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Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

(2019) AMERICAN JOURNAL OF NEPHROLOGY. 50(5). p.345-356
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Abstract
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
Keywords
WORSENING RENAL-FUNCTION, CHRONIC HEART-FAILURE, MINERALOCORTICOID, RECEPTOR, BAY 94-8862, SPIRONOLACTONE, ANTAGONIST, RISK, EFFICACY, MILD, COMPLICATIONS, Kidney, Mineralocorticoid, Diabetes, Aldosterone, Outcomes, Clinical

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MLA
Ruilope, Luis M., et al. “Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial.” AMERICAN JOURNAL OF NEPHROLOGY, vol. 50, no. 5, 2019, pp. 345–56.
APA
Ruilope, L. M., Agarwal, R., Anker, S. D., Bakris, G. L., Filippatos, G., Nowack, C., … Lan Phuong Tran, L. P. T. (2019). Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial. AMERICAN JOURNAL OF NEPHROLOGY, 50(5), 345–356.
Chicago author-date
Ruilope, Luis M., Rajiv Agarwal, Stefan D. Anker, George L. Bakris, Gerasimos Filippatos, Christina Nowack, Peter Kolkhof, et al. 2019. “Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial.” AMERICAN JOURNAL OF NEPHROLOGY 50 (5): 345–56.
Chicago author-date (all authors)
Ruilope, Luis M., Rajiv Agarwal, Stefan D. Anker, George L. Bakris, Gerasimos Filippatos, Christina Nowack, Peter Kolkhof, Amer Joseph, Nicole Mentenich, Bertram Pitt, Diego Aizenberg, Ines Bartolacci, Diego Besada, Julio Bittar, Mariano Chahin, Alicia Elbert, Elizabeth Gelersztein, Alberto Liberman, Laura Maffei, Federico Perez Manghi, Hugo Sanabria, Augusto Vallejos, Gloria Vines, Alfredo Wassermann, Walter Abhayaratna, Peter Colman, David Colquhon, Elif Ekinci, Richard MacIsaac, Peak Mann Mah, Craig Nelson, David Packham, Alexia Pape, Simon Roger, Hugo Stephenson, Michael Suranyi, Duncan Topliss, James Vandeleur, Gary Wittert, Katie-Jane Wynne, Martin Clodi, Heinz Drexel, Christoph Ebenbichler, Evelyn Fliesser-Goerzer, Ursula Hanusch, Bernhard Ludvik, Peter Neudorfer, Bernhard Paulweber, Rudolf Prager, Wolfgang Preiss, Friedrich Prischl, Gerit-Holger Schernthaner, Hans-Robert Schoenherr, Harald Sourij, Peter Doubel, Francis Duyck, Wendy Engelen, Pieter Gillard, Jean-Michel Hougardy, Andre Scheen, Marijn Speeckaert, Koen Stas, Luc van Gaal, Hilde Vanbelleghem, Daniela Antunes, Roberto Botelho, Claudia Brito, Luis Canani, Maria Eugenia Canziani, Maria Cerqueira, Rogerio de Paula, Freddy Eliaschewitz, Carlos Eduardo Figueiredo, Adriana Forti, Miguel Hissa, Jr. Leite, Maurilo, Irene Noronha, Bruno Paolino, Nathalia Paschoalin, Raphael Paschoalin, Roberto Pecoits Filho, Marcio Pereira, Evandro Portes, Dalton Precoma, Rosangela Rea, Miguel Riella, Joao Eduardo Salles, Eduardo Vasconcellos, Sergio Vencio, Radostina Boshnyashka, Ghassan Farah, Dimitar Georgiev, Valentina Gushterova, Neli Klyuchkova, Mariya Lucheva, Petya Manova, Dotska Minkova, Boyan Nonchev, Mariyana Pichmanova, Zhulieta Prakova, Rangel Rangelov, Rosen Rashkov, Pavel Stanchev, Bilyana Stoyanovska-Elencheva, Zhivko Tagarev, Theodora Temelkova-Kurktschieva, Svetla Vasileva, Mariana Yoncheva-Mihaylova, Paul Barre, Brian Carlson, James Conway, Serge Cournoyer, Richard Dumas, Sameh Fikry, Richard Goluch, Pavel Hamet, Randolph Hart, Sam Henein, Allan Kelly, Joanne Liutkus, Francois Madore, Valdemar Martinho, Giuseppe Mazza, Philip McFarlane, Dennis O’Keefe, Sean Peterson, Daniel Schwartz, Daniel Shu, Andrew Steele, Ivor Teitelbaum, Guy Tellier, Karthik Tennankore, Sheldon Tobe, George Tsoukas, Richard Tytus, Louise Vitou, Michael Walsh, Stanley Weisnagel, Igor Wilderman, Jean-Francois Yale, Jorge Cobos, Juan Godoy, Fernando Gonzalez, Marcelo Medina, Juan Carlos Palma, Juan Carlos Prieto, Eliana Reyes, Carmen Romero, Victor Saavedra, Paola Varleta, Ruifang Bu, Hanqing Cai, Nan Chen, Qinkai Chen, Dejun Chen, Jinluo Cheng, Youping Dong, Junwu Dong, Yuming Du, Yi Fang, Tianjun Guan, Weiying Guo, Chuanming Hao, Fangfang Jiang, Sheng Jian, Jian Kuang, Minxiang Lei, Ling Li, Dongmei Li, Hongmei Li, Jingmei Li, Yan Li, Yuxiu Li, Zhonghe Li, Fang Liu, Juan Liu, Yinghong Liu, Yuantao Liu, Zhihong Liu, Gang Long, Guoyuan Lu, Weiping Lu, Yibing Lu, Jianhua Ma, Zhaohui Mo, Jianying Niu, Ai Peng, Jiansong Shen, Feixia Shen, Bingyin Shi, Qing Su, Zhuxing Sun, Shuifu Tang, Nanwei Tong, Hao Wang, Xinjun Wang, Lihua Wang, Jianqin