Advanced search
1 file | 280.39 KB Add to list

Cost-utility analysis of lifestyle interventions to prevent type 2 diabetes in women with prior gestational diabetes

Author
Organization
Abstract
Background: To compare estimated costs and health outcomes of lifestyle interventions for the prevention of type 2 diabetes mellitus in women who had gestational diabetes. Methods: An age-specific Markov model was applied comparing costs and quality-adjusted life years (QALYs) of three alternatives: ‘doing nothing’; an annual reminder system (ARS) with an awareness campaign (‘ARS-awareness’); and an ARS with an intensive lifestyle intervention (‘ARS-ILS’). A healthcare payer perspective was adopted, the time horizon was 30 years and the setting was Flanders (Belgium). Sensitivity analyses were performed. Results: ‘ARS-awareness’ was extendedly dominated. Per 10 000 participants, ‘ARS-ILS’ cost €13 210 256 more and gained 496 QALYs compared with ‘doing nothing’ (26 632 €/QALY), with a 63% probability of being cost effective, given a cost effectiveness threshold of 35 000 €/QALY. A scenario analysis showed that ‘ARS-ILS’ for 15 years only offered to women with prediabetes (compared with ‘doing nothing’) has an 89.5% likelihood of being dominant. Conclusions: ‘ARS-ILS’ may be the preferred intervention. However, the probability of being cost effective was low. Based on further scenario analyses, we recommend healthcare decision makers to consider the application of a more intensive alternative, focused on the highest risk profiles and with a shorter intervention duration.
Keywords
diabetes mellitus, type 2, gestational diabetes, cost effectiveness, costs and benefits, belgium, life style, quality-adjusted life years, reminder systems, prediabetes, health outcomes, sensitivity analysis, healthcare payer, prevention, CARDIOVASCULAR MORTALITY, ALL-CAUSE, MELLITUS, PEOPLE, CARE

Downloads

  • (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 280.39 KB

Citation

Please use this url to cite or link to this publication:

MLA
Werbrouck, Amber, et al. “Cost-Utility Analysis of Lifestyle Interventions to Prevent Type 2 Diabetes in Women with Prior Gestational Diabetes.” EUROPEAN JOURNAL OF PUBLIC HEALTH, vol. 30, no. 3, 2020, pp. 396–401, doi:10.1093/eurpub/ckz196.
APA
Werbrouck, A., Schmidt, M., Putman, K., Annemans, L., Benhalima, K., Simoens, S., & Verhaeghe, N. (2020). Cost-utility analysis of lifestyle interventions to prevent type 2 diabetes in women with prior gestational diabetes. EUROPEAN JOURNAL OF PUBLIC HEALTH, 30(3), 396–401. https://doi.org/10.1093/eurpub/ckz196
Chicago author-date
Werbrouck, Amber, Masja Schmidt, Koen Putman, Lieven Annemans, Katrien Benhalima, Steven Simoens, and Nick Verhaeghe. 2020. “Cost-Utility Analysis of Lifestyle Interventions to Prevent Type 2 Diabetes in Women with Prior Gestational Diabetes.” EUROPEAN JOURNAL OF PUBLIC HEALTH 30 (3): 396–401. https://doi.org/10.1093/eurpub/ckz196.
Chicago author-date (all authors)
Werbrouck, Amber, Masja Schmidt, Koen Putman, Lieven Annemans, Katrien Benhalima, Steven Simoens, and Nick Verhaeghe. 2020. “Cost-Utility Analysis of Lifestyle Interventions to Prevent Type 2 Diabetes in Women with Prior Gestational Diabetes.” EUROPEAN JOURNAL OF PUBLIC HEALTH 30 (3): 396–401. doi:10.1093/eurpub/ckz196.
Vancouver
1.
Werbrouck A, Schmidt M, Putman K, Annemans L, Benhalima K, Simoens S, et al. Cost-utility analysis of lifestyle interventions to prevent type 2 diabetes in women with prior gestational diabetes. EUROPEAN JOURNAL OF PUBLIC HEALTH. 2020;30(3):396–401.
IEEE
[1]
A. Werbrouck et al., “Cost-utility analysis of lifestyle interventions to prevent type 2 diabetes in women with prior gestational diabetes,” EUROPEAN JOURNAL OF PUBLIC HEALTH, vol. 30, no. 3, pp. 396–401, 2020.
@article{8633962,
  abstract     = {Background: To compare estimated costs and health outcomes of lifestyle interventions for the prevention of type 2 diabetes mellitus in women who had gestational diabetes.

Methods: An age-specific Markov model was applied comparing costs and quality-adjusted life years (QALYs) of three alternatives: ‘doing nothing’; an annual reminder system (ARS) with an awareness campaign (‘ARS-awareness’); and an ARS with an intensive lifestyle intervention (‘ARS-ILS’). A healthcare payer perspective was adopted, the time horizon was 30 years and the setting was Flanders (Belgium). Sensitivity analyses were performed.

Results: ‘ARS-awareness’ was extendedly dominated. Per 10 000 participants, ‘ARS-ILS’ cost €13 210 256 more and gained 496 QALYs compared with ‘doing nothing’ (26 632 €/QALY), with a 63% probability of being cost effective, given a cost effectiveness threshold of 35 000 €/QALY. A scenario analysis showed that ‘ARS-ILS’ for 15 years only offered to women with prediabetes (compared with ‘doing nothing’) has an 89.5% likelihood of being dominant.

Conclusions: ‘ARS-ILS’ may be the preferred intervention. However, the probability of being cost effective was low. Based on further scenario analyses, we recommend healthcare decision makers to consider the application of a more intensive alternative, focused on the highest risk profiles and with a shorter intervention duration.},
  author       = {Werbrouck, Amber and Schmidt, Masja and Putman, Koen and Annemans, Lieven and Benhalima, Katrien and Simoens, Steven and Verhaeghe, Nick},
  issn         = {1101-1262},
  journal      = {EUROPEAN JOURNAL OF PUBLIC HEALTH},
  keywords     = {diabetes mellitus,type 2,gestational diabetes,cost effectiveness,costs and benefits,belgium,life style,quality-adjusted life years,reminder systems,prediabetes,health outcomes,sensitivity analysis,healthcare payer,prevention,CARDIOVASCULAR MORTALITY,ALL-CAUSE,MELLITUS,PEOPLE,CARE},
  language     = {eng},
  number       = {3},
  pages        = {396--401},
  title        = {Cost-utility analysis of lifestyle interventions to prevent type 2 diabetes in women with prior gestational diabetes},
  url          = {http://dx.doi.org/10.1093/eurpub/ckz196},
  volume       = {30},
  year         = {2020},
}

Altmetric
View in Altmetric
Web of Science
Times cited: