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Fragmented dosing of β-alanine induces a body weight-independent pharmacokinetic response

(2019) NUTRIENTS. 11(12).
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Abstract
Personalised dosing of performance-enhancing food supplements is a hot topic. β-alanine is currently dosed using a fixed dose; however, evidence suggests that this might favour light compared to heavy subjects. A weight-relative dose seems to reverse this problem. In the present study, a novel dosing strategy was tested. A fragmented dose, composed of a fixed fragment of 800 mg and a weight-relative fragment of 10 mg/kg body weight, was compared to a fixed dose of 1600 mg and a weight-relative dose of 20 mg/kg body weight in a cohort of 20 subjects with a body weight ranging 48–139 kg (79.9 ± 24.4 kg). The results show that, following a fragmented dose, the influence of body weight on the pharmacokinetic response (iAUC) over a 210 min period was absent (r = −0.168; p = 0.478), in contrast to the fixed or weight-relative dose. The pharmacokinetic response also seemed more homogenous (CV% = 26%) following a fragmented dose compared to the fixed (33%) and the weight-relative dose (31%). The primary advantage of the easy-to-calculate fragmented dosing strategy is that it does not systematically favour or impair a certain weight group. Thorough dosage studies are lacking in the current field of sports and food supplements, therefore similar considerations can be made towards other (ergogenic) food supplements.
Keywords
Exercise physiology and nutrition, Food Science, beta-alanine, carnosine, ergogenic, food supplement, personalised nutrition

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MLA
Stautemas, Jan, et al. “Fragmented Dosing of β-Alanine Induces a Body Weight-Independent Pharmacokinetic Response.” NUTRIENTS, vol. 11, no. 12, 2019.
APA
Stautemas, J., Van de Loock, A., Van der Stede, T., Pringels, L., & Derave, W. (2019). Fragmented dosing of β-alanine induces a body weight-independent pharmacokinetic response. NUTRIENTS, 11(12).
Chicago author-date
Stautemas, Jan, Alexia Van de Loock, Thibaux Van der Stede, Lauren Pringels, and Wim Derave. 2019. “Fragmented Dosing of β-Alanine Induces a Body Weight-Independent Pharmacokinetic Response.” NUTRIENTS 11 (12).
Chicago author-date (all authors)
Stautemas, Jan, Alexia Van de Loock, Thibaux Van der Stede, Lauren Pringels, and Wim Derave. 2019. “Fragmented Dosing of β-Alanine Induces a Body Weight-Independent Pharmacokinetic Response.” NUTRIENTS 11 (12).
Vancouver
1.
Stautemas J, Van de Loock A, Van der Stede T, Pringels L, Derave W. Fragmented dosing of β-alanine induces a body weight-independent pharmacokinetic response. NUTRIENTS. 2019;11(12).
IEEE
[1]
J. Stautemas, A. Van de Loock, T. Van der Stede, L. Pringels, and W. Derave, “Fragmented dosing of β-alanine induces a body weight-independent pharmacokinetic response,” NUTRIENTS, vol. 11, no. 12, 2019.
@article{8637786,
  abstract     = {Personalised dosing of performance-enhancing food supplements is a hot topic. β-alanine is currently dosed using a fixed dose; however, evidence suggests that this might favour light compared to heavy subjects. A weight-relative dose seems to reverse this problem. In the present study, a novel dosing strategy was tested. A fragmented dose, composed of a fixed fragment of 800 mg and a weight-relative fragment of 10 mg/kg body weight, was compared to a fixed dose of 1600 mg and a weight-relative dose of 20 mg/kg body weight in a cohort of 20 subjects with a body weight ranging 48–139 kg (79.9 ± 24.4 kg). The results show that, following a fragmented dose, the influence of body weight on the pharmacokinetic response (iAUC) over a 210 min period was absent (r = −0.168; p = 0.478), in contrast to the fixed or weight-relative dose. The pharmacokinetic response also seemed more homogenous (CV% = 26%) following a fragmented dose compared to the fixed (33%) and the weight-relative dose (31%). The primary advantage of the easy-to-calculate fragmented dosing strategy is that it does not systematically favour or impair a certain weight group. Thorough dosage studies are lacking in the current field of sports and food supplements, therefore similar considerations can be made towards other (ergogenic) food supplements.},
  articleno    = {2869},
  author       = {Stautemas, Jan and Van de Loock, Alexia and Van der Stede, Thibaux and Pringels, Lauren and Derave, Wim},
  issn         = {2072-6643},
  journal      = {NUTRIENTS},
  keywords     = {Exercise physiology and nutrition,Food Science,beta-alanine,carnosine,ergogenic,food supplement,personalised nutrition},
  language     = {eng},
  number       = {12},
  pages        = {11},
  title        = {Fragmented dosing of β-alanine induces a body weight-independent pharmacokinetic response},
  url          = {http://dx.doi.org/10.3390/nu11122869},
  volume       = {11},
  year         = {2019},
}

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