Wang, Li Wang, Jiali Wei, Chaoqing Wu, Tianfeng Wu, Changying Xing, Fei Xiong, Xudong Xu, Ning Xu, Jinkui Yang, Aiping Yin, Longyi Zeng, Hao Zhang, Yanlin Zhang, Ying Zhang, Zhiquan Zhao, Hongguang Zheng, Ling Zhong, Liyong Zhong, Dalong Zhu, Clara Arango, Edgar Arcos, Gustavo Arcos, Sandra Barrera, German Barreto, Nelly Beltran Lopez, Diego Benitez, Guillermo Blanco, Rodrigo Botero, Tatiana Cardenas, Julian Coronel, Carlos Cure, Carlos Duran, Luis Garcia, Gustavo Guzman, Eric Hernandez, Jaime Ibarra, Carlos Jaramillo, Nicolas Jaramillo, William Kattah, Dora Molina, Gregorio Sanchez, Monica Terront, Freddy Trujillo, Miguel Urina, Ivan Villegas, Hernan Yupanqui, Dino Alferi, Michal Brada, Jiri Brezina, Petr Bucek, Tomas Edelsberger, Drahomira Gulakova, Jitka Hasalova Zapletalova, Olga Hola, Lucie Hornova, Jana Houdova, Helena Hrmova, David Karasek, Sarka Kopecka, Richard Kovar, Eva Krcova, Jiri Kuchar, Vlasta Kutejova, Hana Lubanda, Ivo Matyasek, Magdalena Mokrejsova, Libor Okenka, Martin Prazny, Jiri Pumprla, Pavel Tomanek, Jesper Bech, Jens Faber, Gunnar Gislason, Jorgen Hangaard, Grzegorz Jaroslaw Pacyk, Claus Juhl, Thure Krarup, Morten Lindhardt, Sten Madsbad, Joan Nielsen, Ulrik Pedersen-Bjergaard, Per Poulsen, Ole Rasmussen, Peter Rossing, Karoline Schousboe, Mikko Honkasalo, Kari Humaloja, Kristiina Kananen, Ilkka Kantola, Arvo Koistinen, Pirkko Korsoff, Jorma Lahtela, Sakari Nieminen, Tuomo Nieminen, Karita Sadeharju, Jorma Strand, Sakari Sulosaari, Bertrand Cariou, FranOois Chantrel, Sylvaine Clavel, Jean-Pierre Fauvel, Karim Gallouj, Didier Gouet, Bruno Guerci, Dominique Guerrot, Alexandre Klein, Yannick Le Meur, Rafik Mesbah, Arnaud Monier, Olivier Moranne, Ronan Roussel, Pierre Serusclat, Bruno Verges, Philippe Zaoui, Christoph Axthelm, Andreas Birkenfeld, Hermann Braun, Klaus Busch, Christel Contzen, Stefan Degenhardt, Karl Derwahl, Thomas Giebel, Andreas Hagenow, Hermann Haller, 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Winkelmann, Ioannis Boletis, Erifili Hatziagelaki, Ioannis Ioannidis, Theodora Kounadi, Ioanna Makriniotou, Dorothea Papadopoulou, Aikaterini Papagianni, Ploumis Passadakis, Ioannis Stefanidis, Tai Pang Ip, Paul Lee, Ching Wan Ronald Ma, Vincent Yeung, Dora Bajcsi, Peter Danos, Eleonora Harcsa, Akos Kalina, Szilvia Kazup, Katalin Keltai, Robert Kirschner, Julianna Kiss, Laszlo Kovacs, Beata Lamboy, Botond Literati-Nagy, Margit Mileder, Laszlo Nagy, Ebrahim Noori, Gabor Nyirati, Gizella Petro, Karoly Schneider, Albert Szocs, Szilard Vasas, Krisztina Wudi, Zsolt Zilahi, Marianna Zsom, Joe Eustace, Mensud Hatunic, John Holian, Donal Reddan, Yvonne O’Meara, Rosane Abramof Ness, Faiad Adawi, Zaher Armaly, Shaul Atar, Amir Bashkin, Sydney Ben Chetrit, Noa Berar Yanay, Gil Chernin, Mahmud Darawsha, Shai Efrati, Mazen Elias, Evgeny Farber, Mariela Glandt, Ehud Grossman, Majdi Halabi, Idit Liberty, Ofri Mosenzon, Assy Nimer, Doron Schwartz, Julio Wainstein, Yoram Yagil, Robert Zukermann, Giovanni Giorgio Battaglia, Enzo Bonora, Carlo Antonio Bossi, Paolo Calabro, Franco Luigi Cavalot, Roberto Cimino, Michele Emdin, Enrico Fiaccadori, Paolo Fiorina, Carlo Bruno Giorda, Maria Cristina Gregorini, Gaetano La Manna, Davide Carlo Maggi, Antonello Pani, Norberto Perico, PierMarco Piatti, Antonio Pisani, Paola Ponzani, Gennaro Santorelli, Domenico Santoro, Giancarlo Tonolo, Roberto Trevisan, Anna Maria Veronelli, Hideo Araki, Osamu Ebisui, Naruhiro Fujita, Ryuichi Furuya, Yoshiyuki Hamamoto, Masahiro Hatazaki, Terumasa Hayashi, Takayuki Higashi, Yoshihide Hirohata, Shuji Horinouchi, Hirofumi Imoto, Akemi Inagaki, Masayuki Inagaki, Masao Ishii, Tamayo Ishiko, Hideaki Jinnouchi, Hidetoshi Kanai, Daisuke Kanda, Hideo Kanehara, Masayuki Kashima, Kiyoe Kato, Takeshi Katsuki, Katsunori Kawamitsu, Satsuki Kawasaki, Fumi Kikuchi, Hidetoshi Kikuchi, Kunihisa Kobayashi, Junko Koide, Miyuki Kubota, Yoshiro Kusano, Hajime Maeda, Sunao Matsubayashi, Kazunari Matsumoto, Yasuto Matsuo, Naoki Matsuoka, Hiroaki Miyaoka, Satoshi Murao, Mikihiro Nakayama, Jun Nakazawa, Takashi Nomiyama, Masayuki Noritake, Takayuki Ogiwara, Hiroshi Ohashi, Hideki Okamoto, Takeshi Osonoi, Nobuhiro Sasaki, Taiji Sekigami, Taro Shibasaki, Hirotaka Shibata, Junji Shinoda, Hiroshi Sobajima, Kazuya Sugitatsu, Toshiyuki Sugiura, Toru Sugiyama, Daisuke Suzuki, Masaaki Suzuki, Asami Tanaka, Seiichi Tanaka, Izumi Tsunematsu, Makoto