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Near-infrared fluorescence guided esophageal reconstructive surgery: A systematic review

Elke Van Daele (UGent) , Yves Van Nieuwenhove (UGent) , Wim Ceelen (UGent) , Christian Vanhove (UGent) , Bart Braeckman (UGent) , Anne Hoorens (UGent) , Jurgen Van Limmen (UGent) , Oswald Varin (UGent) , Dirk Van de Putte (UGent) , Wouter Willaert (UGent) , et al.
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Abstract
BACKGROUND After an esophagectomy, the stomach is most commonly used to restore continuity of the upper gastrointestinal tract. These esophago-gastric anastomoses are prone to serious complications such as leakage associated with high morbidity and mortality. Graft perfusion is considered to be an important predictor for anastomotic integrity. Based on the current literature we believe Indocyanine green fluorescence angiography (ICGA) is an easy assessment tool for gastric tube (GT) perfusion, and it might predict anastomotic leakage (AL). AIM To evaluate feasibility and effectiveness of ICGA in GT perfusion assessment and as a predictor of AL. METHODS This study was designed according to the PRISMA guidelines and registered in the PROSPERO database. PubMed and EMBASE were independently searched by 2 reviewers for studies presenting data on intraoperative ICGA GT perfusion assessment during esophago-gastric reconstruction after esophagectomy. Relevant outcomes such as feasibility, complications, intraoperative surgical changes based on ICGA findings, quantification attempts, anatomical data and the impact of ICGA on postoperative anastomotic complications, were collected by 2 independent researchers. The quality of the included articles was assessed based on the Methodological Index for Non-Randomized Studies. The 19 included studies presented data on 1192 esophagectomy patients, in 758 patients ICGA was used perioperative to guide esophageal reconstruction. RESULTS The 19 included studies for qualitative analyses all described ICGA as a safe and easy method to evaluate gastric graft perfusion. AL occurred in 13.8% of the entire cohort, 10% in the ICG guided group and 20.6% in the control group (P < 0.001). When poorly perfused cases are excluded from the analyses, the difference in AL was even larger (AL well-perfused group 6.3% vs control group 20.5%, P < 0.001). The AL rate in the group with an altered surgical plan based on the ICG image was 6.5%, similar to the well perfused group (6.3%) and significantly less than the poorly perfused group (47.8%) (P < 0.001), suggesting that the technique is able to identify and alter a potential bad outcome. CONCLUSION ICGA is a safe, feasible and promising method for perfusion assessment. The lower AL rate in the well perfused group suggest that a good fluorescent signal predicts a good outcome.
Keywords
GASTRIC CONDUIT PERFUSION, GREEN TISSUE ANGIOGRAPHY, INDOCYANINE GREEN, ANASTOMOTIC LEAK, BLOOD-FLOW, ENHANCED REALITY, TUBE PERFUSION, CANCER, SITE, COMPLICATIONS, Indocyanine green, Angiography, Fluorescence, Esophagectomy, Anastomotic, leak, Near-infrared spectroscopy, Esophageal neoplasms, Esophageal, cancer

