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Interferons : a molecular switch between damage and repair in ageing and Alzheimer's disease

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Abstract
Alzheimer's disease was first described over 100 years ago, yet it remains incurable and affects 44 million people worldwide. Traditionally, research has largely focused on the amyloid cascade hypothesis, but interest in the importance of inflammation in the progression of the disease has recently been increasing. Interferons, a large family of cytokines that trigger the immune system, are believed to play a crucial role in the pathology of Alzheimer's disease. This review focuses on how interferons affect the brain during ageing and whether they could be candidate therapeutic targets for the treatment of Alzheimer's disease.
Keywords
CENTRAL-NERVOUS-SYSTEM, REGULATORY T-CELLS, EXPERIMENTAL ALLERGIC, ENCEPHALOMYELITIS, NITRIC-OXIDE PRODUCTION, GAMMA GENE-EXPRESSION, BETA-AMYLOID PROTEIN, BLOOD-BRAIN-BARRIER, CHOROID-PLEXUS, IFN-GAMMA, MOUSE MODEL, Interferons, Type I IFN, Type II IFN, Alzheimer's disease, Choroid, plexus, Inflammation

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Citation

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MLA
Gorlé, Nina, and Roosmarijn Vandenbroucke. “Interferons : A Molecular Switch between Damage and Repair in Ageing and Alzheimer’s Disease.” MECHANISMS OF AGEING AND DEVELOPMENT, vol. 183, 2019.
APA
Gorlé, N., & Vandenbroucke, R. (2019). Interferons : a molecular switch between damage and repair in ageing and Alzheimer’s disease. MECHANISMS OF AGEING AND DEVELOPMENT, 183.
Chicago author-date
Gorlé, Nina, and Roosmarijn Vandenbroucke. 2019. “Interferons : A Molecular Switch between Damage and Repair in Ageing and Alzheimer’s Disease.” MECHANISMS OF AGEING AND DEVELOPMENT 183.
Chicago author-date (all authors)
Gorlé, Nina, and Roosmarijn Vandenbroucke. 2019. “Interferons : A Molecular Switch between Damage and Repair in Ageing and Alzheimer’s Disease.” MECHANISMS OF AGEING AND DEVELOPMENT 183.
Vancouver
1.
Gorlé N, Vandenbroucke R. Interferons : a molecular switch between damage and repair in ageing and Alzheimer’s disease. MECHANISMS OF AGEING AND DEVELOPMENT. 2019;183.
IEEE
[1]
N. Gorlé and R. Vandenbroucke, “Interferons : a molecular switch between damage and repair in ageing and Alzheimer’s disease,” MECHANISMS OF AGEING AND DEVELOPMENT, vol. 183, 2019.
@article{8639689,
  abstract     = {Alzheimer's disease was first described over 100 years ago, yet it remains incurable and affects 44 million people worldwide. Traditionally, research has largely focused on the amyloid cascade hypothesis, but interest in the importance of inflammation in the progression of the disease has recently been increasing. Interferons, a large family of cytokines that trigger the immune system, are believed to play a crucial role in the pathology of Alzheimer's disease. This review focuses on how interferons affect the brain during ageing and whether they could be candidate therapeutic targets for the treatment of Alzheimer's disease.},
  articleno    = {111148},
  author       = {Gorlé, Nina and Vandenbroucke, Roosmarijn},
  issn         = {0047-6374},
  journal      = {MECHANISMS OF AGEING AND DEVELOPMENT},
  keywords     = {CENTRAL-NERVOUS-SYSTEM,REGULATORY T-CELLS,EXPERIMENTAL ALLERGIC,ENCEPHALOMYELITIS,NITRIC-OXIDE PRODUCTION,GAMMA GENE-EXPRESSION,BETA-AMYLOID PROTEIN,BLOOD-BRAIN-BARRIER,CHOROID-PLEXUS,IFN-GAMMA,MOUSE MODEL,Interferons,Type I IFN,Type II IFN,Alzheimer's disease,Choroid,plexus,Inflammation},
  language     = {eng},
  pages        = {9},
  title        = {Interferons : a molecular switch between damage and repair in ageing and Alzheimer's disease},
  url          = {http://dx.doi.org/10.1016/j.mad.2019.111148},
  volume       = {183},
  year         = {2019},
}

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