Effect of novel porphyrazine photosensitizers on normal and tumor brain cells
- Author
- Tatiana A Mishchenko, Victoria D Turubanova, Elena V Mitroshina, Razan Alzeibak, Nina N Peskova, Svetlana A Lermontova, Larisa G Klapshina, Irina V Balalaeva, Maria V Vedunova and Dmitri Krysko (UGent)
- Organization
- Abstract
- Photodynamic therapy (PDT) is a clinically approved procedure for targeting tumor cells. Though several different photosensitizers have been developed, there is still much demand for novel photosensitizers with improved properties. In this study we aim to characterize the accumulation, localization and dark cytotoxicity of the novel photosensitizers developed in-house derivatives of porphyrazines (pz I-IV) in primary murine neuronal cells, as well as to identify the concentrations at which pz still effectively induces death in glioma cells yet is nontoxic to nontransformed cells. The study shows that incubation of primary neuronal and glioma cells with pz I-IV leads to their accumulation in both types of cells, but their rates of internalization, subcellular localization and dark toxicity differ significantly. Pz II was the most promising photosensitizer. It efficiently killed glioma cells while remaining nontoxic to primary neuronal cells. This opens up the possibility of evaluating pz II for experimental PDT for glioma.
- Keywords
- cell death, cytotoxicity, GL261 glioma cells, neurooncology, photodynamic therapy, photosensitizer, primary neuronal cultures KeyWords Plus:PHOTODYNAMIC THERAPY, CANCER, GLIOMA, AGENTS, DEATH, VITRO
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8638918
- MLA
- Mishchenko, Tatiana A., et al. “Effect of Novel Porphyrazine Photosensitizers on Normal and Tumor Brain Cells.” JOURNAL OF BIOPHOTONICS, vol. 13, no. 1, 2020, doi:10.1002/jbio.201960077.
- APA
- Mishchenko, T. A., Turubanova, V. D., Mitroshina, E. V., Alzeibak, R., Peskova, N. N., Lermontova, S. A., … Krysko, D. (2020). Effect of novel porphyrazine photosensitizers on normal and tumor brain cells. JOURNAL OF BIOPHOTONICS, 13(1). https://doi.org/10.1002/jbio.201960077
- Chicago author-date
- Mishchenko, Tatiana A, Victoria D Turubanova, Elena V Mitroshina, Razan Alzeibak, Nina N Peskova, Svetlana A Lermontova, Larisa G Klapshina, Irina V Balalaeva, Maria V Vedunova, and Dmitri Krysko. 2020. “Effect of Novel Porphyrazine Photosensitizers on Normal and Tumor Brain Cells.” JOURNAL OF BIOPHOTONICS 13 (1). https://doi.org/10.1002/jbio.201960077.
- Chicago author-date (all authors)
- Mishchenko, Tatiana A, Victoria D Turubanova, Elena V Mitroshina, Razan Alzeibak, Nina N Peskova, Svetlana A Lermontova, Larisa G Klapshina, Irina V Balalaeva, Maria V Vedunova, and Dmitri Krysko. 2020. “Effect of Novel Porphyrazine Photosensitizers on Normal and Tumor Brain Cells.” JOURNAL OF BIOPHOTONICS 13 (1). doi:10.1002/jbio.201960077.
- Vancouver
- 1.Mishchenko TA, Turubanova VD, Mitroshina EV, Alzeibak R, Peskova NN, Lermontova SA, et al. Effect of novel porphyrazine photosensitizers on normal and tumor brain cells. JOURNAL OF BIOPHOTONICS. 2020;13(1).
- IEEE
- [1]T. A. Mishchenko et al., “Effect of novel porphyrazine photosensitizers on normal and tumor brain cells,” JOURNAL OF BIOPHOTONICS, vol. 13, no. 1, 2020.
@article{8638918,
abstract = {{Photodynamic therapy (PDT) is a clinically approved procedure for targeting tumor cells. Though several different photosensitizers have been developed, there is still much demand for novel photosensitizers with improved properties. In this study we aim to characterize the accumulation, localization and dark cytotoxicity of the novel photosensitizers developed in-house derivatives of porphyrazines (pz I-IV) in primary murine neuronal cells, as well as to identify the concentrations at which pz still effectively induces death in glioma cells yet is nontoxic to nontransformed cells. The study shows that incubation of primary neuronal and glioma cells with pz I-IV leads to their accumulation in both types of cells, but their rates of internalization, subcellular localization and dark toxicity differ significantly. Pz II was the most promising photosensitizer. It efficiently killed glioma cells while remaining nontoxic to primary neuronal cells. This opens up the possibility of evaluating pz II for experimental PDT for glioma.}},
articleno = {{e201960077}},
author = {{Mishchenko, Tatiana A and Turubanova, Victoria D and Mitroshina, Elena V and Alzeibak, Razan and Peskova, Nina N and Lermontova, Svetlana A and Klapshina, Larisa G and Balalaeva, Irina V and Vedunova, Maria V and Krysko, Dmitri}},
issn = {{1864-063X}},
journal = {{JOURNAL OF BIOPHOTONICS}},
keywords = {{cell death,cytotoxicity,GL261 glioma cells,neurooncology,photodynamic therapy,photosensitizer,primary neuronal cultures KeyWords Plus:PHOTODYNAMIC THERAPY,CANCER,GLIOMA,AGENTS,DEATH,VITRO}},
language = {{eng}},
number = {{1}},
pages = {{9}},
title = {{Effect of novel porphyrazine photosensitizers on normal and tumor brain cells}},
url = {{http://dx.doi.org/10.1002/jbio.201960077}},
volume = {{13}},
year = {{2020}},
}
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