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Accelerated hermeticity testing of biocompatible moisture barriers used for the encapsulation of implantable medical devices

Changzheng Li (UGent) , Maarten Cauwe (UGent) , Lothar Mader (UGent) , David Schaubroeck (UGent) and Maaike Op de Beeck (UGent)
(2020) COATINGS. 10(1).
Author
Organization
Abstract
Barrier layers for the long-term encapsulation of implantable medical devices play a crucial role in the devices’ performance and reliability. Typically, to understand the stability and predict the lifetime of barriers (therefore, the implantable devices), the device is subjected to accelerated testing at higher temperatures compared to its service parameters. Nevertheless, at high temperatures, reaction and degradation mechanisms might be different, resulting in false accelerated test results. In this study, the maximum valid temperatures for the accelerated testing of two barrier layers were investigated: atomic layer deposited (ALD) Al2O3 and stacked ALD HfO2/Al2O3/HfO2, hereinafter referred to as ALD-3. The in-house developed standard barrier performance test is based on continuous electrical resistance monitoring and microscopic inspection of Cu patterns covered with the barrier and immersed in phosphate buffered saline (PBS) at temperatures up to 95 °C. The results demonstrate the valid temperature window to perform temperature acceleration tests. In addition, the optimized ALD layer in combination with polyimide (polyimide/ALD-3/polyimide) works as effective barrier at 60 °C for 1215 days, suggesting the potential applicability to the encapsulation of long-term implants.
Keywords
temperature acceleration test, valid temperature window, moisture barrier, biocompatible encapsulation, ALD HfO2/Al2O3/HfO2, polyimide, ATOMIC LAYER DEPOSITION, POLYMERIC BIOMATERIALS, PARYLENE C, AL2O3, FILMS, PERFORMANCE, ALUMINA, PERMEATION, SOLUBILITY, POLYIMIDE

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MLA
Li, Changzheng, et al. “Accelerated Hermeticity Testing of Biocompatible Moisture Barriers Used for the Encapsulation of Implantable Medical Devices.” COATINGS, vol. 10, no. 1, 2020, doi:10.3390/coatings10010019.
APA
Li, C., Cauwe, M., Mader, L., Schaubroeck, D., & Op de Beeck, M. (2020). Accelerated hermeticity testing of biocompatible moisture barriers used for the encapsulation of implantable medical devices. COATINGS, 10(1). https://doi.org/10.3390/coatings10010019
Chicago author-date
Li, Changzheng, Maarten Cauwe, Lothar Mader, David Schaubroeck, and Maaike Op de Beeck. 2020. “Accelerated Hermeticity Testing of Biocompatible Moisture Barriers Used for the Encapsulation of Implantable Medical Devices.” COATINGS 10 (1). https://doi.org/10.3390/coatings10010019.
Chicago author-date (all authors)
Li, Changzheng, Maarten Cauwe, Lothar Mader, David Schaubroeck, and Maaike Op de Beeck. 2020. “Accelerated Hermeticity Testing of Biocompatible Moisture Barriers Used for the Encapsulation of Implantable Medical Devices.” COATINGS 10 (1). doi:10.3390/coatings10010019.
Vancouver
1.
Li C, Cauwe M, Mader L, Schaubroeck D, Op de Beeck M. Accelerated hermeticity testing of biocompatible moisture barriers used for the encapsulation of implantable medical devices. COATINGS. 2020;10(1).
IEEE
[1]
C. Li, M. Cauwe, L. Mader, D. Schaubroeck, and M. Op de Beeck, “Accelerated hermeticity testing of biocompatible moisture barriers used for the encapsulation of implantable medical devices,” COATINGS, vol. 10, no. 1, 2020.
@article{8640552,
  abstract     = {Barrier layers for the long-term encapsulation of implantable medical devices play a crucial role in the devices’ performance and reliability. Typically, to understand the stability and predict the lifetime of barriers (therefore, the implantable devices), the device is subjected to accelerated testing at higher temperatures compared to its service parameters. Nevertheless, at high temperatures, reaction and degradation mechanisms might be different, resulting in false accelerated test results. In this study, the maximum valid temperatures for the accelerated testing of two barrier layers were investigated: atomic layer deposited (ALD) Al2O3 and stacked ALD HfO2/Al2O3/HfO2, hereinafter referred to as ALD-3. The in-house developed standard barrier performance test is based on continuous electrical resistance monitoring and microscopic inspection of Cu patterns covered with the barrier and immersed in phosphate buffered saline (PBS) at temperatures up to 95 °C. The results demonstrate the valid temperature window to perform temperature acceleration tests. In addition, the optimized ALD layer in combination with polyimide (polyimide/ALD-3/polyimide) works as effective barrier at 60 °C for 1215 days, suggesting the potential applicability to the encapsulation of long-term implants.},
  articleno    = {19},
  author       = {Li, Changzheng and Cauwe, Maarten and Mader, Lothar and Schaubroeck, David and Op de Beeck, Maaike},
  issn         = {2079-6412},
  journal      = {COATINGS},
  keywords     = {temperature acceleration test,valid temperature window,moisture barrier,biocompatible encapsulation,ALD HfO2/Al2O3/HfO2,polyimide,ATOMIC LAYER DEPOSITION,POLYMERIC BIOMATERIALS,PARYLENE C,AL2O3,FILMS,PERFORMANCE,ALUMINA,PERMEATION,SOLUBILITY,POLYIMIDE},
  language     = {eng},
  number       = {1},
  pages        = {14},
  title        = {Accelerated hermeticity testing of biocompatible moisture barriers used for the encapsulation of implantable medical devices},
  url          = {http://dx.doi.org/10.3390/coatings10010019},
  volume       = {10},
  year         = {2020},
}

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