Ujihara, Daishiro Yamada, Masayo Yamada, Kazuo Yamagata, Fumiko Yamakawa, Ken Yamakawa, Yoshimitsu Yamasaki, Yuko Yambe, Hidekatsu Yanai, Tetsuyuki Yasuda, Dovile Kriauciuniene, Jurate Lasiene, Antanas Navickas, Lina Radzeviciene, Egle Urbanaviciene, Gediminas Urbonas, Audrone Velaviciene, Nor Azizah Aziz, Li Yuan Lee, Chek Loong Loh, Masni Mohamad, Norhaliza Mohd Ali, Rizmy Najme Khir, Nik Nur Fatnoon Nik Ahmad, Jeyakantha Ratnasingam, Wan Hasnul Halimi Bin Wan Hasan, Wan Mohd Izani Wan Mohamed, Melchor Alpizar Salazar, Sandro Avila Pardo, Miriam Bastidas Adrian, Alfredo Chew Wong, Jorge Escobedo de la Pe a, Guillermo Fanghanel Salmon, Pedro Garc-a Hernandez, Guillermo Gonzalez Galvez, Jose Gonzalez Gonzalez, Ramiro Gutierrez Ochoa, Saul Irizar Santana, Jose Lazcano Soto, Magdalena Madero Rovalo, Gustavo Mendez Machado, Luis Nevarez Ruiz, Gabriel Ramos Lopez, Arturo Saldana Mendoza, Leobardo Sauque Reyna, Gustavo Solache Ortiz, Rafael Valdez Ortiz, Juan Villagordoa Mesa, R. C. Bakker, J. N. M. Barendregt, A. H. Boonstra, C. B. Brouwer, M. van Buren, Ron Gansevoort, Adriaan Kooy, Marielle Krekels, Ruud J. M. van Leendert, Louis A. G. Lieverse, P. T. Luik, E. Lars Penne, Bert-Jan van den Born, Liffert Vogt, John Baker, Veronica Crawford, Rick Cutfield, Peter Dunn, Jeremy Krebs, Kingsley Nirmalaraj, Russell Scott, Nine Smuts, Emil Asprusten, Erik Eriksen, Trine Finnes, Robert Hagemeier, Hans Hoivik, Thomas Karlsson, Knut Risberg, Jan Rocke, Hilde Selsas, Leidulv Solnor, Frode Thorup, Albert Bautista, Elizabeth Catindig, Roberto Mirasol, Glenda Pamugas, Maribel Tanque, Louie Tirador, Patrycja Butrymowicz, Kazimierz Ciechanowski, Grazyna Cieslik, Edward Franek, Janusz Gumprecht, Michal Hoffmann, Jolanta Krzykowska, Ilona Kurnatowska, Katarzyna Landa, Adam Madrzejewski, Katarzyna Madziarska, Stanislaw Mazur, Piotr Napora, Michal Nowicki, Anna Ocicka-Kozakiewicz, Barbara Rewerska, Teresa Rusicka, Jan Ruxer, Ewa Skokowska, Andrzej Stankiewicz, Tomasz Stompor, Agnieszka Tiuryn-Petrulewicz, Katarzyna Wasilewska, Bogna Wierusz-Wysocka, Renata Wnetrzak-Michalska, Edgar Almeida, Rosa Ballesteros, Carlos Barreto, Ilidio Brandao, Rui Carvalho, Cesar Esteves, Jose Guia, Susana Heitor, Pedro Matos, Pedro Melo, Fernando Nolasco, Amalia Pereira, Cristina Roque, Francisco Rosario, Gil Silva, Ana Silva, Fernando Teixeira e Costa, Ana Vila Lobos, Gregorio Cortes-Maisonet, Amaury Roman-Miranda, Adrian Albota, Cornelia Bala, Hortensia Barbonta, Elena Caceaune, Doina Catrinoui, Ciprian Constantin, Adriana Dumitrescu, Nicoleta Mindrescu, Cristina Mistode, Gabriela Negrisanu, Adriana Onaca, Silvia Paveliu, Ella Pintilei, Lavinia Pop, Amorin Popa, Alexandrina Popescu, Gabriela Radulian, Iosif Szilagyi, Liana Turcu, Georgeta Vacaru, Adrian Vlad, Mikhail Antsiferov, Mikhail Arkhipov, Andrey Babkin, Vitaliy Baranov, Olga Barbarash, Elena Chernyavskaya, Arkadiy Demko, Alexander Dreval, Anton Edin, Polina Ermakova, Albert Galyavich, Leyla Gaysina, Ivan Gordeev, Irina Ipatko, Marina Kalashnikova, Yuriy Khalimov, Vadim Klimontov, Zhanna Kobalava, Elena Kosmacheva, Natalya Koziolova, Lyudmila Kvitkova, Sergey Levashov, Roman Libis, Natalia Malykh, Sofya Malyutina, Vyacheslav Marasaev, Vyacheslav Mareev, Vladimir Martynenko, Imad Merai, Ashot Mkrtumyan, Galina Nechaeva, Konstantin Nikolaev, Shamil Palyutin, Nina Petunina, Leonid Pimenov, Elena Rechkova, Tatyana Rodionova, Oksana Rymar, Ruslan Sardinov, Olga Semenova, Alexander Sherenkov, Elena Smolyarchuk, Oleg Solovev, Leonid Strongin, Olga Ukhanova, Nadezhda Verlan, Natalya Vorokhobina, Davyd Yakhontov, Elena Zakharova, Alsu Zalevskaya, Olga Zanozina, Elena Zhdanova, Larisa Zhukova, Tatyana Zykova, Yong Mong Bee, Chee Fang Sum, Ru San Tan, Jana Babikova, Ingrid Buganova, Andrej Dzupina, Zuzana Ochodnicka, Dalibor Sosovec, Denisa Spodniakova, Fayzal Ahmed, Aslam Amod, Sindeep Bhana, Larry Distiller, Dirkie Jansen van Rensburg, Mukesh Joshi, Shaifali Joshi, Deepak Lakha, Essack Mitha, Gracjan Podgorski, Naresh Ranjith, Brian Rayner, Paul Rheeder, Mohamed Sarvan, Mary Seeber, Heidi Siebert, Mohammed Tayob, Julien Trokis, Dorothea Urbach, Louis van Zyl, Young Min Cho, ChoonHee Chung, YouCheol Hwang, JunGoo Kang, HyeSoon Kim, SinGon Kim, InJoo Kim, JaeHyeon Kim, WooJe Lee, ByungWan Lee, Soo Lim, Cheol Young Park, Jae Myung Yu, Hanane Bouarich, Francesca Calero, Cristina Castro, Fernando Cereto Castro, Secundino Cigarran Guldris, Josep Cruzado Garrit, Fernando de Alvaro, Josep Galceran, Olga Gonzalez Albarran, Julio Hernandez Jaras, Meritxell Ibernon, Francisco Martinez Deben, M. Dolores Martinez Esteban, Judith Martins, Juan Mediavilla, Alfredo Michan, Jose Maria Pascual Izuel, Julio Pascual Santos, Esteban Poch, Manuel Polaina Rusillo, Josep Redon, Carlos Sanchez Juan, Rafael Santamaria Olmo, Jose Julian Segura de la Morena, Daniel Seron, Alfonso Soto, Maribel Troya, Annette Bruchfeld, Dan Curiac, Ken Eliasson, Malin Frank, Gregor Guron, Olof Hellberg, Margareta Hellgren, Hans Larnefeldt, Carl-Johan Lindholm, Magnus Londahl, Erik Rein-Hedin, Inga Soveri, Jonas Spaak, Bengt-Olov Tengmark, Stefan Bilz, Marc Donath, Markus Laimer, Antoinette Pechere-Bertschi, Gottfried Rudofsky, Christopher Strey, Gregoire Wuerzner, Chiz-Tzung Chang, Cheng-Chieh Hung, Ju-Ying Jiang, Chien-Te Lee, Der-Cherng Tarng, Shih-Te Tu, Mai-Szu Wu, Ming-Ju Wu, Chaicharn Deerochanawong, Natapong Kosachunhanan, Chatlert Pongchaiyakul, Bancha Satirapoj, Piyamitr Sritara, Ozer Badak, Murat Cayli, Necmi Eren, Ibrahim Gul, Ismail Kocyigit, Abdulbaki Kumbasar, Ayetin Oguz, Oner Ozdogan, Idris Sahin, Ramazan Sari, Talat Tavli, Ahmet Temizhan, Mustafa Tigen, Sedat Ustundag, Yavuz Yenicerioglu, Iryna Bondarets, Volodymyr Botsyurko, Viktoriia Chernikova, Oleksandra Donets, Ivan Fushtey, Mariia Grachova, Anna Isayeva, Dmytro Kogut, Julia Komisarenko, Nonna Kravchun, Kateryna Malyar, Borys Mankovsky, Liliya Martynyuk, Vitaliy Maslyanko, Halyna Myshanych, Larysa Pererva, Nataliia Pertseva, Oleksandr Serhiyenko, Ivan Smirnov, Liubov Sokolova, Vasyl Stryzhak, Maryna Vlasenko, Imrozia Arif, Cuong Dang, Fahmy Hanna, Hassan Kahal, Dhanya Kalathil, Anne Kilvert, Sui Phi Kon, Christina Kyriakidou, Kieran McCafferty, Sam Rice, Pauline Swift, Arutchelvam Vijayaraman, Yuk-ki Wong, Idalia Acosta, Atoya Adams, Sharon Adler, Dilawar Ajani, Radica Alicic, Amer Al-Karadsheh, Sreedhara Alla, D. 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Sue Kirkman, Stanley Koch, Nelson Kopyt, Gary Korff, Wayne Kotzker, Csaba Kovesdy, Camil Kreit, Arvind Krishna, Saeed Kronfli, Keung Lee, Derek LeJeune, Brenda Lemus, Sam Lerman, Douglas Linfert, Henry Lora, Alexander Lurie, Geetha Maddukuri, Alexander Magno, Louis Maletz, Sreedhar Mandayam, Mustafa Mandviwala, Mariana Markell, Earl Martin, Ronald Mayfield, Caroline Mbogua, Dierdre McMullen, Carl Meisner, Jill Meyer, Stephen Minton, Bharat Mocherla, Manuel Montero, Moustafa Moustafa, Salil Nadkarni, Samer Nakhle, Jesus Navarro, Nilda Neyra, Romanita Nica, Philip Nicol, Paul Norwood, Visal Numrungroad, Richard O’Donovan, A. Odugbesan, David Oliver, Suzanne Oparil, Jorge Paoli-Bruno, Samir Parikh, Rajesh Patel, Rakesh Patel, Aldo Peixoto, Pablo Pergola, Karlton Pettis, Roberto Pisoni, Mirela Ponduchi, Larry Popeil, Jorge Posada, Sharma Prabhakar, Rupesh Raina, Kodangudi Ramanathan, Luis Ramon-Gonez, Anjay Rastogi, Efrain Reisin, Marc Rendell, Michael Rocco, Hugo Romeu, Sylvia Rosas, Dennis Ross, Jeffrey Rothman, Lance Rudolph, Yusuf Ruhullah, Gary Ruoff, Jeffrey Ryu, Mandeep Sahani, Garfield Samuels, William Sanchez, Sanjeev Saxena, David Scott, Gilberto Seco, Harvey Serota, Tariq Shafi, Nauman Shahid, Michael Shanik, Santosh Sharma, Arjun Sinha, James Smelser, Mark Smith, Kyaw Soe, Richard Solomon, Eugene Soroka, Joseph Soufer, Rosa Suarez, Bala Subramanian, Harold Szerlip, Aparna Tamirisa, Stephen Thomson, Tuan-Huy Tran, Richard Treger, Gretel Trullenque, Thomas Turk, Guillermo Umpierrez, Daniel Urbach, Martin Valdes, Shujauddin Valika, Damaris Vega, Peter Weissman, Adam Whaley-Connell, Jonathan Winston, Jonathan Wise, Michael Yuryev, Steven Zeig, Lam Van Hoang Lam Van Hoang, Tran Khanh Tran Khanh, Boi Ngoc Nguyen Boi Ngoc Nguyen, Nguyen Minh Nui Nguyen Minh Nui, Pham Nguyen Son Pham Nguyen Son, and Lan Phuong Tran Lan Phuong Tran. 2019. “Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial.” AMERICAN JOURNAL OF NEPHROLOGY 50 (5): 345–356.
Vancouver
1.
Ruilope LM, Agarwal R, Anker SD, Bakris GL, Filippatos G, Nowack C, et al. Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial. AMERICAN JOURNAL OF NEPHROLOGY. 2019;50(5):345–56.
IEEE
[1]
L. M. Ruilope et al., “Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial,” AMERICAN JOURNAL OF NEPHROLOGY, vol. 50, no. 5, pp. 345–356, 2019.
