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Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives

(2019) MONATSHEFTE FUR CHEMIE. 150(12). p.2045-2051
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Abstract
A small set of structurally different monocarbonyl curcuminoids was prepared and screened for cytotoxic activity. In particular, bis-3-methoxy-4-hydroxy- and bis-4-methoxyphenyl-substituted monocarbonyls were synthesized and transformed into the corresponding three-dimensional N-acetylpyrazoline derivatives. In addition, a non-symmetrical indole-based monocarbonyl curcumin was prepared as well. Preliminary cytotoxic evaluation revealed significant effects for 4-hydroxy (pyrazoline) monocarbonyl curcuminoids, whereas the non-phenolic variants displayed rather poor activity. Graphic abstract
Keywords
General Chemistry, Aldol reactions, Antitumor agents, Curcumin, Heterocycles, Real-time proliferation assay, MONO-CARBONYL ANALOGS, IN-VITRO, STRESS

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MLA
Van de Walle, Tim, et al. “Synthesis and Cytotoxic Evaluation of Monocarbonyl Curcuminoids and Their Pyrazoline Derivatives.” MONATSHEFTE FUR CHEMIE, vol. 150, no. 12, 2019, pp. 2045–51, doi:10.1007/s00706-019-02516-1.
APA
Van de Walle, T., Theppawong, A., Grootaert, C., De Jonghe, S., Persoons, L., Daelemans, D., … D’hooghe, M. (2019). Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives. MONATSHEFTE FUR CHEMIE, 150(12), 2045–2051. https://doi.org/10.1007/s00706-019-02516-1
Chicago author-date
Van de Walle, Tim, Atiruj Theppawong, Charlotte Grootaert, Steven De Jonghe, Leentje Persoons, Dirk Daelemans, Kristof Van Hecke, John Van Camp, and Matthias D’hooghe. 2019. “Synthesis and Cytotoxic Evaluation of Monocarbonyl Curcuminoids and Their Pyrazoline Derivatives.” MONATSHEFTE FUR CHEMIE 150 (12): 2045–51. https://doi.org/10.1007/s00706-019-02516-1.
Chicago author-date (all authors)
Van de Walle, Tim, Atiruj Theppawong, Charlotte Grootaert, Steven De Jonghe, Leentje Persoons, Dirk Daelemans, Kristof Van Hecke, John Van Camp, and Matthias D’hooghe. 2019. “Synthesis and Cytotoxic Evaluation of Monocarbonyl Curcuminoids and Their Pyrazoline Derivatives.” MONATSHEFTE FUR CHEMIE 150 (12): 2045–2051. doi:10.1007/s00706-019-02516-1.
Vancouver
1.
Van de Walle T, Theppawong A, Grootaert C, De Jonghe S, Persoons L, Daelemans D, et al. Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives. MONATSHEFTE FUR CHEMIE. 2019;150(12):2045–51.
IEEE
[1]
T. Van de Walle et al., “Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives,” MONATSHEFTE FUR CHEMIE, vol. 150, no. 12, pp. 2045–2051, 2019.
@article{8641514,
  abstract     = {A small set of structurally different monocarbonyl curcuminoids was prepared and screened for cytotoxic activity. In particular, bis-3-methoxy-4-hydroxy- and bis-4-methoxyphenyl-substituted monocarbonyls were synthesized and transformed into the corresponding three-dimensional N-acetylpyrazoline derivatives. In addition, a non-symmetrical indole-based monocarbonyl curcumin was prepared as well. Preliminary cytotoxic evaluation revealed significant effects for 4-hydroxy (pyrazoline) monocarbonyl curcuminoids, whereas the non-phenolic variants displayed rather poor activity. Graphic abstract},
  author       = {Van de Walle, Tim and Theppawong, Dr. Atiruj and Grootaert, Charlotte and De Jonghe, Steven and Persoons, Leentje and Daelemans, Dirk and Van Hecke, Kristof and Van Camp, John and D'hooghe, Matthias},
  issn         = {0026-9247},
  journal      = {MONATSHEFTE FUR CHEMIE},
  keywords     = {General Chemistry,Aldol reactions,Antitumor agents,Curcumin,Heterocycles,Real-time proliferation assay,MONO-CARBONYL ANALOGS,IN-VITRO,STRESS},
  language     = {eng},
  number       = {12},
  pages        = {2045--2051},
  title        = {Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives},
  url          = {http://dx.doi.org/10.1007/s00706-019-02516-1},
  volume       = {150},
  year         = {2019},
}

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