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MLA
Van Daele, Elke, et al. “Near-Infrared Fluorescence Guided Esophageal Reconstructive Surgery: A Systematic Review.” WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, vol. 11, no. 3, Baishideng Publishing Group Inc, 2019, pp. 250–63.
APA
Van Daele, E., Van Nieuwenhove, Y., Ceelen, W., Vanhove, C., Braeckman, B., Hoorens, A., … Pattyn, P. (2019). Near-infrared fluorescence guided esophageal reconstructive surgery: A systematic review. WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 11(3), 250–263.
Chicago author-date
Van Daele, Elke, Yves Van Nieuwenhove, Wim Ceelen, Christian Vanhove, Bart Braeckman, Anne Hoorens, Jurgen Van Limmen, et al. 2019. “Near-Infrared Fluorescence Guided Esophageal Reconstructive Surgery: A Systematic Review.” WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY 11 (3): 250–63.
Chicago author-date (all authors)
Van Daele, Elke, Yves Van Nieuwenhove, Wim Ceelen, Christian Vanhove, Bart Braeckman, Anne Hoorens, Jurgen Van Limmen, Oswald Varin, Dirk Van de Putte, Wouter Willaert, and Piet Pattyn. 2019. “Near-Infrared Fluorescence Guided Esophageal Reconstructive Surgery: A Systematic Review.” WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY 11 (3): 250–263.
Vancouver
1.
Van Daele E, Van Nieuwenhove Y, Ceelen W, Vanhove C, Braeckman B, Hoorens A, et al. Near-infrared fluorescence guided esophageal reconstructive surgery: A systematic review. WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY. 2019;11(3):250–63.
IEEE
[1]
E. Van Daele et al., “Near-infrared fluorescence guided esophageal reconstructive surgery: A systematic review,” WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, vol. 11, no. 3, pp. 250–263, 2019.
@article{8634866,
  abstract     = {BACKGROUND After an esophagectomy, the stomach is most commonly used to restore continuity of the upper gastrointestinal tract. These esophago-gastric anastomoses are prone to serious complications such as leakage associated with high morbidity and mortality. Graft perfusion is considered to be an important predictor for anastomotic integrity. Based on the current literature we believe Indocyanine green fluorescence angiography (ICGA) is an easy assessment tool for gastric tube (GT) perfusion, and it might predict anastomotic leakage (AL). AIM To evaluate feasibility and effectiveness of ICGA in GT perfusion assessment and as a predictor of AL. METHODS This study was designed according to the PRISMA guidelines and registered in the PROSPERO database. PubMed and EMBASE were independently searched by 2 reviewers for studies presenting data on intraoperative ICGA GT perfusion assessment during esophago-gastric reconstruction after esophagectomy. Relevant outcomes such as feasibility, complications, intraoperative surgical changes based on ICGA findings, quantification attempts, anatomical data and the impact of ICGA on postoperative anastomotic complications, were collected by 2 independent researchers. The quality of the included articles was assessed based on the Methodological Index for Non-Randomized Studies. The 19 included studies presented data on 1192 esophagectomy patients, in 758 patients ICGA was used perioperative to guide esophageal reconstruction. RESULTS The 19 included studies for qualitative analyses all described ICGA as a safe and easy method to evaluate gastric graft perfusion. AL occurred in 13.8% of the entire cohort, 10% in the ICG guided group and 20.6% in the control group (P < 0.001). When poorly perfused cases are excluded from the analyses, the difference in AL was even larger (AL well-perfused group 6.3% vs control group 20.5%, P < 0.001). The AL rate in the group with an altered surgical plan based on the ICG image was 6.5%, similar to the well perfused group (6.3%) and significantly less than the poorly perfused group (47.8%) (P < 0.001), suggesting that the technique is able to identify and alter a potential bad outcome. CONCLUSION ICGA is a safe, feasible and promising method for perfusion assessment. The lower AL rate in the well perfused group suggest that a good fluorescent signal predicts a good outcome.},
  author       = {Van Daele, Elke and Van Nieuwenhove, Yves and Ceelen, Wim and Vanhove, Christian and Braeckman, Bart and Hoorens, Anne and Van Limmen, Jurgen and Varin, Oswald and Van de Putte, Dirk and Willaert, Wouter and Pattyn, Piet},
  issn         = {1948-5204},
  journal      = {WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY},
  keywords     = {GASTRIC CONDUIT PERFUSION,GREEN TISSUE ANGIOGRAPHY,INDOCYANINE GREEN,ANASTOMOTIC LEAK,BLOOD-FLOW,ENHANCED REALITY,TUBE PERFUSION,CANCER,SITE,COMPLICATIONS,Indocyanine green,Angiography,Fluorescence,Esophagectomy,Anastomotic,leak,Near-infrared spectroscopy,Esophageal neoplasms,Esophageal,cancer},
  language     = {eng},
  number       = {3},
  pages        = {250--263},
  publisher    = {Baishideng Publishing Group Inc},
  title        = {Near-infrared fluorescence guided esophageal reconstructive surgery: A systematic review},
  url          = {http://dx.doi.org/10.4251/wjgo.v11.i3.250},
  volume       = {11},
  year         = {2019},
}

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