@article{8640533,
  abstract     = {Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.},
  author       = {Ruilope, Luis M. and Agarwal, Rajiv and Anker, Stefan D. and Bakris, George L. and Filippatos, Gerasimos and Nowack, Christina and Kolkhof, Peter and Joseph, Amer and Mentenich, Nicole and Pitt, Bertram and Aizenberg, Diego and Bartolacci, Ines and Besada, Diego and Bittar, Julio and Chahin, Mariano and Elbert, Alicia and Gelersztein, Elizabeth and Liberman, Alberto and Maffei, Laura and Perez Manghi, Federico and Sanabria, Hugo and Vallejos, Augusto and Vines, Gloria and Wassermann, Alfredo and Abhayaratna, Walter and Colman, Peter and Colquhon, David and Ekinci, Elif and MacIsaac, Richard and Mah, Peak Mann and Nelson, Craig and Packham, David and Pape, Alexia and Roger, Simon and Stephenson, Hugo and Suranyi, Michael and Topliss, Duncan and Vandeleur, James and Wittert, Gary and Wynne, Katie-Jane and Clodi, Martin and Drexel, Heinz and Ebenbichler, Christoph and Fliesser-Goerzer, Evelyn and Hanusch, Ursula and Ludvik, Bernhard and Neudorfer, Peter and Paulweber, Bernhard and Prager, Rudolf and Preiss, Wolfgang and Prischl, Friedrich and Schernthaner, Gerit-Holger and Schoenherr, Hans-Robert and Sourij, Harald and Doubel, Peter and Duyck, Francis and Engelen, Wendy and Gillard, Pieter and Hougardy, Jean-Michel and Scheen, Andre and Speeckaert, Marijn and Stas, Koen and van Gaal, Luc and Vanbelleghem, Hilde and Antunes, Daniela and Botelho, Roberto and Brito, Claudia and Canani, Luis and Canziani, Maria Eugenia and Cerqueira, Maria and de Paula, Rogerio and Eliaschewitz, Freddy and Figueiredo, Carlos Eduardo and Forti, Adriana and Hissa, Miguel and Leite, Maurilo, Jr. and Noronha, Irene and Paolino, Bruno and Paschoalin, Nathalia and Paschoalin, Raphael and Pecoits Filho, Roberto and Pereira, Marcio and Portes, Evandro and Precoma, Dalton and Rea, Rosangela and Riella, Miguel and Salles, Joao Eduardo and Vasconcellos, Eduardo and Vencio, Sergio and Boshnyashka, Radostina and Farah, Ghassan and Georgiev, Dimitar and Gushterova, Valentina and Klyuchkova, Neli and Lucheva, Mariya and Manova, Petya and Minkova, Dotska and Nonchev, Boyan and Pichmanova, Mariyana and Prakova, Zhulieta and Rangelov, Rangel and Rashkov, Rosen and Stanchev, Pavel and Stoyanovska-Elencheva, Bilyana and Tagarev, Zhivko and Temelkova-Kurktschieva, Theodora and Vasileva, Svetla and Yoncheva-Mihaylova, Mariana and Barre, Paul and Carlson, Brian and Conway, James and Cournoyer, Serge and Dumas, Richard and Fikry, Sameh and Goluch, Richard and Hamet, Pavel and Hart, Randolph and Henein, Sam and Kelly, Allan and Liutkus, Joanne and Madore, Francois and Martinho, Valdemar and Mazza, Giuseppe and McFarlane, Philip and O'Keefe, Dennis and Peterson, Sean and Schwartz, Daniel and Shu, Daniel and Steele, Andrew and Teitelbaum, Ivor and Tellier, Guy and Tennankore, Karthik and Tobe, Sheldon and Tsoukas, George and Tytus, Richard and Vitou, Louise and Walsh, Michael and Weisnagel, Stanley and Wilderman, Igor and Yale, Jean-Francois and Cobos, Jorge and Godoy, Juan and Gonzalez, Fernando and Medina, Marcelo and Carlos Palma, Juan and Carlos Prieto, Juan and Reyes, Eliana and Romero, Carmen and Saavedra, Victor and Varleta, Paola and Bu, Ruifang and Cai, Hanqing and Chen, Nan and Chen, Qinkai and Chen, Dejun and Cheng, Jinluo and Dong, Youping and Dong, Junwu and Du, Yuming and Fang, Yi and Guan, Tianjun and Guo, Weiying and Hao, Chuanming and Jiang, Fangfang and Jian, Sheng and Kuang, Jian and Lei, Minxiang and Li, Ling and Li, Dongmei and Li, Hongmei and Li, Jingmei and Li, Yan and Li, Yuxiu and Li, Zhonghe and Liu, Fang and Liu, Juan and Liu, Yinghong and Liu, Yuantao and Liu, Zhihong and Long, Gang and Lu, Guoyuan and Lu, Weiping and Lu, Yibing and Ma, Jianhua and Mo, Zhaohui and Niu, Jianying and Peng, Ai and Shen, Jiansong and Shen, Feixia and Shi, Bingyin and Su, Qing and Sun, Zhuxing and Tang, Shuifu and Tong, Nanwei and Wang, Hao and Wang, Xinjun and Wang, Lihua and Wang, Jianqin and Wang, Li and Wei, Jiali and Wu, Chaoqing and Wu, Tianfeng and Xing, Changying and Xiong, Fei and Xu, Xudong and Xu, Ning and Yang, Jinkui and Yin, Aiping and Zeng, Longyi and Zhang, Hao and Zhang, Yanlin and Zhang, Ying and Zhao, Zhiquan and Zheng, Hongguang and Zhong, Ling and Zhong, Liyong and Zhu, Dalong and Arango, Clara and Arcos, Edgar and Arcos, Gustavo and Barrera, Sandra and Barreto, German and Beltran Lopez, Nelly and Benitez, Diego and Blanco, Guillermo and Botero, Rodrigo and Cardenas, Tatiana and Coronel, Julian and Cure, Carlos and Duran, Carlos and Garcia, Luis and Guzman, Gustavo and Hernandez, Eric and Ibarra, Jaime and Jaramillo, Carlos and Jaramillo, Nicolas and Kattah, William and Molina, Dora and Sanchez, Gregorio and Terront, Monica and Trujillo, Freddy and Urina, Miguel and Villegas, Ivan and Yupanqui, Hernan and Alferi, Dino and Brada, Michal and Brezina, Jiri and Bucek, Petr and Edelsberger, Tomas and Gulakova, Drahomira and Zapletalova, Jitka Hasalova and Hola, Olga and Hornova, Lucie and Houdova, Jana and Hrmova, Helena and Karasek, David and Kopecka, Sarka and Kovar, Richard and Krcova, Eva and Kuchar, Jiri and Kutejova, Vlasta and Lubanda, Hana and Matyasek, Ivo and Mokrejsova, Magdalena and Okenka, Libor and Prazny, Martin and Pumprla, Jiri and Tomanek, Pavel and Bech, Jesper and Faber, Jens and Gislason, Gunnar and Hangaard, Jorgen and Pacyk, Grzegorz Jaroslaw and Juhl, Claus and Krarup, Thure and Lindhardt, Morten and Madsbad, Sten and Nielsen, Joan and Pedersen-Bjergaard, Ulrik and