Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization
- Author
- Henri De Greve, Vikram Virdi (UGent) , Shruti Bakshi and Anna Depicker (UGent)
- Organization
- Abstract
- Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins. These simplified single-gene encoded antibodies are much easier to manufacture and can be produced in plants and in yeast for bulk applications. These merits enable novel passive immunization applications, such as in-feed oral delivery of VHH-IgAs, which have successfully provided protection against a gastrointestinal infection in the piglet model.
- Keywords
- Biotechnology, Bioengineering, Biomedical Engineering
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8637798
- MLA
- De Greve, Henri, et al. “Simplified Monomeric VHH-Fc Antibodies Provide New Opportunities for Passive Immunization.” CURRENT OPINION IN BIOTECHNOLOGY, vol. 61, 2020, pp. 96–101, doi:10.1016/j.copbio.2019.11.006.
- APA
- De Greve, H., Virdi, V., Bakshi, S., & Depicker, A. (2020). Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization. CURRENT OPINION IN BIOTECHNOLOGY, 61, 96–101. https://doi.org/10.1016/j.copbio.2019.11.006
- Chicago author-date
- De Greve, Henri, Vikram Virdi, Shruti Bakshi, and Anna Depicker. 2020. “Simplified Monomeric VHH-Fc Antibodies Provide New Opportunities for Passive Immunization.” CURRENT OPINION IN BIOTECHNOLOGY 61: 96–101. https://doi.org/10.1016/j.copbio.2019.11.006.
- Chicago author-date (all authors)
- De Greve, Henri, Vikram Virdi, Shruti Bakshi, and Anna Depicker. 2020. “Simplified Monomeric VHH-Fc Antibodies Provide New Opportunities for Passive Immunization.” CURRENT OPINION IN BIOTECHNOLOGY 61: 96–101. doi:10.1016/j.copbio.2019.11.006.
- Vancouver
- 1.De Greve H, Virdi V, Bakshi S, Depicker A. Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization. CURRENT OPINION IN BIOTECHNOLOGY. 2020;61:96–101.
- IEEE
- [1]H. De Greve, V. Virdi, S. Bakshi, and A. Depicker, “Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization,” CURRENT OPINION IN BIOTECHNOLOGY, vol. 61, pp. 96–101, 2020.
@article{8637798,
abstract = {{Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins. These simplified single-gene encoded antibodies are much easier to manufacture and can be produced in plants and in yeast for bulk applications. These merits enable novel passive immunization applications, such as in-feed oral delivery of VHH-IgAs, which have successfully provided protection against a gastrointestinal infection in the piglet model.}},
author = {{De Greve, Henri and Virdi, Vikram and Bakshi, Shruti and Depicker, Anna}},
issn = {{0958-1669}},
journal = {{CURRENT OPINION IN BIOTECHNOLOGY}},
keywords = {{Biotechnology,Bioengineering,Biomedical Engineering}},
language = {{eng}},
pages = {{96--101}},
title = {{Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization}},
url = {{http://doi.org/10.1016/j.copbio.2019.11.006}},
volume = {{61}},
year = {{2020}},
}
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