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Cardiovascular, respiratory, gastrointestinal and behavioral effects of intravenous lidocaine in healthy, conscious horses and evaluation of the relationship with lidocaine and monoethylglycinexylidide serum concentrations

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Abstract
This study aimed to evaluate the relationship between the serum concentrations of lidocaine/ monoethylglycinexylidide (MEGX) and their effects on several systems in horses. Five healthy, conscious horses received a two-hour placebo intravenous infusion followed by a two-hour lidocaine infusion (bolus of 1.3 mg/kg over ten minutes followed by a continuous rate infusion of 0.05 mg/kg/min). Lidocaine and MEGX serum concentrations were sampled every ten to fifteen minutes during the experiment, and the presence of muscle fasciculations and loss of balance as well as the respiratory, digestive and cardiovascular systems of the five horses were evaluated by means of different non-invasive methods. During the lidocaine infusion, the mean (f SD) lidocaine and MEGX concentrations were respectively 768.88 +/- 93.32ng/ml and 163.08 +/- 108.98 ng/ml. The infusion of lidocaine significantly influenced the presence of fasciculations, caused a statistically but non-clinically significant decrease of systolic and diastolic blood pressures, which were both correlated with lidocaine and MEGX serum concentrations, and it increased the duodenal contractions frequency, which was correlated with the serum lidocaine concentration. In this study, mild hypotensive and prokinetic effects of short-term lidocaine infusion were observed.
Keywords
BLOOD-PRESSURE, SMOOTH-MUSCLE, CONTINUOUS-INFUSION, PHARMACOKINETICS, METABOLITES, ULTRASONOGRAPHY, CONTRACTILITY, ERYTHROMYCIN, LIGNOCAINE, TOXICITY

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MLA
Salciccia, A., et al. “Cardiovascular, Respiratory, Gastrointestinal and Behavioral Effects of Intravenous Lidocaine in Healthy, Conscious Horses and Evaluation of the Relationship with Lidocaine and Monoethylglycinexylidide Serum Concentrations.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, vol. 88, no. 2, 2019, pp. 67–76.
APA
Salciccia, A., Lopez Arevalo, D., Maes, A., Croubels, S., Busoni, V., Detilleux, J., … Amory, H. (2019). Cardiovascular, respiratory, gastrointestinal and behavioral effects of intravenous lidocaine in healthy, conscious horses and evaluation of the relationship with lidocaine and monoethylglycinexylidide serum concentrations. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 88(2), 67–76.
Chicago author-date
Salciccia, A, DM Lopez Arevalo, An Maes, Siska Croubels, V Busoni, J Detilleux, C Sandersen, and H Amory. 2019. “Cardiovascular, Respiratory, Gastrointestinal and Behavioral Effects of Intravenous Lidocaine in Healthy, Conscious Horses and Evaluation of the Relationship with Lidocaine and Monoethylglycinexylidide Serum Concentrations.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 88 (2): 67–76.
Chicago author-date (all authors)
Salciccia, A, DM Lopez Arevalo, An Maes, Siska Croubels, V Busoni, J Detilleux, C Sandersen, and H Amory. 2019. “Cardiovascular, Respiratory, Gastrointestinal and Behavioral Effects of Intravenous Lidocaine in Healthy, Conscious Horses and Evaluation of the Relationship with Lidocaine and Monoethylglycinexylidide Serum Concentrations.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 88 (2): 67–76.
Vancouver
1.
Salciccia A, Lopez Arevalo D, Maes A, Croubels S, Busoni V, Detilleux J, et al. Cardiovascular, respiratory, gastrointestinal and behavioral effects of intravenous lidocaine in healthy, conscious horses and evaluation of the relationship with lidocaine and monoethylglycinexylidide serum concentrations. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2019;88(2):67–76.
IEEE
[1]
A. Salciccia et al., “Cardiovascular, respiratory, gastrointestinal and behavioral effects of intravenous lidocaine in healthy, conscious horses and evaluation of the relationship with lidocaine and monoethylglycinexylidide serum concentrations,” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, vol. 88, no. 2, pp. 67–76, 2019.
@article{8641742,
  abstract     = {{This study aimed to evaluate the relationship between the serum concentrations of lidocaine/ monoethylglycinexylidide (MEGX) and their effects on several systems in horses. Five healthy, conscious horses received a two-hour placebo intravenous infusion followed by a two-hour lidocaine infusion (bolus of 1.3 mg/kg over ten minutes followed by a continuous rate infusion of 0.05 mg/kg/min). Lidocaine and MEGX serum concentrations were sampled every ten to fifteen minutes during the experiment, and the presence of muscle fasciculations and loss of balance as well as the respiratory, digestive and cardiovascular systems of the five horses were evaluated by means of different non-invasive methods. During the lidocaine infusion, the mean (f SD) lidocaine and MEGX concentrations were respectively 768.88 +/- 93.32ng/ml and 163.08 +/- 108.98 ng/ml. The infusion of lidocaine significantly influenced the presence of fasciculations, caused a statistically but non-clinically significant decrease of systolic and diastolic blood pressures, which were both correlated with lidocaine and MEGX serum concentrations, and it increased the duodenal contractions frequency, which was correlated with the serum lidocaine concentration. In this study, mild hypotensive and prokinetic effects of short-term lidocaine infusion were observed.}},
  author       = {{Salciccia, A and Lopez Arevalo, DM and Maes, An and Croubels, Siska and Busoni, V and Detilleux, J and Sandersen, C and Amory, H}},
  issn         = {{0303-9021}},
  journal      = {{VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT}},
  keywords     = {{BLOOD-PRESSURE,SMOOTH-MUSCLE,CONTINUOUS-INFUSION,PHARMACOKINETICS,METABOLITES,ULTRASONOGRAPHY,CONTRACTILITY,ERYTHROMYCIN,LIGNOCAINE,TOXICITY}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{67--76}},
  title        = {{Cardiovascular, respiratory, gastrointestinal and behavioral effects of intravenous lidocaine in healthy, conscious horses and evaluation of the relationship with lidocaine and monoethylglycinexylidide serum concentrations}},
  volume       = {{88}},
  year         = {{2019}},
}

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