Poulsen, Per and Rasmussen, Ole and Rossing, Peter and Schousboe, Karoline and Honkasalo, Mikko and Humaloja, Kari and Kananen, Kristiina and Kantola, Ilkka and Koistinen, Arvo and Korsoff, Pirkko and Lahtela, Jorma and Nieminen, Sakari and Nieminen, Tuomo and Sadeharju, Karita and Strand, Jorma and Sulosaari, Sakari and Cariou, Bertrand and Chantrel, FranOois and Clavel, Sylvaine and Fauvel, Jean-Pierre and Gallouj, Karim and Gouet, Didier and Guerci, Bruno and Guerrot, Dominique and Klein, Alexandre and Le Meur, Yannick and Mesbah, Rafik and Monier, Arnaud and Moranne, Olivier and Roussel, Ronan and Serusclat, Pierre and Verges, Bruno and Zaoui, Philippe and Axthelm, Christoph and Birkenfeld, Andreas and Braun, Hermann and Busch, Klaus and Contzen, Christel and Degenhardt, Stefan and Derwahl, Karl and Giebel, Thomas and Hagenow, Andreas and Haller, Hermann and Hasslacher, Christoph and Horacek, Thomas and Jungmair, Wolfgang and Kloos, Christof and Koch, Thorsten and Krueger, Thilo and Mueller, Joachim and Nischik, Ruth and Pfuetzner, Andreas and Pistrosch, Frank and Rose, Ludger and Rump, Lars and Schettler, Volker and Schiefke, Ingolf and Schlichthaar, Heike and Schroeppel, Bernd and Schuerholz, Thomas and Sigal, Helena and Stemler, Lutz and Strack, Georg and Taeschner, Heidrun and Toursarkissian, Nicole and Tschoepe, Diethelm and Ulmer, Achim and van der Giet, Markus and Wanner, Christoph and Winkelmann, Bernhard R. and Boletis, Ioannis and Hatziagelaki, Erifili and Ioannidis, Ioannis and Kounadi, Theodora and Makriniotou, Ioanna and Papadopoulou, Dorothea and Papagianni, Aikaterini and Passadakis, Ploumis and Stefanidis, Ioannis and Ip, Tai Pang and Lee, Paul and Ma, Ching Wan Ronald and Yeung, Vincent and Bajcsi, Dora and Danos, Peter and Harcsa, Eleonora and Kalina, Akos and Kazup, Szilvia and Keltai, Katalin and Kirschner, Robert and Kiss, Julianna and Kovacs, Laszlo and Lamboy, Beata and Literati-Nagy, Botond and Mileder, Margit and Nagy, Laszlo and Noori, Ebrahim and Nyirati, Gabor and Petro, Gizella and Schneider, Karoly and Szocs, Albert and Vasas, Szilard and Wudi, Krisztina and Zilahi, Zsolt and Zsom, Marianna and Eustace, Joe and Hatunic, Mensud and Holian, John and Reddan, Donal and O'Meara, Yvonne and Ness, Rosane Abramof and Adawi, Faiad and Armaly, Zaher and Atar, Shaul and Bashkin, Amir and Ben Chetrit, Sydney and Yanay, Noa Berar and Chernin, Gil and Darawsha, Mahmud and Efrati, Shai and Elias, Mazen and Farber, Evgeny and Glandt, Mariela and Grossman, Ehud and Halabi, Majdi and Liberty, Idit and Mosenzon, Ofri and Nimer, Assy and Schwartz, Doron and Wainstein, Julio and Yagil, Yoram and Zukermann, Robert and Battaglia, Giovanni Giorgio and Bonora, Enzo and Bossi, Carlo Antonio and Calabro, Paolo and Cavalot, Franco Luigi and Cimino, Roberto and Emdin, Michele and Fiaccadori, Enrico and Fiorina, Paolo and Giorda, Carlo Bruno and Gregorini, Maria Cristina and La Manna, Gaetano and Maggi, Davide Carlo and Pani, Antonello and Perico, Norberto and Piatti, PierMarco and Pisani, Antonio and Ponzani, Paola and Santorelli, Gennaro and Santoro, Domenico and Tonolo, Giancarlo and Trevisan, Roberto and Veronelli, Anna Maria and Araki, Hideo and Ebisui, Osamu and Fujita, Naruhiro and Furuya, Ryuichi and Hamamoto, Yoshiyuki and Hatazaki, Masahiro and Hayashi, Terumasa and Higashi, Takayuki and Hirohata, Yoshihide and Horinouchi, Shuji and Imoto, Hirofumi and Inagaki, Akemi and Inagaki, Masayuki and Ishii, Masao and Ishiko, Tamayo and Jinnouchi, Hideaki and Kanai, Hidetoshi and Kanda, Daisuke and Kanehara, Hideo and Kashima, Masayuki and Kato, Kiyoe and Katsuki, Takeshi and Kawamitsu, Katsunori and Kawasaki, Satsuki and Kikuchi, Fumi and Kikuchi, Hidetoshi and Kobayashi, Kunihisa and Koide, Junko and Kubota, Miyuki and Kusano, Yoshiro and Maeda, Hajime and Matsubayashi, Sunao and Matsumoto, Kazunari and Matsuo, Yasuto and Matsuoka, Naoki and Miyaoka, Hiroaki and Murao, Satoshi and Nakayama, Mikihiro and Nakazawa, Jun and Nomiyama, Takashi and Noritake, Masayuki and Ogiwara, Takayuki and Ohashi, Hiroshi and Okamoto, Hideki and Osonoi, Takeshi and Sasaki, Nobuhiro and Sekigami, Taiji and Shibasaki, Taro and Shibata, Hirotaka and Shinoda, Junji and Sobajima, Hiroshi and Sugitatsu, Kazuya and Sugiura, Toshiyuki and Sugiyama, Toru and Suzuki, Daisuke and Suzuki, Masaaki and Tanaka, Asami and Tanaka, Seiichi and Tsunematsu, Izumi and Ujihara, Makoto and Yamada, Daishiro and Yamada, Masayo and Yamagata, Kazuo and Yamakawa, Fumiko and Yamakawa, Ken and Yamasaki, Yoshimitsu and Yambe, Yuko and Yanai, Hidekatsu and Yasuda, Tetsuyuki and Kriauciuniene, Dovile and Lasiene, Jurate and Navickas, Antanas and Radzeviciene, Lina and Urbanaviciene, Egle and Urbonas, Gediminas and Velaviciene, Audrone and Aziz, Nor Azizah and Lee, Li Yuan and Loh, Chek Loong and Mohamad, Masni and Ali, Norhaliza Mohd and Khir, Rizmy Najme and Ahmad, Nik Nur Fatnoon Nik and Ratnasingam, Jeyakantha and Hasan, Wan Hasnul Halimi Bin Wan and Mohamed, Wan Mohd Izani Wan and Alpizar Salazar, Melchor and Avila Pardo, Sandro and Bastidas Adrian, Miriam and Chew Wong, Alfredo and Escobedo de la Pe a, Jorge and Fanghanel Salmon, Guillermo and Garc-a Hernandez, Pedro and Gonzalez Galvez, Guillermo and Gonzalez Gonzalez, Jose and Gutierrez Ochoa, Ramiro and Irizar Santana, Saul and Lazcano Soto, Jose and Madero Rovalo, Magdalena and Mendez Machado, Gustavo and Nevarez Ruiz, Luis and Ramos Lopez, Gabriel and Saldana Mendoza, Arturo and Sauque Reyna, Leobardo and Solache Ortiz, Gustavo and Valdez Ortiz, Rafael and