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MALT1-deficient mice develop atopic-like dermatitis upon aging

Annelies Demeyer (UGent) , Elien Van Nuffel (UGent) , Griet Baudelet (UGent) , Yasmine Driege (UGent) , Marja Kreike (UGent) , David Muyllaert (UGent) , Jens Staal (UGent) and Rudi Beyaert (UGent)
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Abstract
MALT1 plays an important role in innate and adaptive immune signaling by acting as a scaffold protein that mediates NF-kappa B signaling. In addition, MALT1 is a cysteine protease that further fine tunes proinflammatory signaling by cleaving specific substrates. Deregulated MALT1 activity has been associated with immunodeficiency, autoimmunity, and cancer in mice and humans. Genetically engineered mice expressing catalytically inactive MALT1, still exerting its scaffold function, were previously shown to spontaneously develop autoimmunity due to a decrease in Tregs associated with increased effector T cell activation. In contrast, complete absence of MALT1 does not lead to autoimmunity, which has been explained by the impaired effector T cell activation due to the absence of MALT1-mediated signaling. However, here we report that MALT1-deficient mice develop atopic-like dermatitis upon aging, which is preceded by Th2 skewing, an increase in serum IgE, and a decrease in Treg frequency and surface expression of the Treg functionality marker CTLA-4.
Keywords
NF-KAPPA-B, PARACASPASE MALT1 CLEAVES, T-CELL, IMMUNE DYSREGULATION, PROTEOLYTIC ACTIVITY, UBIQUITIN LIGASE, EFFECTOR T, ACTIVATION, BCL10, RESPONSES, atopic dermatitis, skin inflammation, MALT1, lymphocytes, Tregs, Th2, aging

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MLA
Demeyer, Annelies, et al. “MALT1-Deficient Mice Develop Atopic-like Dermatitis upon Aging.” FRONTIERS IN IMMUNOLOGY, vol. 10, 2019.
APA
Demeyer, A., Van Nuffel, E., Baudelet, G., Driege, Y., Kreike, M., Muyllaert, D., … Beyaert, R. (2019). MALT1-deficient mice develop atopic-like dermatitis upon aging. FRONTIERS IN IMMUNOLOGY, 10.
Chicago author-date
Demeyer, Annelies, Elien Van Nuffel, Griet Baudelet, Yasmine Driege, Marja Kreike, David Muyllaert, Jens Staal, and Rudi Beyaert. 2019. “MALT1-Deficient Mice Develop Atopic-like Dermatitis upon Aging.” FRONTIERS IN IMMUNOLOGY 10.
Chicago author-date (all authors)
Demeyer, Annelies, Elien Van Nuffel, Griet Baudelet, Yasmine Driege, Marja Kreike, David Muyllaert, Jens Staal, and Rudi Beyaert. 2019. “MALT1-Deficient Mice Develop Atopic-like Dermatitis upon Aging.” FRONTIERS IN IMMUNOLOGY 10.
Vancouver
1.
Demeyer A, Van Nuffel E, Baudelet G, Driege Y, Kreike M, Muyllaert D, et al. MALT1-deficient mice develop atopic-like dermatitis upon aging. FRONTIERS IN IMMUNOLOGY. 2019;10.
IEEE
[1]
A. Demeyer et al., “MALT1-deficient mice develop atopic-like dermatitis upon aging,” FRONTIERS IN IMMUNOLOGY, vol. 10, 2019.
@article{8639687,
  abstract     = {MALT1 plays an important role in innate and adaptive immune signaling by acting as a scaffold protein that mediates NF-kappa B signaling. In addition, MALT1 is a cysteine protease that further fine tunes proinflammatory signaling by cleaving specific substrates. Deregulated MALT1 activity has been associated with immunodeficiency, autoimmunity, and cancer in mice and humans. Genetically engineered mice expressing catalytically inactive MALT1, still exerting its scaffold function, were previously shown to spontaneously develop autoimmunity due to a decrease in Tregs associated with increased effector T cell activation. In contrast, complete absence of MALT1 does not lead to autoimmunity, which has been explained by the impaired effector T cell activation due to the absence of MALT1-mediated signaling. However, here we report that MALT1-deficient mice develop atopic-like dermatitis upon aging, which is preceded by Th2 skewing, an increase in serum IgE, and a decrease in Treg frequency and surface expression of the Treg functionality marker CTLA-4.},
  articleno    = {2330},
  author       = {Demeyer, Annelies and Van Nuffel, Elien and Baudelet, Griet and Driege, Yasmine and Kreike, Marja and Muyllaert, David and Staal, Jens and Beyaert, Rudi},
  issn         = {1664-3224},
  journal      = {FRONTIERS IN IMMUNOLOGY},
  keywords     = {NF-KAPPA-B,PARACASPASE MALT1 CLEAVES,T-CELL,IMMUNE DYSREGULATION,PROTEOLYTIC ACTIVITY,UBIQUITIN LIGASE,EFFECTOR T,ACTIVATION,BCL10,RESPONSES,atopic dermatitis,skin inflammation,MALT1,lymphocytes,Tregs,Th2,aging},
  language     = {eng},
  pages        = {11},
  title        = {MALT1-deficient mice develop atopic-like dermatitis upon aging},
  url          = {http://dx.doi.org/10.3389/fimmu.2019.02330},
  volume       = {10},
  year         = {2019},
}

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