@article{8636523,
  abstract     = {{Background: Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered to have low disease severity and favorable outcomes. They represent a relatively poorly characterized population that was only classified as having acute respiratory distress syndrome in the most recent definition. Our primary objective was to describe the natural course and the factors associated with worsening and mortality in this population. 
Methods: This study analyzed patients from the international prospective Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) who had initial mild acute respiratory distress syndrome in the first day of inclusion. This study defined three groups based on the evolution of severity in the first week: " worsening" if moderate or severe acute respiratory distress syndrome criteria were met, " persisting" if mild acute respiratory distress syndrome criteria were the most severe category, and " improving" if patients did not fulfill acute respiratory distress syndrome criteria any more from day 2. 
Results: Among 580 patients with initial mild acute respiratory distress syndrome, 18% (103 of 580) continuously improved, 36% (210 of 580) had persisting mild acute respiratory distress syndrome, and 46% (267 of 580) worsened in the first week after acute respiratory distress syndrome onset. Global in-hospital mortality was 30% (172 of 576; specifically 10% [10 of 101], 30% [63 of 210], and 37% [99 of 265] for patients with improving, persisting, and worsening acute respiratory distress syndrome, respectively), and the median (interquartile range) duration of mechanical ventilation was 7 (4, 14) days (specifically 3 [2, 5], 7 [4, 14], and 11 [6, 18] days for patients with improving, persisting, and worsening acute respiratory distress syndrome, respectively). Admissions for trauma or pneumonia, higher nonpulmonary sequential organ failure assessment score, lower partial pressure of alveolar oxygen/fraction of inspired oxygen, and higher peak inspiratory pressure were independently associated with worsening. 
Conclusions: Most patients with initial mild acute respiratory distress syndrome continue to fulfill acute respiratory distress syndrome criteria in the first week, and nearly half worsen in severity. Their mortality is high, particularly in patients with worsening acute respiratory distress syndrome, emphasizing the need for close attention to this patient population.}},
  author       = {{Pham, Tài and Serpa Neto, Ary and Pelosi, Paolo and Laffey, John Gerard and De Haro, Candelaria and Lorente, Jose Angel and Bellani, Giacomo and Fan, Eddy and Brochard, Laurent Jean and Pesenti, Antonio and Schultz, Marcus Josephus and Artigas, Antonio and Esteban, Andres and Gattinoni, Luciano and van Haren, Frank and Larsson, Anders and McAuley, Daniel F. and Ranieri, Marco and Rubenfeld, Gordon and Thompson, B. Taylor and Wrigge, Hermann and Slutsky, Arthur S. and Rios, Fernando and Van Haren, Frank and Sottiaux, Thierry and Lora, Fredy S. and Gonzalez, Marcos and Silesky, Juan and Cerny, Vladimir and Nielsen, Jonas and Jibaja, Manuel and Wrigge, Hermann and Matamis, Dimitrios and Ranero, Jorge Luis and Amin, Pravin and Hashemian, S.M. and Clarkson, Kevin and Kurahashi, Kiyoyasu and Villagomez, Asisclo and Zeggwagh, Amine Ali and Heunks, Leo M. and Laake, Jon Henrik and Palo, Jose Emmanuel and do Vale Fernandes, Antero and Sandesc, Dorel and Arabi, Yaasen and Bumbasierevic, Vesna and Nin, Nicolas and Larsson, Anders and Piquilloud, Lise and Abroug, Fekri and McAuley, Daniel F. and McNamee, Lia and Hurtado, Javier and Bajwa, Ed and Démpaire, Gabriel and Sula, Hektor and Nunci, Lordian and Cani, Alma and Zazu, Alan and Dellera, Christian and Insaurralde, Carolina S. and Alejandro, Risso V. and Daldin, Julio and Vinzio, Mauricio and Fernandez, Ruben O. and Cardonnet, Luis P. and Bettini, Lisandro R. and Bisso, Mariano Carboni and Osman, Emilio M. and Setten, Mariano G. and Lovazzano, Pablo and Alvarez, Javier and Villar, Veronica and Pozo, Norberto C. and Grubissich, Nicolas and Plotnikow, Gustavo A. and Vasquez, Daniela N. and Ilutovich, Santiago and Tiribelli, Norberto and Chena, Ariel and Pellegrini, Carlos A. and Saenz, María G. and Estenssoro, Elisa and Brizuela, Matias and Gianinetto, Hernan and Gomez, Pablo E. and Cerrato, Valeria I. and Bezzi, Marco G. and Borello, Silvina A. and Loiacono, Flavia A. and Fernandez, Adriana M. and Knowles, Serena and Reynolds, Claire and Inskip, Deborah M. and Miller, Jennene J. and Kong, Jing and Whitehead, Christina and Bihari, Shailesh and Seven, Aylin and Krstevski, Amanda and Rodgers, Helen J. and Millar, Rebecca T. and Mckenna, Toni E. and Bailey, Irene M. and Hanlon, Gabrielle C. and Aneman, Anders and Lynch, Joan M. and Azad, Raman and Neal, John and Woods, Paul W. and Roberts, Brigit L. and Kol, Mark R. and Wong, Helen S. and Riss, Katharina C. and Staudinger, Thomas and Wittebole, Xavier and Berghe, Caroline and Bulpa, Pierre A. and Dive, Alain M. and Verstraete, Rik and Lebbinck, Herve and Depuydt, Pieter and Vermassen, Joris and Meersseman, Philippe and Ceunen, Helga and Rosa, Jonas I. and Beraldo, Daniel O. and Piras, Claudio and Rampinelli, Adenilton M. and Nassar, Antonio P. and Mataloun, Sergio and Moock, Marcelo and Thompson, Marlus M. and Gonçalves, Claudio H. and Antônio, Ana Carolina P. and Ascoli, Aline and Biondi, Rodrigo S. and Fontenele, Danielle C. and Nobrega, Danielle and Sales, Vanessa M. and Bin HJ Abul Wahab, Ahmad Yazid and Ismail, Maizatul and Shindhe, Suresh and Beloncle, Francois and Davies, Kyle G. and Cirone, Rob and Manoharan, Venika and Ismail, Mehvish and Goligher, Ewan C. and Jassal, Mandeep and Nishikawa, Erin and Javeed, Areej and Curley, Gerard and Rittayamai, Nuttapol and Parotto, Matteo and Ferguson, Niall D. and Mehta, Sangeeta and Knoll, Jenny and Pronovost, Antoine and Canestrini, Sergio and Bruhn, Alejandro R. and Garcia, Patricio H. and Aliaga, Felipe A. and Farías, Pamela A. and Yumha, Jacob S. and Ortiz, Claudia A. and Salas, Javier E. and Saez, Alejandro A. and Vega, Luis D. and Labarca, Eduardo F. and Martinez, Felipe T. and Carreño, Nicolás G. and Lora, Pilar and Liu, Haitao and Qiu, Haibo and Liu, Ling and Tang, Rui/ and Luo, Xiaoming and An, Youzhong and Zhao, Huiying and Gao, Yan and Zhai, Zhe and Ye, Zheng L. and Wang, Wei and Li, Wenwen and Li, Qingdong and Zheng, Ruiqiang and Yu, Wenkui and Shen, Juanhong and Li, Xinyu and Yu, Tao and Lu, Weihua and Wu, Ya Q. and Huang, Xiao B. and He, Zhenyang and Lu, Yuanhua and Han, Hui and Zhang, Fan and Sun, Renhua and Wang, Hua X. and Qin, Shu H. and Zhu, Bao H. and Zhao, Jun and Liu, Jian and Li, Bin and Liu, Jing L. and Zhou, Fa C. and Li, Qiong J. and Zhang, Xing Y. and Li-Xin, Zhou and Xin-Hua, Qiang and Jiang, Liangyan and Gao, Yuan N. and Zhao, Xian Y. and Li, Yuan Y. and Li, Xiao L. and Wang, Chunting and Yao, Qingchun and Yu, Rongguo and Chen, Kai and Shao, Huanzhang and Qin, Bingyu and Huang, Qing Q. and Zhu, Wei H. and Hang, Ai Y. and Hua, Ma X. and Li, Yimin and Xu, Yonghao and Di, Yu D. and Ling, Long L. and Qin, Tie H. and Wang, Shou H. and Qin, Junping and Han, Yi and Zhou, Suming and Vargas, Monica P. and Silesky Jimenez, Juan I. and González Rojas, Manuel A. and Solis-Quesada, Jaime E. and Ramirez-Alfaro, Christian M. and Máca, Jan and Sklienka, Peter and Gjedsted, Jakob and Christiansen, Aage and Nielsen, Jonas and Villamagua, Boris G. and Llano, Miguel and Burtin, Philippe and Buzancais, Gautier and Beuret, Pascal and Pelletier, Nicolas and Mortaza, Satar and Mercat, Alain and Chelly, Jonathan and Jochmans, Sébastien and Terzi, Nicolas and Daubin, Cédric and Carteaux, Guillaume and de Prost, Nicolas and Chiche, Jean-Daniel and Daviaud, Fabrice and Fartoukh, Muriel and Barberet, Guillaume and Biehler, Jerome and Dellamonica, Jean and Doyen, Denis and Arnal, Jean-Michel and Briquet, Anais and Hraiech, Sami and Papazian, Laurent and Follin, Arnaud and Roux, Damien and Messika, Jonathan and Kalaitzis, Evangelos and Dangers, Laurence and Combes, Alain and Au, Siu-Ming and Béduneau, Gaetan and Carpentier, Dorothée and Zogheib, Elie H. and Dupont, Herve and Ricome, Sylvie and Santoli, Francesco L. and Besset, Sebastien L. and Michel, Philippe and Gelée, Bruno and Danin, Pierre-Eric and Goubaux, Bernard and Crova, Philippe J. and Phan, Nga T. and Berkelmans, Frantz and Badie, Julio C. and Tapponnier, Romain and Gally, Josette and Khebbeb, Samy and Herbrecht, Jean-Etienne and Schneider, Francis and Declercq, Pierre-Louis M. and Rigaud, Jean-Philippe and Duranteau, Jacques and Harrois, Anatole and Chabanne, Russell and Marin, Julien and Bigot, Charlene and Thibault, Sandrine and Ghazi, Mohammed and Boukhazna, Messabi and Zein, Salem Ould and Richecoeur, Jack R. and Combaux, Daniele M. and Grelon, Fabien and Moal, Charlene Le and Sauvadet, Elise P. and Robine, Adrien and Lemiale, Virginie and Reuter, Danielle and Dres, Martin and Demoule, Alexandre and Goldgran-Toledano, Dany and Baboi, Loredana and Guérin, Claude and Lohner, Ralph and Kraßler, Jens and Schäfer, Susanne and Zacharowski, Kai D. and Meybohm, Patrick and Reske, Andreas W. and Simon, Philipp and Hopf, Hans-Bernd F. and Schuetz, Michael and Baltus, Thomas and Papanikolaou, Metaxia N. and Papavasilopoulou, Theonymfi G. and Zacharas, Giannis A. and Ourailogloy, Vasilis and Mouloudi, Eleni K. and Massa, Eleni V. and Nagy, Eva O. and Stamou, Electra E. and Kiourtzieva, Ellada V. and Oikonomou, Marina A. and Avila, Luis E. and Cortez, Cesar A. and Citalán, Johanna E. and Jog, Sameer A. and Sable, Safal D. and Shah, Bhagyesh and Gurjar, Mohan and Baronia, Arvind K. and Memon, Mohammedfaruk and Muthuchellappan, Radhakrishnan and Ramesh, Venkatapura J. and Shenoy, Anitha and Unnikrishnan, Ramesh and Dixit, Subhal B. and Rhayakar, Rachana V. and Ramakrishnan, Nagarajan and Bhardwaj, Vallish K. and Mahto, Heera L. and Sagar, Sudha V. and Palaniswamy, Vijayanand and Ganesan, Deeban and Hashemian, Seyed Mohammadreza and Jamaati, Hamidreza and Heidari, Farshad and Meaney, Edel A. and Nichol, Alistair and Knapman, Karl M. and O’Croinin, Donall and Dunne, Eimhin S. and Breen, Dorothy M. and Clarkson, Kevin P. and Jaafar, Rola F. and Dwyer, Rory and Amir, Fahd and Ajetunmobi, Olaitan O. and O’Muircheartaigh, Aogan C. and Black, Colin S. and Treanor, Nuala and Collins, Daniel V. and Altaf, Wahid and Zani, Gianluca and Fusari, Maurizio and Spadaro, Savino and Volta, Carlo A. and Graziani, Romano and Brunettini, Barbara and Palmese, Salvatore and Formenti, Paolo and Umbrello, Michele and Lombardo, Andrea and Pecci, Elisabetta and Botteri, Marco and Savioli, Monica and Protti, Alessandro and Mattei, Alessia and Schiavoni, Lorenzo and Tinnirello, Andrea and Todeschini, Manuel and Giarratano, Antonino and Cortegiani, Andrea and Sher, Sara and Rossi, Anna and Antonelli, Massimo M. and Montini, Luca M. and Casalena, Paolo and Scafetti, Sergio and Panarello, Giovanna and Occhipinti, Giovanna and Patroniti, Nicolò and Pozzi, Matteo and Biscione, Roberto R. and Poli, Michela M. and Raimondi, Ferdinando and Albiero, Daniela and Crapelli, Giulia and Beck, Eduardo and Pota, Vincenzo and Schiavone, Vincenzo and Molin, Alexandre and Tarantino, Fabio and Monti, Giacomo and Frati, Elena and Mirabella, Lucia and Cinnella, Gilda and Fossali, Tommaso and Colombo, Riccardo and Pattarino, Pierpaolo Terragni Ilaria and Mojoli, Francesco and Braschi, Antonio and Borotto, Erika E. and Cracchiolo, Andrea N. and Palma, Daniela M. and Raponi, Francesco and Foti, Giuseppe and Vascotto, Ettore R. and Coppadoro, Andrea and Brazzi, Luca and Floris, Leda and Iotti, Giorgio A. and Venti, Aaron and Yamaguchi, Osamu and Takagi, Shunsuke and Maeyama, Hiroki N. and Watanabe, Eizo and Yamaji, Yoshihiro and Shimizu, Kazuyoshi and Shiozaki, Kyoko and Futami, Satoru and Ryosuke, Sekine and Saito, Koji and Kameyama, Yoshinobu and Ueno, Keiko and Izawa, Masayo. and Okuda, Nao and Suzuki, Hiroyuki and Harasawa, Tomofumi and Nasu, Michitaka and Takada, Tadaaki and Ito, Fumihito and Nunomiya, Shin and Koyama, Kansuke and Abe, Toshikazu and Andoh, Kohkichi and Kusumoto, Kohei and Hirata, Akira and Takaba, Akihiro and Kimura, Hiroyasu and Matsumoto, Shuhei and Higashijima, Ushio and Honda, Hiroyuki and Aoki, Nobumasa and Imai, Hiroshi and Ogino, Yasuaki and Mizuguchi, Ichiko and Ichikado, Kazuya and Nitta, Kenichi and Mochizuki, Katsunori and Hashida, Tomoaki and Tanaka, Hiroyuki and Nakamura, Tomoyuki and Niimi, Daisuke and Ueda, Takeshi and Kashiwa, Yozo and Uchiyama, Akinori and Sabelnikovs, Olegs and Oss, Peteris and Haddad, Youssef and Liew, Kong Y. and Ñamendys-Silva, Silvio A. and Jarquin-Badiola, Yves D. and Sanchez-Hurtado, Luis A. and Gomez-Flores, Saira S. and Marin, Maria C. and Villagomez, Asisclo J. and Lemus, Jordana S. and Fierro, Jonathan M. and Cervantes, Mavy Ramirez and Mejia, Francisco Javier Flores and Dector, Dulce and Rojas, Alejandro and Gonzalez, Daniel R. and Estrella, Claudia R. and Sanchez-Medina, Jorge R. and Ramirez-Gutierrez, Alvaro and George, Fernando G. and Aguirre, Janet S. and Buensuseso, Juan A. and Poblano, Manuel and Dendane, Tarek and Zeggwagh, Amine Ali and Balkhi, Hicham and Elkhayari, Mina and Samkaoui, Nacer and Ezzouine, Hanane and Benslama, Abdellatif and Amor, Mourad and Maazouzi, Wajdi and Cimic, Nedim and Beck, Oliver and Bruns, Monique M. and Schouten, Jeroen A. and Rinia, Myra and Raaijmakers, Monique and Heunks, Leo M. and Van Wezel, Hellen M. and Heines, Serge J. and Strauch, Ulrich and Buise, Marc P. and Simonis, Fabienne D. and Goodson, Jennifer C. and Browne, Troy S. and Navarra, Leanlove and Hunt, Anna and Hutchison, Robyn A. and Bailey, Mathew B. and Newby, Lynette and McArthur, Colin and Kalkoff, Michael and Mcleod, Alex and Casement, Jonathan and Hacking, Danielle J. and Andersen, Finn H. and Dolva, Merete S. and Laake, Jon H. and Barratt-Due, Andreas and Noremark, Kim Andre L. and Søreide, Eldar and Sjøbø, Brit Å. and Guttormsen, Anne B. and Leon Yoshido, Hector H. and Aguilar, Ronald Zumaran and Montes Oscanoa, Fredy A. and Alisasis, Alain U. and Robles, Joanne B. and Pasanting-Lim, Rossini Abbie B. and Tan, Beatriz C. and Andruszkiewicz, Pawel and Jakubowska, Karina and Coxo, Cristina M. and Alvarez, António M. and Oliveira, Bruno S. and Montanha, Gustavo M. and Barros, Nelson C. and Pereira, Carlos S. and Messias, António M. and Monteiro, Jorge M. and Araujo, Ana M. and Catorze, Nuno T. and Marum, Susan M. and Bouw, Maria J. and Gomes, Rui M. and Brito, Vania A. and Castro, Silvia and Estilita, Joana M. and Barros, Filipa M. and Serra, Isabel M. and Martinho, Aurelia M. and Tomescu, Dana R. and Marcu, Alexandra and Bedreag, Ovidiu H. and Papurica, Marius and Corneci, Dan E. and Negoita, Silvius Ioan and Grigoriev, Evgeny and Gritsan, Alexey I. and Gazenkampf, Andrey A. and Almekhlafi, Ghaleb and Albarrak, Mohamad M. and Mustafa, Ghanem M. and Maghrabi, Khalid A. and Salahuddin, Nawal and Aisa, Tharwat M. and Al Jabbary, Ahmed S. and Tabhan, Edgardo and Arabi, Yaseen M. and Arabi, Yaseen M. and Trinidad, Olivia A. and Al Dorzi, Hasan M. and Tabhan, Edgardo E. and Bolon, Stefan and Smith, Oliver and Mancebo, Jordi and Aguirre-Bermeo, Hernan and Lopez-Delgado, Juan C. and Esteve, Francisco and Rialp, Gemma and Forteza, Catalina and Albaiceta, Guillermo M. and De Cima-Iglesias, Sara and Seoane-Quiroga, Leticia and Ceniceros-Barros, Alexandra and Ruiz-Aguilar, Antonio L. and Claraco-Vega, Luis M. and Soler, Juan Alfonso and del Carmen Lorente, Maria and Hermosa, Cecilia and Gordo, Federico and Prieto-González, Miryam and López-Messa, Juan B. and Perez, Manuel P. and Perez, Cesar P. and Montoiro Allue, Raquel and