Villagordoa Mesa, Juan and Bakker, R. C. and Barendregt, J. N. M. and Boonstra, A. H. and Brouwer, C. B. and van Buren, M. and Gansevoort, Ron and Kooy, Adriaan and Krekels, Marielle and van Leendert, Ruud J. M. and Lieverse, Louis A. G. and Luik, P. T. and Penne, E. Lars and van den Born, Bert-Jan and Vogt, Liffert and Baker, John and Crawford, Veronica and Cutfield, Rick and Dunn, Peter and Krebs, Jeremy and Nirmalaraj, Kingsley and Scott, Russell and Smuts, Nine and Asprusten, Emil and Eriksen, Erik and Finnes, Trine and Hagemeier, Robert and Hoivik, Hans and Karlsson, Thomas and Risberg, Knut and Rocke, Jan and Selsas, Hilde and Solnor, Leidulv and Thorup, Frode and Bautista, Albert and Catindig, Elizabeth and Mirasol, Roberto and Pamugas, Glenda and Tanque, Maribel and Tirador, Louie and Butrymowicz, Patrycja and Ciechanowski, Kazimierz and Cieslik, Grazyna and Franek, Edward and Gumprecht, Janusz and Hoffmann, Michal and Krzykowska, Jolanta and Kurnatowska, Ilona and Landa, Katarzyna and Madrzejewski, Adam and Madziarska, Katarzyna and Mazur, Stanislaw and Napora, Piotr and Nowicki, Michal and Ocicka-Kozakiewicz, Anna and Rewerska, Barbara and Rusicka, Teresa and Ruxer, Jan and Skokowska, Ewa and Stankiewicz, Andrzej and Stompor, Tomasz and Tiuryn-Petrulewicz, Agnieszka and Wasilewska, Katarzyna and Wierusz-Wysocka, Bogna and Wnetrzak-Michalska, Renata and Almeida, Edgar and Ballesteros, Rosa and Barreto, Carlos and Brandao, Ilidio and Carvalho, Rui and Esteves, Cesar and Guia, Jose and Heitor, Susana and Matos, Pedro and Melo, Pedro and Nolasco, Fernando and Pereira, Amalia and Roque, Cristina and Rosario, Francisco and Silva, Gil and Silva, Ana and Teixeira e Costa, Fernando and Lobos, Ana Vila and Cortes-Maisonet, Gregorio and Roman-Miranda, Amaury and Albota, Adrian and Bala, Cornelia and Barbonta, Hortensia and Caceaune, Elena and Catrinoui, Doina and Constantin, Ciprian and Dumitrescu, Adriana and Mindrescu, Nicoleta and Mistode, Cristina and Negrisanu, Gabriela and Onaca, Adriana and Paveliu, Silvia and Pintilei, Ella and Pop, Lavinia and Popa, Amorin and Popescu, Alexandrina and Radulian, Gabriela and Szilagyi, Iosif and Turcu, Liana and Vacaru, Georgeta and Vlad, Adrian and Antsiferov, Mikhail and Arkhipov, Mikhail and Babkin, Andrey and Baranov, Vitaliy and Barbarash, Olga and Chernyavskaya, Elena and Demko, Arkadiy and Dreval, Alexander and Edin, Anton and Ermakova, Polina and Galyavich, Albert and Gaysina, Leyla and Gordeev, Ivan and Ipatko, Irina and Kalashnikova, Marina and Khalimov, Yuriy and Klimontov, Vadim and Kobalava, Zhanna and Kosmacheva, Elena and Koziolova, Natalya and Kvitkova, Lyudmila and Levashov, Sergey and Libis, Roman and Malykh, Natalia and Malyutina, Sofya and Marasaev, Vyacheslav and Mareev, Vyacheslav and Martynenko, Vladimir and Merai, Imad and Mkrtumyan, Ashot and Nechaeva, Galina and Nikolaev, Konstantin and Palyutin, Shamil and Petunina, Nina and Pimenov, Leonid and Rechkova, Elena and Rodionova, Tatyana and Rymar, Oksana and Sardinov, Ruslan and Semenova, Olga and Sherenkov, Alexander and Smolyarchuk, Elena and Solovev, Oleg and Strongin, Leonid and Ukhanova, Olga and Verlan, Nadezhda and Vorokhobina, Natalya and Yakhontov, Davyd and Zakharova, Elena and Zalevskaya, Alsu and Zanozina, Olga and Zhdanova, Elena and Zhukova, Larisa and Zykova, Tatyana and Bee, Yong Mong and Sum, Chee Fang and Tan, Ru San and Babikova, Jana and Buganova, Ingrid and Dzupina, Andrej and Ochodnicka, Zuzana and Sosovec, Dalibor and Spodniakova, Denisa and Ahmed, Fayzal and Amod, Aslam and Bhana, Sindeep and Distiller, Larry and van Rensburg, Dirkie Jansen and Joshi, Mukesh and Joshi, Shaifali and Lakha, Deepak and Mitha, Essack and Podgorski, Gracjan and Ranjith, Naresh and Rayner, Brian and Rheeder, Paul and Sarvan, Mohamed and Seeber, Mary and Siebert, Heidi and Tayob, Mohammed and Trokis, Julien and Urbach, Dorothea and van Zyl, Louis and Cho, Young Min and Chung, ChoonHee and Hwang, YouCheol and Kang, JunGoo and Kim, HyeSoon and Kim, SinGon and Kim, InJoo and Kim, JaeHyeon and Lee, WooJe and Lee, ByungWan and Lim, Soo and Park, Cheol Young and Yu, Jae Myung and Bouarich, Hanane and Calero, Francesca and Castro, Cristina and Cereto Castro, Fernando and Cigarran Guldris, Secundino and Garrit, Josep Cruzado and de Alvaro, Fernando and Galceran, Josep and Gonzalez Albarran, Olga and Hernandez Jaras, Julio and Ibernon, Meritxell and Martinez Deben, Francisco and Martinez Esteban, M. Dolores and Martins, Judith and Mediavilla, Juan and Michan, Alfredo and Pascual Izuel, Jose Maria and Pascual Santos, Julio and Poch, Esteban and Polaina Rusillo, Manuel and Redon, Josep and Sanchez Juan, Carlos and Santamaria Olmo, Rafael and Segura de la Morena, Jose Julian and Seron, Daniel and Soto, Alfonso and Troya, Maribel and Bruchfeld, Annette and Curiac, Dan and Eliasson, Ken and Frank, Malin and Guron, Gregor and Hellberg, Olof and Hellgren, Margareta and Larnefeldt, Hans and Lindholm, Carl-Johan and Londahl, Magnus and Rein-Hedin, Erik and Soveri, Inga and Spaak, Jonas and Tengmark, Bengt-Olov and Bilz, Stefan and Donath, Marc and Laimer, Markus and Pechere-Bertschi, Antoinette and Rudofsky, Gottfried and Strey, Christopher and Wuerzner, Gregoire and Chang, Chiz-Tzung and Hung, Cheng-Chieh and Jiang, Ju-Ying and Lee, Chien-Te and Tarng, Der-Cherng and Tu, Shih-Te and Wu, Mai-Szu and Wu, Ming-Ju and Deerochanawong, Chaicharn and Kosachunhanan, Natapong and Pongchaiyakul, Chatlert and Satirapoj, Bancha and Sritara, Piyamitr and Badak, Ozer and Cayli, Murat and