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Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization

Henri De Greve, Vikram Virdi (UGent) , Shruti Bakshi (UGent) and Anna Depicker (UGent)
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Abstract
Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins. These simplified single-gene encoded antibodies are much easier to manufacture and can be produced in plants and in yeast for bulk applications. These merits enable novel passive immunization applications, such as in-feed oral delivery of VHH-IgAs, which have successfully provided protection against a gastrointestinal infection in the piglet model.
Keywords
Biotechnology, Bioengineering, Biomedical Engineering

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Citation

Please use this url to cite or link to this publication:

MLA
De Greve, Henri, et al. “Simplified Monomeric VHH-Fc Antibodies Provide New Opportunities for Passive Immunization.” CURRENT OPINION IN BIOTECHNOLOGY, edited by Ralf Reski et al., vol. 61, 2020, pp. 96–101.
APA
De Greve, H., Virdi, V., Bakshi, S., & Depicker, A. (2020). Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization. CURRENT OPINION IN BIOTECHNOLOGY, 61, 96–101.
Chicago author-date
De Greve, Henri, Vikram Virdi, Shruti Bakshi, and Anna Depicker. 2020. “Simplified Monomeric VHH-Fc Antibodies Provide New Opportunities for Passive Immunization.” Edited by Ralf Reski, Gary Foster, and Ed Rybicki. CURRENT OPINION IN BIOTECHNOLOGY 61: 96–101.
Chicago author-date (all authors)
De Greve, Henri, Vikram Virdi, Shruti Bakshi, and Anna Depicker. 2020. “Simplified Monomeric VHH-Fc Antibodies Provide New Opportunities for Passive Immunization.” Ed by. Ralf Reski, Gary Foster, and Ed Rybicki. CURRENT OPINION IN BIOTECHNOLOGY 61: 96–101.
Vancouver
1.
De Greve H, Virdi V, Bakshi S, Depicker A. Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization. Reski R, Foster G, Rybicki E, editors. CURRENT OPINION IN BIOTECHNOLOGY. 2020;61:96–101.
IEEE
[1]
H. De Greve, V. Virdi, S. Bakshi, and A. Depicker, “Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization,” CURRENT OPINION IN BIOTECHNOLOGY, vol. 61, pp. 96–101, 2020.
@article{8637798,
  abstract     = {Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins. These simplified single-gene encoded antibodies are much easier to manufacture and can be produced in plants and in yeast for bulk applications. These merits enable novel passive immunization applications, such as in-feed oral delivery of VHH-IgAs, which have successfully provided protection against a gastrointestinal infection in the piglet model.},
  author       = {De Greve, Henri and Virdi, Vikram and Bakshi, Shruti and Depicker, Anna},
  editor       = {Reski, Ralf and Foster, Gary and Rybicki, Ed},
  issn         = {0958-1669},
  journal      = {CURRENT OPINION IN BIOTECHNOLOGY},
  keywords     = {Biotechnology,Bioengineering,Biomedical Engineering},
  language     = {eng},
  pages        = {96--101},
  title        = {Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization},
  url          = {http://dx.doi.org/10.1016/j.copbio.2019.11.006},
  volume       = {61},
  year         = {2020},
}

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