Roche-Campo, Ferran and Ibañez-Santacruz, Marcos and Temprano, Susana and Pintado, Maria C. and De Pablo, Raul and Aroa Gómez, Pilar Ricart and Ruiz, Silvia Rodriguez and Moles, Silvia Iglesias and Arizmendi, Alfons and Piacentini, Enrique A. and Franco, Nieves and Honrubia, Teresa and Cheng, Meisy Perez and Losada, Elena Perez and Blanco, Javier and Yuste, Luis J. and Carbayo-Gorriz, Cecilia and Cazorla-Barranquero, Francisca G. and Alonso, Javier G. and Alda, Rosa S. and Algaba, Ángela and Navarro, Gonzalo and Cereijo, Enrique and Diaz-Rodriguez, Esther and Pastor Marcos, Diego and Montero, Laura Alvarez and Para, Luis Herrera and Sanchez, Roberto Jimenez and Blasco Navalpotro, Miguel Angel and Abad, Ricardo Diaz and González, Raquel Montiel and Toribio, Dácil Parrilla and Castro, Alejandro G. and Artiga, Maria Jose D. and Penuelas, Oscar and Roser, Tomas P. and Olga, Moreno F. and Curto, Elena Gallego and Sánchez, Rocío Manzano and Imma, Vallverdu P. and Elisabet, Garcia M. and Claverias, Laura and Magret, Monica and Pellicer, Ana M. and Rodriguez, Lucia L. and Sánchez-Ballesteros, Jesús and González-Salamanca, Ángela and Jimenez, Antonio G. and Huerta, Francisco P. and Sotillo Diaz, Juan Carlos J. and Lopez, Esther Bermejo and Llinares Moya, David D. and Tallet Alfonso, Alec A. and Eugenio Luis, Palazon Sanchez and Cesar, Palazon Sanchez and Rafael, Sánchez I. and Virgilio, Corcoles G. and Recio, Noelia N. and Adamsson, Richard O. and Rylander, Christian C. and Holzgraefe, Bernhard and Broman, Lars M. and Wessbergh, Joanna and Persson, Linnea and Schiöler, Fredrik and Kedelv, Hans and Tibblin, Anna Oscarsson and Appelberg, Henrik and Hedlund, Lars and Helleberg, Johan and Eriksson, Karin E. and Glietsch, Rita and Larsson, Niklas and Nygren, Ingela and Nunes, Silvia L. and Morin, Anna-Karin and Kander, Thomas and Adolfsson, Anne and Piquilloud, Lise and Zender, Hervé O. and Leemann-Refondini, Corinne and Elatrous, Souheil and Bouchoucha, Slaheddine and Chouchene, Imed and Ouanes, Islem and Souissi, Asma Ben and Kamoun, Salma and Demirkiran, Oktay and Aker, Mustafa and Erbabacan, Emre and Ceylan, Ilkay and Girgin, Nermin Kelebek and Ozcelik, Menekse and Ünal, Necmettin and Meco, Basak Ceyda and Akyol, Onat O. and Derman, Suleyman S. and Kennedy, Barry and Parhar, Ken and Srinivasa, Latha and McNamee, Lia and McAuley, Danny and Hopkins, Phil and Mellis, Clare and Kakar, Vivek and Hadfield, Dan and Vercueil, Andre and Bhowmick, Kaushik and Humphreys, Sally K. and Ferguson, Andrew and Mckee, Raymond and Raj, Ashok S. and Fawkes, Danielle A. and Watt, Philip and Twohey, Linda and Jha, Rajeev R. and Thomas, Matthew and Morton, Alex and Kadaba, Varsha and Smith, Mark J. and Hormis, Anil P. and Kannan, Santhana G. and Namih, Miriam and Reschreiter, Henrik and Camsooksai, Julie and Kumar, Alek and Rugonfalvi, Szabolcs and Nutt, Christopher and Oneill, Orla and Seasman, Colette and Dempsey, Ged and Scott, Christopher J. and Ellis, Helen E. and Mckechnie, Stuart and Hutton, Paula J. and Di Tomasso, Nora N. and Vitale, Michela N. and Griffin, Ruth O. and Dean, Michael N. and Cranshaw, Julius H. and