cell lung cancer : a consensus report. JOURNAL OF THORACIC ONCOLOGY. 2019;14(12):2109–19.
IEEE
[1]
A.-M. C. Dingemans et al., “Definition of synchronous oligometastatic non–small cell lung cancer : a consensus report,” JOURNAL OF THORACIC ONCOLOGY, vol. 14, no. 12, pp. 2109–2119, 2019.
@article{8642014,
  abstract     = {{Introduction: Improved outcome has been shown in patients with synchronous oligometastatic (sOM) NSCLC when treated with radical intent. As a uniform definition of sOM NSCLC is lacking, we developed a definition and diagnostic criteria by a consensus process.

Methods: A pan-European multidisciplinary consensus group was established. Consensus questions were built on the basis of current controversies, and definitions were extracted from a survey, cases and a systematic review. This statement was formulated during a consensus meeting.

Results: It was determined that definition of sOM NSCLC is relevant when a radical treatment that may modify the disease course (leading to long-term disease control) is technically feasible for all tumor sites with acceptable toxicity. On the basis of the review, a maximum of five metastases and three organs was proposed. Mediastinal lymph node involvement was not counted as a metastatic site. Fludeoxyglucose F 18 positron emission tomography-computed tomography and brain imaging were considered mandatory. A dedicated liver magnetic resonance imaging scan was advised for a solitary liver metastasis, and thoracoscopy and biopsies of distant ipsilateral pleural sites were recommended for a solitary pleural metastasis. For mediastinal staging, fludeoxyglucose F 18 positron emission tomography-computed tomography was deemed the minimum requirement, with pathological confirmation recommended if this influences the treatment strategy. Biopsy of a solitary metastatic location was mandated unless the multidisciplinary team is of the opinion that the risks outweigh the benefits.

Conclusion: A multidisciplinary consensus statement on the definition and staging of sOM NSCLC has been formulated. This statement will help to standardize inclusion criteria in future clinical trials. (C) 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.}},
  author       = {{Dingemans, Anne-Marie C. and Hendriks, Lizza E.L. and Berghmans, Thierry and Levy, Antonin and Hasan, Baktiar and Faivre-Finn, Corinne and Giaj-Levra, Matteo and Giaj-Levra, Niccolò and Girard, Nicolas and Greillier, Laurent and Lantuéjoul, Sylvie and Edwards, John and O’Brien, Mary and Reck, Martin and Smit, Egbert F. and Van Schil, Paul and Postmus, Pieter E. and Ramella, Sara and Lievens, Yolande and Gaga, Mina and Peled, Nir and Scagliotti, Giorgio V. and Senan, Suresh and Paz-Ares, Luiz and Guckenberger, Matthias and McDonald, Fiona and Ekman, Simon and Cufer, Tanja and Gietema, Hester and Infante, Maurizio and Dziadziuszko, Rafal and Peters, Solange and Porta, Ramon Rami and Vansteenkiste, Johan and Dooms, Christophe and de Ruysscher, Dirk and Besse, Benjamin and Novello, Silvia}},
  issn         = {{1556-0864}},
  journal      = {{JOURNAL OF THORACIC ONCOLOGY}},
  keywords     = {{Oncology,Pulmonary and Respiratory Medicine,Non-small cell lung cancer,Oligometastatic disease,Consensus definition,Staging,Non-small cell lung cancer,Oligometastatic disease,Consensus definition,Staging,ADRENAL METASTASES,PROGNOSTIC-FACTORS,RADICAL TREATMENT,PHASE-II,OUTCOMES,THERAPY,DISEASE,NSCLC,MULTICENTER,GUIDELINES}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{2109--2119}},
  title        = {{Definition of synchronous oligometastatic non–small cell lung cancer : a consensus report}},
  url          = {{http://dx.doi.org/10.1016/j.jtho.2019.07.025}},
  volume       = {{14}},
  year         = {{2019}},
}

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