Eren, Necmi and Gul, Ibrahim and Kocyigit, Ismail and Kumbasar, Abdulbaki and Oguz, Ayetin and Ozdogan, Oner and Sahin, Idris and Sari, Ramazan and Tavli, Talat and Temizhan, Ahmet and Tigen, Mustafa and Ustundag, Sedat and Yenicerioglu, Yavuz and Bondarets, Iryna and Botsyurko, Volodymyr and Chernikova, Viktoriia and Donets, Oleksandra and Fushtey, Ivan and Grachova, Mariia and Isayeva, Anna and Kogut, Dmytro and Komisarenko, Julia and Kravchun, Nonna and Malyar, Kateryna and Mankovsky, Borys and Martynyuk, Liliya and Maslyanko, Vitaliy and Myshanych, Halyna and Pererva, Larysa and Pertseva, Nataliia and Serhiyenko, Oleksandr and Smirnov, Ivan and Sokolova, Liubov and Stryzhak, Vasyl and Vlasenko, Maryna and Arif, Imrozia and Dang, Cuong and Hanna, Fahmy and Kahal, Hassan and Kalathil, Dhanya and Kilvert, Anne and Kon, Sui Phi and Kyriakidou, Christina and McCafferty, Kieran and Rice, Sam and Swift, Pauline and Vijayaraman, Arutchelvam and Wong, Yuk-ki and Acosta, Idalia and Adams, Atoya and Adler, Sharon and Ajani, Dilawar and Alicic, Radica and Al-Karadsheh, Amer and Alla, Sreedhara and Allison, D. and Andrawis, Nabil and Arif, Ahmed and Awad, Ahmed and Azizad, Masoud and Bahrami, Michael and Bansal, Shweta and Barag, Steven and Barakzoy, Ahmad and Barney, Mark and Bashir, Khalid and Bautista, Jose and Beddhu, Srinivasan and Benjamin, Sabrina and Berenji, Ramin and Bertsch, John and Bhargava, Anuj and Birriel, Jose and Bleich, David and Bornfreund, Jonathan and Brar, Harjeet and Brian, Susan and Brietzke, Stephen and Brusco, Osvaldo and Burgner, Anna and Busch, Robert and Canadas, Rafael and Caramori, Maria and Cardona, Jose and Carpio, Jose and Case, Christopher and Cruz, Humberto and Dandillaya, Ramprasad and Dhanireddy, Soni and Din, Zia and Dixon, Bradley and Doshi, Ankur and El Shahawy, Mahfouz and El-Shahawy, Mohammed and Evans, John and Fadda, George and Farooq, Umar and Fernando, Roland and Fink, Raymond and First, Brian and Fitz-Patrick, David and Flack, John and Fluck, Patrick and Fogelfeld, Leon and Fonseca, Vivian and Frias, Juan and Galphin, Claude and Garcia-Mayol, Luis and Goldstein, Gary and Gonzalez, Edgar and Gonzalez-Abreu, Francisco and Gore, Ashwini and Grant, David and Habwe, Violet and Halpern, Stephen and Hamilton, Maxine and Hammoud, Jamal and Handelsman, Stuart and Hartman, Israel and Heigerick, Glenn and Hernandez, German and Hernandez-Cassis, Carlos and Herrera, Carlos and Iranmanesh, Ali and Jackson, Timothy and Jain, Mahendra and Jamerson, Kenneth and Johnson, Karen and Kayali, Zeid and Kaye, William and Khan, Bobby and Khan, Muhammad and Kharait, Sourabh and Kirkman, M. Sue and Koch, Stanley and Kopyt, Nelson and Korff, Gary and Kotzker, Wayne and Kovesdy, Csaba and Kreit, Camil and Krishna, Arvind and Kronfli, Saeed and Lee, Keung and LeJeune, Derek and Lemus, Brenda and Lerman, Sam and Linfert, Douglas and Lora, Henry and Lurie, Alexander and Maddukuri, Geetha and Magno, Alexander and Maletz, Louis and Mandayam, Sreedhar and Mandviwala, Mustafa and Markell, Mariana and Martin, Earl and Mayfield, Ronald and Mbogua, Caroline and McMullen, Dierdre and Meisner, Carl and Meyer, Jill and Minton, Stephen and Mocherla, Bharat and Montero, Manuel and Moustafa, Moustafa and Nadkarni, Salil and Nakhle, Samer and Navarro, Jesus and Neyra, Nilda and Nica, Romanita and Nicol, Philip and Norwood, Paul and Numrungroad, Visal and O'Donovan, Richard and Odugbesan, A. and Oliver, David and Oparil, Suzanne and Paoli-Bruno, Jorge and Parikh, Samir and Patel, Rajesh and Patel, Rakesh and Peixoto, Aldo and Pergola, Pablo and Pettis, Karlton and Pisoni, Roberto and Ponduchi, Mirela and Popeil, Larry and Posada, Jorge and Prabhakar, Sharma and Raina, Rupesh and Ramanathan, Kodangudi and Ramon-Gonez, Luis and Rastogi, Anjay and Reisin, Efrain and Rendell, Marc and Rocco, Michael and Romeu, Hugo and Rosas, Sylvia and Ross, Dennis and Rothman, Jeffrey and Rudolph, Lance and Ruhullah, Yusuf and Ruoff, Gary and Ryu, Jeffrey and Sahani, Mandeep and Samuels, Garfield and Sanchez, William and Saxena, Sanjeev and Scott, David and Seco, Gilberto and Serota, Harvey and Shafi, Tariq and Shahid, Nauman and Shanik, Michael and Sharma, Santosh and Sinha, Arjun and Smelser, James and Smith, Mark and Soe, Kyaw and Solomon, Richard and Soroka, Eugene and Soufer, Joseph and Suarez, Rosa and Subramanian, Bala and Szerlip, Harold and Tamirisa, Aparna and Thomson, Stephen and Tran, Tuan-Huy and Treger, Richard and Trullenque, Gretel and Turk, Thomas and Umpierrez, Guillermo and Urbach, Daniel and Valdes, Martin and Valika, Shujauddin and Vega, Damaris and Weissman, Peter and Whaley-Connell, Adam and Winston, Jonathan and Wise, Jonathan and Yuryev, Michael and Zeig, Steven and Lam Van Hoang, Lam Van Hoang and Tran Khanh, Tran Khanh and Boi Ngoc Nguyen, Boi Ngoc Nguyen and Nguyen Minh Nui, Nguyen Minh Nui and Pham Nguyen Son, Pham Nguyen Son and Lan Phuong Tran, Lan Phuong Tran},
  issn         = {0250-8095},
  journal      = {AMERICAN JOURNAL OF NEPHROLOGY},
  keywords     = {WORSENING RENAL-FUNCTION,CHRONIC HEART-FAILURE,MINERALOCORTICOID,RECEPTOR,BAY 94-8862,SPIRONOLACTONE,ANTAGONIST,RISK,EFFICACY,MILD,COMPLICATIONS,Kidney,Mineralocorticoid,Diabetes,Aldosterone,Outcomes,Clinical},
  language     = {eng},
  number       = {5},
  pages        = {345--356},
  title        = {Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial},
  url          = {http://dx.doi.org/10.1159/000503712},
  volume       = {50},
  year         = {2019},
}

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