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Baseline functional connectivity may predict placebo responses to accelerated rTMS treatment in major depression

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Abstract
Although in theory sham repetitive transcranial magnetic stimulation (rTMS) has no inherent therapeutic value, nonetheless, such placebo stimulations may have relevant therapeutic effects in clinically depressed patients. On the other hand, antidepressant responses to sham rTMS are quite heterogeneous across individuals and its neural underpinnings have not been explored yet. The current brain imaging study aims to detect baseline neural fingerprints resulting in clinically beneficial placebo rTMS treatment responses. We collected resting-state functional magnetic resonance imaging data prior to a registered randomized clinical trial of accelerated placebo stimulation protocol in patients documented with treatment-resistant depression (). In addition to global brain connectivity and rostral anterior cingulate cortex (rACC) seed-based functional connectivity (FC), elastic-net regression and cross-validation procedures were used to identify baseline intrinsic brain connectivity biomarkers for sham-rTMS responses. Placebo responses to accelerated sham rTMS were correlated with baseline global brain connectivity in the rACC/ventral medial prefrontal cortex (vmPFC). Concerning the rACC seed-based FC analysis, the placebo response was associated positively with the precuneus/posterior cingulate (PCun/PCC) cortex and negatively with the middle frontal gyrus. Our findings provide first brain imaging evidence for placebo responses to sham stimulation being predictable from rACC rsFC profiles, especially in brain areas implicated in (re)appraisal and self-focus processes.
Keywords
depression, functional connectivity, placebo responses, rostral ACC, sham iTBS, sham rTMS, TRANSCRANIAL MAGNETIC STIMULATION, THETA-BURST STIMULATION, DEFAULT MODE NETWORK, MECHANISMS, DISORDER, SELF, PSYCHOPATHOLOGY, PSYCHOTHERAPY, METAANALYSIS, DYSFUNCTION

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Citation

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MLA
Wu, Guo‐Rong, et al. “Baseline Functional Connectivity May Predict Placebo Responses to Accelerated RTMS Treatment in Major Depression.” HUMAN BRAIN MAPPING, 2020, doi:10.1002/hbm.24828.
APA
Wu, G., Wang, X., & Baeken, C. (2020). Baseline functional connectivity may predict placebo responses to accelerated rTMS treatment in major depression. HUMAN BRAIN MAPPING. https://doi.org/10.1002/hbm.24828
Chicago author-date
Wu, Guo‐Rong, Xiaowan Wang, and Chris Baeken. 2020. “Baseline Functional Connectivity May Predict Placebo Responses to Accelerated RTMS Treatment in Major Depression.” HUMAN BRAIN MAPPING. https://doi.org/10.1002/hbm.24828.
Chicago author-date (all authors)
Wu, Guo‐Rong, Xiaowan Wang, and Chris Baeken. 2020. “Baseline Functional Connectivity May Predict Placebo Responses to Accelerated RTMS Treatment in Major Depression.” HUMAN BRAIN MAPPING. doi:10.1002/hbm.24828.
Vancouver
1.
Wu G, Wang X, Baeken C. Baseline functional connectivity may predict placebo responses to accelerated rTMS treatment in major depression. HUMAN BRAIN MAPPING. 2020;
IEEE
[1]
G. Wu, X. Wang, and C. Baeken, “Baseline functional connectivity may predict placebo responses to accelerated rTMS treatment in major depression,” HUMAN BRAIN MAPPING, 2020.
@article{8634677,
  abstract     = {Although in theory sham repetitive transcranial magnetic stimulation (rTMS) has no inherent therapeutic value, nonetheless, such placebo stimulations may have relevant therapeutic effects in clinically depressed patients. On the other hand, antidepressant responses to sham rTMS are quite heterogeneous across individuals and its neural underpinnings have not been explored yet. The current brain imaging study aims to detect baseline neural fingerprints resulting in clinically beneficial placebo rTMS treatment responses. We collected resting-state functional magnetic resonance imaging data prior to a registered randomized clinical trial of accelerated placebo stimulation protocol in patients documented with treatment-resistant depression (). In addition to global brain connectivity and rostral anterior cingulate cortex (rACC) seed-based functional connectivity (FC), elastic-net regression and cross-validation procedures were used to identify baseline intrinsic brain connectivity biomarkers for sham-rTMS responses. Placebo responses to accelerated sham rTMS were correlated with baseline global brain connectivity in the rACC/ventral medial prefrontal cortex (vmPFC). Concerning the rACC seed-based FC analysis, the placebo response was associated positively with the precuneus/posterior cingulate (PCun/PCC) cortex and negatively with the middle frontal gyrus. Our findings provide first brain imaging evidence for placebo responses to sham stimulation being predictable from rACC rsFC profiles, especially in brain areas implicated in (re)appraisal and self-focus processes.},
  author       = {Wu, Guo‐Rong and Wang, Xiaowan and Baeken, Chris},
  issn         = {1065-9471},
  journal      = {HUMAN BRAIN MAPPING},
  keywords     = {depression,functional connectivity,placebo responses,rostral ACC,sham iTBS,sham rTMS,TRANSCRANIAL MAGNETIC STIMULATION,THETA-BURST STIMULATION,DEFAULT MODE NETWORK,MECHANISMS,DISORDER,SELF,PSYCHOPATHOLOGY,PSYCHOTHERAPY,METAANALYSIS,DYSFUNCTION},
  language     = {eng},
  title        = {Baseline functional connectivity may predict placebo responses to accelerated rTMS treatment in major depression},
  url          = {http://dx.doi.org/10.1002/hbm.24828},
  year         = {2020},
}

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