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Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases

(2020) GASTROENTEROLOGY. 158(1). p.95-110
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Abstract
Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions. For example, specific glycans regulate T-cell activation, structures, and functions of immunoglobulins; interactions between microbes and immune and epithelial cells; and malignant transformation in the intestine and liver. We review the effects of protein glycosylation in regulation of gastrointestinal and liver functions, and how alterations in glycosylation serve as diagnostic or prognostic factors, or as targets for therapy.
Keywords
N-ACETYLGLUCOSAMINYLTRANSFERASE-III, CHRONIC HEPATITIS-C, EARLY, HEPATOCELLULAR-CARCINOMA, MUCOSA-ASSOCIATED MICROBIOTA, BOWEL-DISEASE, NONALCOHOLIC STEATOHEPATITIS, GLYCAN INTERACTIONS, IMMUNOGLOBULIN-G, CROHNS-DISEASE, FUCOSYLATED GLYCOPROTEINS, Glycan, Glycome, Glycomic, Glycosylation, IBD, Liver Disease

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Citation

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MLA
Verhelst, Xavier, et al. “Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases.” GASTROENTEROLOGY, vol. 158, no. 1, 2020, pp. 95–110.
APA
Verhelst, X., Dias, A. M., Colombel, J.-F., Vermeire, S., Van Vlierberghe, H., Callewaert, N., & Pinho, S. S. (2020). Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases. GASTROENTEROLOGY, 158(1), 95–110.
Chicago author-date
Verhelst, Xavier, Ana M Dias, Jean-Frederic Colombel, Severine Vermeire, Hans Van Vlierberghe, Nico Callewaert, and Salome S Pinho. 2020. “Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases.” GASTROENTEROLOGY 158 (1): 95–110.
Chicago author-date (all authors)
Verhelst, Xavier, Ana M Dias, Jean-Frederic Colombel, Severine Vermeire, Hans Van Vlierberghe, Nico Callewaert, and Salome S Pinho. 2020. “Protein Glycosylation as a Diagnostic and Prognostic Marker of Chronic Inflammatory Gastrointestinal and Liver Diseases.” GASTROENTEROLOGY 158 (1): 95–110.
Vancouver
1.
Verhelst X, Dias AM, Colombel J-F, Vermeire S, Van Vlierberghe H, Callewaert N, et al. Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases. GASTROENTEROLOGY. 2020;158(1):95–110.
IEEE
[1]
X. Verhelst et al., “Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases,” GASTROENTEROLOGY, vol. 158, no. 1, pp. 95–110, 2020.
@article{8640184,
  abstract     = {Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions. For example, specific glycans regulate T-cell activation, structures, and functions of immunoglobulins; interactions between microbes and immune and epithelial cells; and malignant transformation in the intestine and liver. We review the effects of protein glycosylation in regulation of gastrointestinal and liver functions, and how alterations in glycosylation serve as diagnostic or prognostic factors, or as targets for therapy.},
  author       = {Verhelst, Xavier and Dias, Ana M and Colombel, Jean-Frederic and Vermeire, Severine and Van Vlierberghe, Hans and Callewaert, Nico and Pinho, Salome S},
  issn         = {0016-5085},
  journal      = {GASTROENTEROLOGY},
  keywords     = {N-ACETYLGLUCOSAMINYLTRANSFERASE-III,CHRONIC HEPATITIS-C,EARLY,HEPATOCELLULAR-CARCINOMA,MUCOSA-ASSOCIATED MICROBIOTA,BOWEL-DISEASE,NONALCOHOLIC STEATOHEPATITIS,GLYCAN INTERACTIONS,IMMUNOGLOBULIN-G,CROHNS-DISEASE,FUCOSYLATED GLYCOPROTEINS,Glycan,Glycome,Glycomic,Glycosylation,IBD,Liver Disease},
  language     = {eng},
  number       = {1},
  pages        = {95--110},
  title        = {Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases},
  url          = {http://dx.doi.org/10.1053/j.gastro.2019.08.060},
  volume       = {158},
  year         = {2020},
}

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