Advanced search
1 file | 5.73 MB Add to list

Counteracting in vitro toxicity of the ionophoric mycotoxin beauvericin : synthetic receptors to the rescue

Vincent Ornelis (UGent) , Andreja Rajkovic (UGent) , Marlies Decleer (UGent) , Benedikt Sas (UGent) , Sarah De Saeger (UGent) and Annemieke Madder (UGent)
(2019) JOURNAL OF ORGANIC CHEMISTRY. 84(16). p.10422-10435
Author
Organization
Abstract
Beauvericin (BEA) and enniatins are toxic ionophoric cyclodepsipeptides that mainly occur in grains. As such, their presence in food commodities poses a concern for public health. To date, despite recent European Food Safety Authority emphasis on the need for more data to evaluate long-term toxicity effects, no suitable affinity reagents are available to detect the presence of BEA and derivatives in food samples. We here report on the synthesis of a small library of artificial receptors with varying cavity sizes and different hydrophobic building blocks. Immobilization of one of the receptors on solid support resulted in a strong retention of beauvericin, thus revealing promising properties as solid-phase extraction material for sample pretreatment. Furthermore, treatment of HepG2 cells with the most promising receptor markedly reduced beauvericin-induced cytotoxicity, hinting toward the possibility of using synthetic receptors as antidotes against ionophoric toxins.
Keywords
ENNIATINS, BINDING, ASSAY, FOOD, RECOGNITION, DERIVATIVES, TOXIN, MAIZE, CELLS, A1

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 5.73 MB

Citation

Please use this url to cite or link to this publication:

MLA
Ornelis, Vincent, et al. “Counteracting in Vitro Toxicity of the Ionophoric Mycotoxin Beauvericin : Synthetic Receptors to the Rescue.” JOURNAL OF ORGANIC CHEMISTRY, vol. 84, no. 16, 2019, pp. 10422–35.
APA
Ornelis, V., Rajkovic, A., Decleer, M., Sas, B., De Saeger, S., & Madder, A. (2019). Counteracting in vitro toxicity of the ionophoric mycotoxin beauvericin : synthetic receptors to the rescue. JOURNAL OF ORGANIC CHEMISTRY, 84(16), 10422–10435.
Chicago author-date
Ornelis, Vincent, Andreja Rajkovic, Marlies Decleer, Benedikt Sas, Sarah De Saeger, and Annemieke Madder. 2019. “Counteracting in Vitro Toxicity of the Ionophoric Mycotoxin Beauvericin : Synthetic Receptors to the Rescue.” JOURNAL OF ORGANIC CHEMISTRY 84 (16): 10422–35.
Chicago author-date (all authors)
Ornelis, Vincent, Andreja Rajkovic, Marlies Decleer, Benedikt Sas, Sarah De Saeger, and Annemieke Madder. 2019. “Counteracting in Vitro Toxicity of the Ionophoric Mycotoxin Beauvericin : Synthetic Receptors to the Rescue.” JOURNAL OF ORGANIC CHEMISTRY 84 (16): 10422–10435.
Vancouver
1.
Ornelis V, Rajkovic A, Decleer M, Sas B, De Saeger S, Madder A. Counteracting in vitro toxicity of the ionophoric mycotoxin beauvericin : synthetic receptors to the rescue. JOURNAL OF ORGANIC CHEMISTRY. 2019;84(16):10422–35.
IEEE
[1]
V. Ornelis, A. Rajkovic, M. Decleer, B. Sas, S. De Saeger, and A. Madder, “Counteracting in vitro toxicity of the ionophoric mycotoxin beauvericin : synthetic receptors to the rescue,” JOURNAL OF ORGANIC CHEMISTRY, vol. 84, no. 16, pp. 10422–10435, 2019.
@article{8638793,
  abstract     = {Beauvericin (BEA) and enniatins are toxic ionophoric cyclodepsipeptides that mainly occur in grains. As such, their presence in food commodities poses a concern for public health. To date, despite recent European Food Safety Authority emphasis on the need for more data to evaluate long-term toxicity effects, no suitable affinity reagents are available to detect the presence of BEA and derivatives in food samples. We here report on the synthesis of a small library of artificial receptors with varying cavity sizes and different hydrophobic building blocks. Immobilization of one of the receptors on solid support resulted in a strong retention of beauvericin, thus revealing promising properties as solid-phase extraction material for sample pretreatment. Furthermore, treatment of HepG2 cells with the most promising receptor markedly reduced beauvericin-induced cytotoxicity, hinting toward the possibility of using synthetic receptors as antidotes against ionophoric toxins.},
  author       = {Ornelis, Vincent and Rajkovic, Andreja and Decleer, Marlies and Sas, Benedikt and De Saeger, Sarah and Madder, Annemieke},
  issn         = {0022-3263},
  journal      = {JOURNAL OF ORGANIC CHEMISTRY},
  keywords     = {ENNIATINS,BINDING,ASSAY,FOOD,RECOGNITION,DERIVATIVES,TOXIN,MAIZE,CELLS,A1},
  language     = {eng},
  number       = {16},
  pages        = {10422--10435},
  title        = {Counteracting in vitro toxicity of the ionophoric mycotoxin beauvericin : synthetic receptors to the rescue},
  url          = {http://dx.doi.org/10.1021/acs.joc.9b01665},
  volume       = {84},
  year         = {2019},
}

Altmetric
View in Altmetric
Web of Science
Times cited: