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Investigation of age-related differences in toxicokinetic processes of deoxynivalenol and deoxynivalenol-3-glucoside in weaned piglets

(2020) ARCHIVES OF TOXICOLOGY. 94(2). p.417-425
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Abstract
Age-related differences in toxicokinetic processes of deoxynivalenol (DON) and deoxynivalenol-3-glucoside (DON3G) were studied. DON3G [55.7 mu g/kg bodyweight (BW)] and an equimolar dose of DON (36 mu g/kg BW) were administered to weaned piglets (4 weeks old) by single intravenous and oral administration in a double two-way cross-over design. Systemic and portal blood was sampled at different time points pre- and post-administration and plasma concentrations of DON, DON3G and their metabolites were quantified using validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) and liquid chromatography-high-resolution mass spectrometry (LC-HRMS) methods. Data were processed using tailor-made compartmental toxicokinetic (TK) models to accurately estimate TK parameters. Results were statistically compared to data obtained in a previous study on 11-week-old pigs using identical experimental conditions. Significant age-related differences in intestinal and systemic exposure to both DON and DON3G were noted. Most remarkably, a significant difference was found for the absorbed fraction of DON3G, after presystemic hydrolysis to DON, in weaned piglets compared to 11-week-old piglets (83% vs 16%, respectively), assumed to be mainly attributed to the higher intestinal permeability of weaned piglets. Other differences in TK parameters could be assigned to a higher water/fat body ratio and longer gastrointestinal transit time of weaned piglets. Results may further refine current risk assessment concerning DON and DON3G in animals. Additionally, since piglets possibly serve as a human paediatric surrogate model, results may be extrapolated to human infants.
Keywords
Toxicology, Health, Mycotoxins, toxicokinetic, pig model, Deoxynivalenol, Deoxynivalenol-3-glucoside, Toxicokinetics, Pig, Weaning, Plasma protein binding, FUSARIUM TOXIN DEOXYNIVALENOL, MASKED MYCOTOXIN DEOXYNIVALENOL-3-GLUCOSIDE, CONTAMINATED WHEAT, METABOLISM, BIOAVAILABILITY, DON, CYTOTOXICITY, TOXICITY, EXPOSURE, MODEL

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MLA
Catteuw, Amelie, et al. “Investigation of Age-Related Differences in Toxicokinetic Processes of Deoxynivalenol and Deoxynivalenol-3-Glucoside in Weaned Piglets.” ARCHIVES OF TOXICOLOGY, vol. 94, no. 2, 2020, pp. 417–25.
APA
Catteuw, A., Devreese, M., De Baere, S., Antonissen, G., Ivanova, L., Uhlig, S., … Croubels, S. (2020). Investigation of age-related differences in toxicokinetic processes of deoxynivalenol and deoxynivalenol-3-glucoside in weaned piglets. ARCHIVES OF TOXICOLOGY, 94(2), 417–425.
Chicago author-date
Catteuw, Amelie, Mathias Devreese, Siegrid De Baere, Gunther Antonissen, Lada Ivanova, Silvio Uhlig, Ann Martens, Sarah De Saeger, Marthe De Boevre, and Siska Croubels. 2020. “Investigation of Age-Related Differences in Toxicokinetic Processes of Deoxynivalenol and Deoxynivalenol-3-Glucoside in Weaned Piglets.” ARCHIVES OF TOXICOLOGY 94 (2): 417–25.
Chicago author-date (all authors)
Catteuw, Amelie, Mathias Devreese, Siegrid De Baere, Gunther Antonissen, Lada Ivanova, Silvio Uhlig, Ann Martens, Sarah De Saeger, Marthe De Boevre, and Siska Croubels. 2020. “Investigation of Age-Related Differences in Toxicokinetic Processes of Deoxynivalenol and Deoxynivalenol-3-Glucoside in Weaned Piglets.” ARCHIVES OF TOXICOLOGY 94 (2): 417–425.
Vancouver
1.
Catteuw A, Devreese M, De Baere S, Antonissen G, Ivanova L, Uhlig S, et al. Investigation of age-related differences in toxicokinetic processes of deoxynivalenol and deoxynivalenol-3-glucoside in weaned piglets. ARCHIVES OF TOXICOLOGY. 2020;94(2):417–25.
IEEE
[1]
A. Catteuw et al., “Investigation of age-related differences in toxicokinetic processes of deoxynivalenol and deoxynivalenol-3-glucoside in weaned piglets,” ARCHIVES OF TOXICOLOGY, vol. 94, no. 2, pp. 417–425, 2020.
@article{8641750,
  abstract     = {{Age-related differences in toxicokinetic processes of deoxynivalenol (DON) and deoxynivalenol-3-glucoside (DON3G) were studied. DON3G [55.7 mu g/kg bodyweight (BW)] and an equimolar dose of DON (36 mu g/kg BW) were administered to weaned piglets (4 weeks old) by single intravenous and oral administration in a double two-way cross-over design. Systemic and portal blood was sampled at different time points pre- and post-administration and plasma concentrations of DON, DON3G and their metabolites were quantified using validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) and liquid chromatography-high-resolution mass spectrometry (LC-HRMS) methods. Data were processed using tailor-made compartmental toxicokinetic (TK) models to accurately estimate TK parameters. Results were statistically compared to data obtained in a previous study on 11-week-old pigs using identical experimental conditions. Significant age-related differences in intestinal and systemic exposure to both DON and DON3G were noted. Most remarkably, a significant difference was found for the absorbed fraction of DON3G, after presystemic hydrolysis to DON, in weaned piglets compared to 11-week-old piglets (83% vs 16%, respectively), assumed to be mainly attributed to the higher intestinal permeability of weaned piglets. Other differences in TK parameters could be assigned to a higher water/fat body ratio and longer gastrointestinal transit time of weaned piglets. Results may further refine current risk assessment concerning DON and DON3G in animals. Additionally, since piglets possibly serve as a human paediatric surrogate model, results may be extrapolated to human infants.}},
  author       = {{Catteuw, Amelie and Devreese, Mathias and De Baere, Siegrid and Antonissen, Gunther and Ivanova, Lada and Uhlig, Silvio and Martens, Ann and De Saeger, Sarah and De Boevre, Marthe and Croubels, Siska}},
  issn         = {{0340-5761}},
  journal      = {{ARCHIVES OF TOXICOLOGY}},
  keywords     = {{Toxicology,Health,Mycotoxins,toxicokinetic,pig model,Deoxynivalenol,Deoxynivalenol-3-glucoside,Toxicokinetics,Pig,Weaning,Plasma protein binding,FUSARIUM TOXIN DEOXYNIVALENOL,MASKED MYCOTOXIN DEOXYNIVALENOL-3-GLUCOSIDE,CONTAMINATED WHEAT,METABOLISM,BIOAVAILABILITY,DON,CYTOTOXICITY,TOXICITY,EXPOSURE,MODEL}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{417--425}},
  title        = {{Investigation of age-related differences in toxicokinetic processes of deoxynivalenol and deoxynivalenol-3-glucoside in weaned piglets}},
  url          = {{http://dx.doi.org/10.1007/s00204-019-02644-x}},
  volume       = {{94}},
  year         = {{2020}},
}

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