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Thermoresponsive hydrogels formed by poly(2-oxazoline) triblock copolymers

Bryn Monnery (UGent) and Richard Hoogenboom (UGent)
(2019) POLYMER CHEMISTRY. 10(25). p.3480-3487
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Abstract
Hydrogels are useful materials for drug delivery and tissue engineering. A subset of these are responsive hydrogelators that are liquids until a stimulus triggers their gelation. Poly(2-oxazoline)s with moderately hydrophobic side chains, such as ethyl and propyl, are inherently thermoresponsive exhibiting lower critical solution temperature behavior. However, previous attempts to make thermoresponsive poly(2-oxazoline) block copolymer hydrogelators have all failed. In this work we report the first working thermoresponsive poly(2-oxazoline) hydrogelator based on ABA triblock copolymers with thermoresponsive outer blocks composed of poly(2-n-propyl-2-oxazoline) and a more hydrophilic poly(2-ethyl-2-oxazoline) inner block that can form hydrogels upon heating an aqueous solution. It was found that thermoresponsive hydrogels are only formed if the block size is tuned to adjust the cloud point temperature and, presumably, to allow sufficient flexibility to non-covalently crosslink the flower-like micelles that these materials form. These triblocks copoly(2-oxazoline)s formed relatively soft thermoresponsive hydrogels that could be suitable for drug release and cell culture applications.
Keywords
CRITICAL SOLUTION TEMPERATURE, BIOMEDICAL APPLICATIONS, BEHAVIOR, POLY(2-ISOPROPYL-2-OXAZOLINE), POLYMERIZATION, DELIVERY, GRADIENT, LCST

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MLA
Monnery, Bryn, and Richard Hoogenboom. “Thermoresponsive Hydrogels Formed by Poly(2-Oxazoline) Triblock Copolymers.” POLYMER CHEMISTRY, vol. 10, no. 25, 2019, pp. 3480–87.
APA
Monnery, B., & Hoogenboom, R. (2019). Thermoresponsive hydrogels formed by poly(2-oxazoline) triblock copolymers. POLYMER CHEMISTRY, 10(25), 3480–3487.
Chicago author-date
Monnery, Bryn, and Richard Hoogenboom. 2019. “Thermoresponsive Hydrogels Formed by Poly(2-Oxazoline) Triblock Copolymers.” POLYMER CHEMISTRY 10 (25): 3480–87.
Chicago author-date (all authors)
Monnery, Bryn, and Richard Hoogenboom. 2019. “Thermoresponsive Hydrogels Formed by Poly(2-Oxazoline) Triblock Copolymers.” POLYMER CHEMISTRY 10 (25): 3480–3487.
Vancouver
1.
Monnery B, Hoogenboom R. Thermoresponsive hydrogels formed by poly(2-oxazoline) triblock copolymers. POLYMER CHEMISTRY. 2019;10(25):3480–7.
IEEE
[1]
B. Monnery and R. Hoogenboom, “Thermoresponsive hydrogels formed by poly(2-oxazoline) triblock copolymers,” POLYMER CHEMISTRY, vol. 10, no. 25, pp. 3480–3487, 2019.
@article{8638866,
  abstract     = {Hydrogels are useful materials for drug delivery and tissue engineering. A subset of these are responsive hydrogelators that are liquids until a stimulus triggers their gelation. Poly(2-oxazoline)s with moderately hydrophobic side chains, such as ethyl and propyl, are inherently thermoresponsive exhibiting lower critical solution temperature behavior. However, previous attempts to make thermoresponsive poly(2-oxazoline) block copolymer hydrogelators have all failed. In this work we report the first working thermoresponsive poly(2-oxazoline) hydrogelator based on ABA triblock copolymers with thermoresponsive outer blocks composed of poly(2-n-propyl-2-oxazoline) and a more hydrophilic poly(2-ethyl-2-oxazoline) inner block that can form hydrogels upon heating an aqueous solution. It was found that thermoresponsive hydrogels are only formed if the block size is tuned to adjust the cloud point temperature and, presumably, to allow sufficient flexibility to non-covalently crosslink the flower-like micelles that these materials form. These triblocks copoly(2-oxazoline)s formed relatively soft thermoresponsive hydrogels that could be suitable for drug release and cell culture applications.},
  author       = {Monnery, Bryn and Hoogenboom, Richard},
  issn         = {1759-9954},
  journal      = {POLYMER CHEMISTRY},
  keywords     = {CRITICAL SOLUTION TEMPERATURE,BIOMEDICAL APPLICATIONS,BEHAVIOR,POLY(2-ISOPROPYL-2-OXAZOLINE),POLYMERIZATION,DELIVERY,GRADIENT,LCST},
  language     = {eng},
  number       = {25},
  pages        = {3480--3487},
  title        = {Thermoresponsive hydrogels formed by poly(2-oxazoline) triblock copolymers},
  url          = {http://dx.doi.org/10.1039/c9py00300b},
  volume       = {10},
  year         = {2019},
}

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