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N-cadherin stabilises neural identity by dampening anti-neural signals

Karolina Punovuori, Rosa P Migueles, Mattias Malaguti, Guillaume Blin, Kenneth G Macleod, Neil O Carragher, Tim Pieters (UGent) , Frans Van Roy (UGent) , Marc P Stemmler and Sally Lowell
(2019) DEVELOPMENT. 146(21).
Author
Organization
Abstract
A switch from E- to N-cadherin regulates the transition from pluripotency to neural identity, but the mechanism by which cadherins regulate differentiation was previously unknown. Here, we show that the acquisition of N-cadherin stabilises neural identity by dampening anti-neural signals. We use quantitative image analysis to show that N-cadherin promotes neural differentiation independently of its effects on cell cohesiveness. We reveal that cadherin switching diminishes the level of nuclear beta-catenin, and that N-cadherin also dampens FGF activity and consequently stabilises neural fate. Finally, we compare the timing of cadherin switching and differentiation in vivo and in vitro, and find that this process becomes dysregulated during in vitro differentiation. We propose that N-cadherin helps to propagate a stable neural identity throughout the emerging neuroepithelium, and that dysregulation of this process contributes to asynchronous differentiation in culture.
Keywords
EMBRYONIC STEM-CELLS, INDUCIBLE CASSETTE EXCHANGE, GROWTH-FACTOR, RECEPTOR, BETA-CATENIN, STATE PLURIPOTENCY, NEURITE OUTGROWTH, WNT/BETA-CATENIN, GROUND-STATE, MOUSE, WNT, Cadherin, FGF, Neural development, Pluripotent, Wnt, Mouse

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MLA
Punovuori, Karolina, et al. “N-Cadherin Stabilises Neural Identity by Dampening Anti-Neural Signals.” DEVELOPMENT, vol. 146, no. 21, 2019, doi:10.1242/dev.183269.
APA
Punovuori, K., Migueles, R. P., Malaguti, M., Blin, G., Macleod, K. G., Carragher, N. O., … Lowell, S. (2019). N-cadherin stabilises neural identity by dampening anti-neural signals. DEVELOPMENT, 146(21). https://doi.org/10.1242/dev.183269
Chicago author-date
Punovuori, Karolina, Rosa P Migueles, Mattias Malaguti, Guillaume Blin, Kenneth G Macleod, Neil O Carragher, Tim Pieters, Frans Van Roy, Marc P Stemmler, and Sally Lowell. 2019. “N-Cadherin Stabilises Neural Identity by Dampening Anti-Neural Signals.” DEVELOPMENT 146 (21). https://doi.org/10.1242/dev.183269.
Chicago author-date (all authors)
Punovuori, Karolina, Rosa P Migueles, Mattias Malaguti, Guillaume Blin, Kenneth G Macleod, Neil O Carragher, Tim Pieters, Frans Van Roy, Marc P Stemmler, and Sally Lowell. 2019. “N-Cadherin Stabilises Neural Identity by Dampening Anti-Neural Signals.” DEVELOPMENT 146 (21). doi:10.1242/dev.183269.
Vancouver
1.
Punovuori K, Migueles RP, Malaguti M, Blin G, Macleod KG, Carragher NO, et al. N-cadherin stabilises neural identity by dampening anti-neural signals. DEVELOPMENT. 2019;146(21).
IEEE
[1]
K. Punovuori et al., “N-cadherin stabilises neural identity by dampening anti-neural signals,” DEVELOPMENT, vol. 146, no. 21, 2019.
@article{8639707,
  abstract     = {{A switch from E- to N-cadherin regulates the transition from pluripotency to neural identity, but the mechanism by which cadherins regulate differentiation was previously unknown. Here, we show that the acquisition of N-cadherin stabilises neural identity by dampening anti-neural signals. We use quantitative image analysis to show that N-cadherin promotes neural differentiation independently of its effects on cell cohesiveness. We reveal that cadherin switching diminishes the level of nuclear beta-catenin, and that N-cadherin also dampens FGF activity and consequently stabilises neural fate. Finally, we compare the timing of cadherin switching and differentiation in vivo and in vitro, and find that this process becomes dysregulated during in vitro differentiation. We propose that N-cadherin helps to propagate a stable neural identity throughout the emerging neuroepithelium, and that dysregulation of this process contributes to asynchronous differentiation in culture.}},
  articleno    = {{dev183269}},
  author       = {{Punovuori, Karolina and Migueles, Rosa P and Malaguti, Mattias and Blin, Guillaume and Macleod, Kenneth G and Carragher, Neil O and Pieters, Tim and Van Roy, Frans and Stemmler, Marc P and Lowell, Sally}},
  issn         = {{0950-1991}},
  journal      = {{DEVELOPMENT}},
  keywords     = {{EMBRYONIC STEM-CELLS,INDUCIBLE CASSETTE EXCHANGE,GROWTH-FACTOR,RECEPTOR,BETA-CATENIN,STATE PLURIPOTENCY,NEURITE OUTGROWTH,WNT/BETA-CATENIN,GROUND-STATE,MOUSE,WNT,Cadherin,FGF,Neural development,Pluripotent,Wnt,Mouse}},
  language     = {{eng}},
  number       = {{21}},
  pages        = {{13}},
  title        = {{N-cadherin stabilises neural identity by dampening anti-neural signals}},
  url          = {{http://doi.org/10.1242/dev.183269}},
  volume       = {{146}},
  year         = {{2019}},
}
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