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The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

Pei Y Liu, Andrew E Tee, Giorgio Milazzo, Katherine M Hannan, Jesper Maag, Sujanna Mondal, Bernard Atmadibrata, Nenad Bartonicek, Hui Peng, Nicholas Ho, et al.
(2019) NATURE COMMUNICATIONS. 10.
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Abstract
The majority of patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein over-expression die of the disease. Here our analyses of RNA sequencing data identify the long noncoding RNA lncNB1 as one of the transcripts most overexpressed in MYCN-amplified, compared with MYCN-non-amplified, human neuroblastoma cells and also the most over-expressed in neuroblastoma compared with all other cancers. lncNB1 binds to the ribosomal protein RPL35 to enhance E2F1 protein synthesis, leading to DEPDC1B gene transcription. The GTPase-activating protein DEPDC1B induces ERK protein phosphorylation and N-Myc protein stabilization. Importantly, lncNB1 knockdown abolishes neuroblastoma cell clonogenic capacity in vitro and leads to neuroblastoma tumor regression in mice, while high levels of lncNB1 and RPL35 in human neuroblastoma tissues predict poor patient prognosis. This study therefore identifies lncNB1 and its binding protein RPL35 as key factors for promoting E2F1 protein synthesis, N-Myc protein stability and N-Myc-driven oncogenesis, and as therapeutic targets.
Keywords
GENE-EXPRESSION, BIOCONDUCTOR PACKAGE, MYC, NEUROBLASTOMA, CHROMATIN, TARGET

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MLA
Liu, Pei Y., et al. “The Long Noncoding RNA LncNB1 Promotes Tumorigenesis by Interacting with Ribosomal Protein RPL35.” NATURE COMMUNICATIONS, vol. 10, 2019, doi:10.1038/s41467-019-12971-3.
APA
Liu, P. Y., Tee, A. E., Milazzo, G., Hannan, K. M., Maag, J., Mondal, S., … Liu, T. (2019). The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35. NATURE COMMUNICATIONS, 10. https://doi.org/10.1038/s41467-019-12971-3
Chicago author-date
Liu, Pei Y, Andrew E Tee, Giorgio Milazzo, Katherine M Hannan, Jesper Maag, Sujanna Mondal, Bernard Atmadibrata, et al. 2019. “The Long Noncoding RNA LncNB1 Promotes Tumorigenesis by Interacting with Ribosomal Protein RPL35.” NATURE COMMUNICATIONS 10. https://doi.org/10.1038/s41467-019-12971-3.
Chicago author-date (all authors)
Liu, Pei Y, Andrew E Tee, Giorgio Milazzo, Katherine M Hannan, Jesper Maag, Sujanna Mondal, Bernard Atmadibrata, Nenad Bartonicek, Hui Peng, Nicholas Ho, Chelsea Mayoh, Roberto Ciaccio, Yuting Sun, Michelle J Henderson, Jixuan Gao, Celine Everaert, Amy J Hulme, Matthew Wong, Qing Lan, Belamy B Cheung, Leming Shi, Jenny Y Wang, Thorsten Simon, Matthias Fischer, Xu D Zhang, Glenn M Marshall, Murray D Norris, Michelle Haber, Jo Vandesompele, Jinyan Li, Pieter Mestdagh, Ross D Hannan, Marcel E Dinger, Giovanni Perini, and Tao Liu. 2019. “The Long Noncoding RNA LncNB1 Promotes Tumorigenesis by Interacting with Ribosomal Protein RPL35.” NATURE COMMUNICATIONS 10. doi:10.1038/s41467-019-12971-3.
Vancouver
1.
Liu PY, Tee AE, Milazzo G, Hannan KM, Maag J, Mondal S, et al. The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35. NATURE COMMUNICATIONS. 2019;10.
IEEE
[1]
P. Y. Liu et al., “The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35,” NATURE COMMUNICATIONS, vol. 10, 2019.
@article{8636036,
  abstract     = {{The majority of patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein over-expression die of the disease. Here our analyses of RNA sequencing data identify the long noncoding RNA lncNB1 as one of the transcripts most overexpressed in MYCN-amplified, compared with MYCN-non-amplified, human neuroblastoma cells and also the most over-expressed in neuroblastoma compared with all other cancers. lncNB1 binds to the ribosomal protein RPL35 to enhance E2F1 protein synthesis, leading to DEPDC1B gene transcription. The GTPase-activating protein DEPDC1B induces ERK protein phosphorylation and N-Myc protein stabilization. Importantly, lncNB1 knockdown abolishes neuroblastoma cell clonogenic capacity in vitro and leads to neuroblastoma tumor regression in mice, while high levels of lncNB1 and RPL35 in human neuroblastoma tissues predict poor patient prognosis. This study therefore identifies lncNB1 and its binding protein RPL35 as key factors for promoting E2F1 protein synthesis, N-Myc protein stability and N-Myc-driven oncogenesis, and as therapeutic targets.}},
  articleno    = {{5026}},
  author       = {{Liu, Pei Y and Tee, Andrew E and Milazzo, Giorgio and Hannan, Katherine M and Maag, Jesper and Mondal, Sujanna and Atmadibrata, Bernard and Bartonicek, Nenad and Peng, Hui and Ho, Nicholas and Mayoh, Chelsea and Ciaccio, Roberto and Sun, Yuting and Henderson, Michelle J and Gao, Jixuan and Everaert, Celine and Hulme, Amy J and Wong, Matthew and Lan, Qing and Cheung, Belamy B and Shi, Leming and Wang, Jenny Y and Simon, Thorsten and Fischer, Matthias and Zhang, Xu D and Marshall, Glenn M and Norris, Murray D and Haber, Michelle and Vandesompele, Jo and Li, Jinyan and Mestdagh, Pieter and Hannan, Ross D and Dinger, Marcel E and Perini, Giovanni and Liu, Tao}},
  issn         = {{2041-1723}},
  journal      = {{NATURE COMMUNICATIONS}},
  keywords     = {{GENE-EXPRESSION,BIOCONDUCTOR PACKAGE,MYC,NEUROBLASTOMA,CHROMATIN,TARGET}},
  language     = {{eng}},
  pages        = {{17}},
  title        = {{The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35}},
  url          = {{http://doi.org/10.1038/s41467-019-12971-3}},
  volume       = {{10}},
  year         = {{2019}},
}
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