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Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche

Johnny Bonnardel (UGent) , Wouter T'Jonck (UGent) , Djoere Gaublomme (UGent) , Robin Browaeys (UGent) , Charlotte Scott (UGent) , Liesbet Martens (UGent) , Bavo Vanneste (UGent) , Sofie De Prijck (UGent) , Sergei A Nedospasov, Anna Kremer (UGent) , et al.
(2019) IMMUNITY. 51(4). p.638-654
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Abstract
Macrophages are strongly adapted to their tissue of residence. Yet, little is known about the cell-cell interactions that imprint the tissue-specific identities of macrophages in their respective niches. Using conditional depletion of liver Kupffer cells, we traced the developmental stages of monocytes differentiating into Kupffer cells and mapped the cellular interactions imprinting the Kupffer cell identity. Kupffer cell loss induced tumor necrosis factor (TNF)- and interleukin-1 (IL-1) receptor-dependent activation of stellate cells and endothelial cells, resulting in the transient production of chemokines and adhesion molecules orchestrating monocyte engraftment. Engrafted circulating monocytes transmigrated into the perisinusoidal space and acquired the liver-associated transcription factors inhibitor of DNA 3 (ID3) and liver X receptor-alpha (LXR-alpha). Coordinated interactions with hepatocytes induced ID3 expression, whereas endothelial cells and stellate cells induced LXR-alpha via a synergistic NOTCH-BMP pathway. This study shows that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity.
Keywords
GENE-EXPRESSION, TISSUE, SIGNALS, LIGHT

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MLA
Bonnardel, Johnny, et al. “Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.” IMMUNITY, vol. 51, no. 4, 2019, pp. 638–54, doi:10.1016/j.immuni.2019.08.017.
APA
Bonnardel, J., T’Jonck, W., Gaublomme, D., Browaeys, R., Scott, C., Martens, L., … Guilliams, M. (2019). Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche. IMMUNITY, 51(4), 638–654. https://doi.org/10.1016/j.immuni.2019.08.017
Chicago author-date
Bonnardel, Johnny, Wouter T’Jonck, Djoere Gaublomme, Robin Browaeys, Charlotte Scott, Liesbet Martens, Bavo Vanneste, et al. 2019. “Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.” IMMUNITY 51 (4): 638–54. https://doi.org/10.1016/j.immuni.2019.08.017.
Chicago author-date (all authors)
Bonnardel, Johnny, Wouter T’Jonck, Djoere Gaublomme, Robin Browaeys, Charlotte Scott, Liesbet Martens, Bavo Vanneste, Sofie De Prijck, Sergei A Nedospasov, Anna Kremer, Evelien Van Hamme, Peter Borghgraef, Wendy Toussaint, Pieter De Bleser, Inge Mannaerts, Alain Beschin, Leo A van Grunsven, Bart Lambrecht, Tom Taghon, Saskia Lippens, Dirk Elewaut, Yvan Saeys, and Martin Guilliams. 2019. “Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.” IMMUNITY 51 (4): 638–654. doi:10.1016/j.immuni.2019.08.017.
Vancouver
1.
Bonnardel J, T’Jonck W, Gaublomme D, Browaeys R, Scott C, Martens L, et al. Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche. IMMUNITY. 2019;51(4):638–54.
IEEE
[1]
J. Bonnardel et al., “Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche,” IMMUNITY, vol. 51, no. 4, pp. 638–654, 2019.
@article{8639571,
  abstract     = {{Macrophages are strongly adapted to their tissue of residence. Yet, little is known about the cell-cell interactions that imprint the tissue-specific identities of macrophages in their respective niches. Using conditional depletion of liver Kupffer cells, we traced the developmental stages of monocytes differentiating into Kupffer cells and mapped the cellular interactions imprinting the Kupffer cell identity. Kupffer cell loss induced tumor necrosis factor (TNF)- and interleukin-1 (IL-1) receptor-dependent activation of stellate cells and endothelial cells, resulting in the transient production of chemokines and adhesion molecules orchestrating monocyte engraftment. Engrafted circulating monocytes transmigrated into the perisinusoidal space and acquired the liver-associated transcription factors inhibitor of DNA 3 (ID3) and liver X receptor-alpha (LXR-alpha). Coordinated interactions with hepatocytes induced ID3 expression, whereas endothelial cells and stellate cells induced LXR-alpha via a synergistic NOTCH-BMP pathway. This study shows that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity.}},
  author       = {{Bonnardel, Johnny and T'Jonck, Wouter and Gaublomme, Djoere and Browaeys, Robin and Scott, Charlotte and Martens, Liesbet and Vanneste, Bavo and De Prijck, Sofie and Nedospasov, Sergei A and Kremer, Anna and Van Hamme, Evelien and Borghgraef, Peter and Toussaint, Wendy and De Bleser, Pieter and Mannaerts, Inge and Beschin, Alain and van Grunsven, Leo A and Lambrecht, Bart and Taghon, Tom and Lippens, Saskia and Elewaut, Dirk and Saeys, Yvan and Guilliams, Martin}},
  issn         = {{1074-7613}},
  journal      = {{IMMUNITY}},
  keywords     = {{GENE-EXPRESSION,TISSUE,SIGNALS,LIGHT}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{638--654}},
  title        = {{Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche}},
  url          = {{http://dx.doi.org/10.1016/j.immuni.2019.08.017}},
  volume       = {{51}},
  year         = {{2019}},
}

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