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Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists

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Abstract
Uncontrolled systemic inflammatory immune triggering has hampered the clinical translation of several classes of small-molecule immunomodulators, such as imidazoquinoline TLR7/8 agonists for vaccine design and cancer immunotherapy. By taking advantage of the inherent serum-protein-binding property of lipid motifs and their tendency to accumulate in lymphoid tissue, we designed amphiphilic lipid-polymer conjugates that suppress systemic inflammation but provoke potent lymph-node immune activation. This work provides a rational basis for the design of lipid-polymer amphiphiles for optimized lymphoid targeting.
Keywords
immunomodulation, innate immunity, lipid amphiphiles, lymph nodes, polymers, RESPONSES, DELIVERY, ENHANCE, 852A

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MLA
De Vrieze, Jana, et al. “Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists.” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 58, no. 43, 2019, pp. 15390–95, doi:10.1002/anie.201905687.
APA
De Vrieze, J., Louage, B., Deswarte, K., Zhong, Z., De Coen, R., Van Herck, S., … De Geest, B. (2019). Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58(43), 15390–15395. https://doi.org/10.1002/anie.201905687
Chicago author-date
De Vrieze, Jana, Benoit Louage, Kim Deswarte, Zifu Zhong, Ruben De Coen, Simon Van Herck, Lutz Nuhn, et al. 2019. “Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists.” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58 (43): 15390–95. https://doi.org/10.1002/anie.201905687.
Chicago author-date (all authors)
De Vrieze, Jana, Benoit Louage, Kim Deswarte, Zifu Zhong, Ruben De Coen, Simon Van Herck, Lutz Nuhn, Camilla Kaas Frich, Alexander N Zelikin, Stefan Lienenklaus, Niek Sanders, Bart Lambrecht, Sunil A David, and Bruno De Geest. 2019. “Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists.” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58 (43): 15390–15395. doi:10.1002/anie.201905687.
Vancouver
1.
De Vrieze J, Louage B, Deswarte K, Zhong Z, De Coen R, Van Herck S, et al. Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2019;58(43):15390–5.
IEEE
[1]
J. De Vrieze et al., “Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists,” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 58, no. 43, pp. 15390–15395, 2019.
@article{8638934,
  abstract     = {{Uncontrolled systemic inflammatory immune triggering has hampered the clinical translation of several classes of small-molecule immunomodulators, such as imidazoquinoline TLR7/8 agonists for vaccine design and cancer immunotherapy. By taking advantage of the inherent serum-protein-binding property of lipid motifs and their tendency to accumulate in lymphoid tissue, we designed amphiphilic lipid-polymer conjugates that suppress systemic inflammation but provoke potent lymph-node immune activation. This work provides a rational basis for the design of lipid-polymer amphiphiles for optimized lymphoid targeting.}},
  author       = {{De Vrieze, Jana and Louage, Benoit and Deswarte, Kim and Zhong, Zifu and De Coen, Ruben and Van Herck, Simon and Nuhn, Lutz and Kaas Frich, Camilla and Zelikin, Alexander N and Lienenklaus, Stefan and Sanders, Niek and Lambrecht, Bart and David, Sunil A and De Geest, Bruno}},
  issn         = {{1433-7851}},
  journal      = {{ANGEWANDTE CHEMIE-INTERNATIONAL EDITION}},
  keywords     = {{immunomodulation,innate immunity,lipid amphiphiles,lymph nodes,polymers,RESPONSES,DELIVERY,ENHANCE,852A}},
  language     = {{eng}},
  number       = {{43}},
  pages        = {{15390--15395}},
  title        = {{Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists}},
  url          = {{http://doi.org/10.1002/anie.201905687}},
  volume       = {{58}},
  year         = {{2019}},
}

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