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Muscle strength is a major determinant of the blood pressure response to isometric stress testing : the Asklepios population study

Caroline Van daele (UGent) , Julio Chirinos Medina (UGent) , Tim De Meyer (UGent) , Marc De Buyzere (UGent) , Michel Langlois (UGent) , Sofie Bekaert (UGent) , Patrick Segers (UGent) , Thierry Gillebert (UGent) and Ernst Rietzschel (UGent)
(2020) JOURNAL OF HYPERTENSION. 38(2). p.224-234
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Abstract
Aim: Maximal handgrip strength is a strong predictor of cardiovascular mortality in economically and socioculturally diverse countries, yet the main determinants of cardiovascular response to change in afterload during handgrip are not well known. We examined the blood pressure (BP) responses during submaximal handgrip (at 25% of grip strength) and the determinants of grip strength. Methods: We studied 2215 participants from a population-based random sample without overt clinical disease (Asklepios Study; mean age 56.2 years). Handgrip testing was performed using a modified Jamar dynamometer with direct visual feedback. Simultaneously, a validated finger plethysmographic device measured continuous BP and heart rate. Results: During handgrip, SBP and DBP rose by, respectively, 20 +/- 13 and 10 +/- 6 mmHg. These changes were normally distributed and consistently higher in men. The main independent determinants of mean arterial pressure response during handgrip were: grip strength (F = 191.4; P < 0.001), baseline pulse pressure (F = 32.0; P < 0.001), height (F = 16.4; P < 0.001) and age (F = 12.8; P < 0.001). Grip strength was associated with muscle mass, better metabolic health, but also with higher baseline DBP. There was a significant graded increase in maximum pressure achieved and in the magnitude of pressure change during handgrip with increasing BP categories (P for trend <0.001). Conclusion: The population BP response to handgrip is variable and its predominant determinant turned out to be grip strength itself, which should be accounted for in future analyses. Higher baseline BP, even within the normotensive range, acted as an independent and graded predictor of BP increase during handgrip.
Keywords
LEFT-VENTRICULAR MASS, GRIP STRENGTH, HANDGRIP STRENGTH, BODY-COMPOSITION, MUSCULAR STRENGTH, EXERCISE, MORTALITY, HYPERTENSION, ASSOCIATION, ADULTS, blood pressure response, handgrip, isometric stress testing, muscle strength, population study

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MLA
Van daele, Caroline, et al. “Muscle Strength Is a Major Determinant of the Blood Pressure Response to Isometric Stress Testing : The Asklepios Population Study.” JOURNAL OF HYPERTENSION, vol. 38, no. 2, 2020, pp. 224–34, doi:10.1097/HJH.0000000000002272.
APA
Van daele, C., Chirinos Medina, J., De Meyer, T., De Buyzere, M., Langlois, M., Bekaert, S., … Rietzschel, E. (2020). Muscle strength is a major determinant of the blood pressure response to isometric stress testing : the Asklepios population study. JOURNAL OF HYPERTENSION, 38(2), 224–234. https://doi.org/10.1097/HJH.0000000000002272
Chicago author-date
Van daele, Caroline, Julio Chirinos Medina, Tim De Meyer, Marc De Buyzere, Michel Langlois, Sofie Bekaert, Patrick Segers, Thierry Gillebert, and Ernst Rietzschel. 2020. “Muscle Strength Is a Major Determinant of the Blood Pressure Response to Isometric Stress Testing : The Asklepios Population Study.” JOURNAL OF HYPERTENSION 38 (2): 224–34. https://doi.org/10.1097/HJH.0000000000002272.
Chicago author-date (all authors)
Van daele, Caroline, Julio Chirinos Medina, Tim De Meyer, Marc De Buyzere, Michel Langlois, Sofie Bekaert, Patrick Segers, Thierry Gillebert, and Ernst Rietzschel. 2020. “Muscle Strength Is a Major Determinant of the Blood Pressure Response to Isometric Stress Testing : The Asklepios Population Study.” JOURNAL OF HYPERTENSION 38 (2): 224–234. doi:10.1097/HJH.0000000000002272.
Vancouver
1.
Van daele C, Chirinos Medina J, De Meyer T, De Buyzere M, Langlois M, Bekaert S, et al. Muscle strength is a major determinant of the blood pressure response to isometric stress testing : the Asklepios population study. JOURNAL OF HYPERTENSION. 2020;38(2):224–34.
IEEE
[1]
C. Van daele et al., “Muscle strength is a major determinant of the blood pressure response to isometric stress testing : the Asklepios population study,” JOURNAL OF HYPERTENSION, vol. 38, no. 2, pp. 224–234, 2020.
@article{8639181,
  abstract     = {{Aim: Maximal handgrip strength is a strong predictor of cardiovascular mortality in economically and socioculturally diverse countries, yet the main determinants of cardiovascular response to change in afterload during handgrip are not well known. We examined the blood pressure (BP) responses during submaximal handgrip (at 25% of grip strength) and the determinants of grip strength. Methods: We studied 2215 participants from a population-based random sample without overt clinical disease (Asklepios Study; mean age 56.2 years). Handgrip testing was performed using a modified Jamar dynamometer with direct visual feedback. Simultaneously, a validated finger plethysmographic device measured continuous BP and heart rate. Results: During handgrip, SBP and DBP rose by, respectively, 20 +/- 13 and 10 +/- 6 mmHg. These changes were normally distributed and consistently higher in men. The main independent determinants of mean arterial pressure response during handgrip were: grip strength (F = 191.4; P < 0.001), baseline pulse pressure (F = 32.0; P < 0.001), height (F = 16.4; P < 0.001) and age (F = 12.8; P < 0.001). Grip strength was associated with muscle mass, better metabolic health, but also with higher baseline DBP. There was a significant graded increase in maximum pressure achieved and in the magnitude of pressure change during handgrip with increasing BP categories (P for trend <0.001). Conclusion: The population BP response to handgrip is variable and its predominant determinant turned out to be grip strength itself, which should be accounted for in future analyses. Higher baseline BP, even within the normotensive range, acted as an independent and graded predictor of BP increase during handgrip.}},
  author       = {{Van daele, Caroline and Chirinos Medina, Julio and De Meyer, Tim and De Buyzere, Marc and Langlois, Michel and Bekaert, Sofie and Segers, Patrick and Gillebert, Thierry and Rietzschel, Ernst}},
  issn         = {{0263-6352}},
  journal      = {{JOURNAL OF HYPERTENSION}},
  keywords     = {{LEFT-VENTRICULAR MASS,GRIP STRENGTH,HANDGRIP STRENGTH,BODY-COMPOSITION,MUSCULAR STRENGTH,EXERCISE,MORTALITY,HYPERTENSION,ASSOCIATION,ADULTS,blood pressure response,handgrip,isometric stress testing,muscle strength,population study}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{224--234}},
  title        = {{Muscle strength is a major determinant of the blood pressure response to isometric stress testing : the Asklepios population study}},
  url          = {{http://dx.doi.org/10.1097/HJH.0000000000002272}},
  volume       = {{38}},
  year         = {{2020}},
}
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