Willett, Emma L. and Ioannou, Nicholas and Gillis, Sarah and Csabi, Peter and Macfadyen, Rosaleen and Dawson, Heidi and Preez, Pieter D. and Williams, Alexandra J. and Boyd, Owen and Ortiz-Ruiz de Gordoa, Laura and Bramall, Jon and Symmonds, Sophie and Chau, Simon K. and Wenham, Tim and Szakmany, Tamas and Toth-Tarsoly, Piroska and Mccalman, Katie H. and Alexander, Peter and Stephenson, Lorraine and Collyer, Thomas and Chapman, Rhiannon and Cooper, Raphael and Allan, Russell M. and Sim, Malcolm and Wrathall, David W. and Irvine, Donald A. and Zantua, Kim S. and Adams, John C. and Burtenshaw, Andrew J. and Sellors, Gareth P. and Welters, Ingeborg D. and Williams, Karen E. and Hessell, Robert J. and Oldroyd, Matthew G. and Battle, Ceri E. and Pillai, Suresh and Kajtor, Istvan and Sivashanmugavel, Mageswaran and Okane, Sinead C. and Donnelly, Adrian and Frigyik, Aniko D. and Careless, Jon P. and May, Martin M. and Stewart, Richard and Trinder, T. John and Hagan, Samantha J. and Cole, Jade M. and MacFie, Caroline C. and Dowling, Anna T. and Hurtado, Javier and Nin, Nicolás and Hurtado, Javier and Nuñez, Edgardo and Pittini, Gustavo and Rodriguez, Ruben and Imperio, María C. and Santos, Cristina and França, Ana G. and Ebeid, Alejandro and Deicas, Alberto and Serra, Carolina and Uppalapati, Aditya and Kamel, Ghassan and Banner-Goodspeed, Valerie M. and Beitler, Jeremy R. and Mukkera, Satyanarayana Reddy and Kulkarni, Shreedhar and Lee, Jarone and Mesar, Tomaz and Shinn, John O. and Gomaa, Dina and Tainter, Christopher and Lee, Jarone and Mesar, Tomaz and Lee, Jarone and Yeatts, Dale J. and Lanspa, Michael J. and Miller, Russel R. and Grissom, Colin K. and Brown, Samuel M. and Bauer, Philippe R. and Gosselin, Ryan J. and Kitch, Barrett T. and Cohen, Jason E. and Beegle, Scott H. and Choudry, Shazia and Gueret, Renaud M. and Tulaimat, Aiman and Stigler, William and Batra, Hitesh and Huff, Nidhi G. and Lamb, Keith D. and Oetting, Trevor W. and Mohr, Nicholas M. and Judy, Claine and Saito, Shigeki and Kheir, Fayez M. and Kheir, Fayez and Schlichting, Adam B. and Delsing, Angela and Crouch, Daniel R. and Elmasri, Mary and Crouch, Daniel R. and Ismail, Dina and Dreyer, Kyle R. and Blakeman, Thomas C. and Gomaa, Dina and Baron, Rebecca M. and Grijalba, Carolina Quintana and Hou, Peter C. and Seethala, Raghu and Aisiku, Imo and Henderson, Galen and Frendl, Gyorgy and Hou, Sen-Kuang and Owens, Robert L. and Schomer, Ashley and Bumbasirevic, Vesna and Jovanovic, Bojan and Surbatovic, Maja and Veljovic, Milic}},
  issn         = {{0003-3022}},
  journal      = {{ANESTHESIOLOGY}},
  keywords     = {{END-EXPIRATORY PRESSURE,INTENSIVE-CARE UNITS,MECHANICAL VENTILATION,HOSPITAL MORTALITY,SOFA SCORE,INJURY,ARDS,EPIDEMIOLOGY,SUBPHENOTYPES,DEFINITIONS}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{263--283}},
  title        = {{Outcomes of patients presenting with mild acute respiratory distress syndrome : insights from the LUNG SAFE study}},
  url          = {{http://doi.org/10.1097/aln.0000000000002508}},
  volume       = {{130}},
  year         = {{2019}},
}

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