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The long-term effects of single and repeated subanaesthetic ketamine administration on regional cerebral blood flow in healthy dogs measured with 99mTc-HMPAO SPECT

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Abstract
Subanaesthetic ketamine has recently been established as an effective and rapid treatment for major depressive disorder showing antidepressant effects for up to 1 week on average. The use of repeated ketamine infusions has been put forward to augment and to prolong the antidepressant response and increase the remission rates. The underlying neurobiological mechanisms responsible for ketamine's antidepressant effects remain unclear. Nevertheless, it has been shown, both in dogs and humans, that ketamine can alter neuronal perfusion and therefore neuronal function in brain regions involved in psychiatric and behavioural disorders. Consequently, the aim of the current placebo controlled study was to assess the long-term effects on cerebral perfusion of single and repeated subanaesthetic ketamine infusions in dogs. Twelve healthy, laboratory dogs were scanned at six different time points following single and repeated ketamine administration, using Single Photon Emission Computed Tomography with the radiotracer Tc-99m-hexamethylpropylene amine oxime. We hypothesised that repeated infusions could lead to more prolonged perfusion alterations in brain regions critical for behaviour regulation. We found that repeated subanaesthetic ketamine administration did not result in more prolonged cerebral perfusion alterations compared to a single ketamine administration.
Keywords
Brain perfusion, Canine, Major depressive disorder, Psychiatry, Functional imaging, RESISTANT UNIPOLAR DEPRESSION, INTRAVENOUS KETAMINE, SUBANESTHETIC KETAMINE, SEPARATION ANXIETY, BRAIN PERFUSION, DOUBLE-BLIND, ANTIDEPRESSANT, RECEPTOR, PET, INFUSIONS

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MLA
Vlerick, Lise, et al. “The Long-Term Effects of Single and Repeated Subanaesthetic Ketamine Administration on Regional Cerebral Blood Flow in Healthy Dogs Measured with 99mTc-HMPAO SPECT.” PSYCHIATRY RESEARCH-NEUROIMAGING, vol. 285, 2019, pp. 18–24, doi:10.1016/j.pscychresns.2019.01.005.
APA
Vlerick, L., Peremans, K., Dockx, R., Audenaert, K., Baeken, C., Saunders, J., & Polis, I. (2019). The long-term effects of single and repeated subanaesthetic ketamine administration on regional cerebral blood flow in healthy dogs measured with 99mTc-HMPAO SPECT. PSYCHIATRY RESEARCH-NEUROIMAGING, 285, 18–24. https://doi.org/10.1016/j.pscychresns.2019.01.005
Chicago author-date
Vlerick, Lise, Kathelijne Peremans, Robrecht Dockx, Kurt Audenaert, Chris Baeken, Jimmy Saunders, and Ingeborgh Polis. 2019. “The Long-Term Effects of Single and Repeated Subanaesthetic Ketamine Administration on Regional Cerebral Blood Flow in Healthy Dogs Measured with 99mTc-HMPAO SPECT.” PSYCHIATRY RESEARCH-NEUROIMAGING 285: 18–24. https://doi.org/10.1016/j.pscychresns.2019.01.005.
Chicago author-date (all authors)
Vlerick, Lise, Kathelijne Peremans, Robrecht Dockx, Kurt Audenaert, Chris Baeken, Jimmy Saunders, and Ingeborgh Polis. 2019. “The Long-Term Effects of Single and Repeated Subanaesthetic Ketamine Administration on Regional Cerebral Blood Flow in Healthy Dogs Measured with 99mTc-HMPAO SPECT.” PSYCHIATRY RESEARCH-NEUROIMAGING 285: 18–24. doi:10.1016/j.pscychresns.2019.01.005.
Vancouver
1.
Vlerick L, Peremans K, Dockx R, Audenaert K, Baeken C, Saunders J, et al. The long-term effects of single and repeated subanaesthetic ketamine administration on regional cerebral blood flow in healthy dogs measured with 99mTc-HMPAO SPECT. PSYCHIATRY RESEARCH-NEUROIMAGING. 2019;285:18–24.
IEEE
[1]
L. Vlerick et al., “The long-term effects of single and repeated subanaesthetic ketamine administration on regional cerebral blood flow in healthy dogs measured with 99mTc-HMPAO SPECT,” PSYCHIATRY RESEARCH-NEUROIMAGING, vol. 285, pp. 18–24, 2019.
@article{8633710,
  abstract     = {{Subanaesthetic ketamine has recently been established as an effective and rapid treatment for major depressive disorder showing antidepressant effects for up to 1 week on average. The use of repeated ketamine infusions has been put forward to augment and to prolong the antidepressant response and increase the remission rates. The underlying neurobiological mechanisms responsible for ketamine's antidepressant effects remain unclear. Nevertheless, it has been shown, both in dogs and humans, that ketamine can alter neuronal perfusion and therefore neuronal function in brain regions involved in psychiatric and behavioural disorders. Consequently, the aim of the current placebo controlled study was to assess the long-term effects on cerebral perfusion of single and repeated subanaesthetic ketamine infusions in dogs. Twelve healthy, laboratory dogs were scanned at six different time points following single and repeated ketamine administration, using Single Photon Emission Computed Tomography with the radiotracer Tc-99m-hexamethylpropylene amine oxime. We hypothesised that repeated infusions could lead to more prolonged perfusion alterations in brain regions critical for behaviour regulation. We found that repeated subanaesthetic ketamine administration did not result in more prolonged cerebral perfusion alterations compared to a single ketamine administration.}},
  author       = {{Vlerick, Lise and Peremans, Kathelijne and Dockx, Robrecht and Audenaert, Kurt and Baeken, Chris and Saunders, Jimmy and Polis, Ingeborgh}},
  issn         = {{0925-4927}},
  journal      = {{PSYCHIATRY RESEARCH-NEUROIMAGING}},
  keywords     = {{Brain perfusion,Canine,Major depressive disorder,Psychiatry,Functional imaging,RESISTANT UNIPOLAR DEPRESSION,INTRAVENOUS KETAMINE,SUBANESTHETIC KETAMINE,SEPARATION ANXIETY,BRAIN PERFUSION,DOUBLE-BLIND,ANTIDEPRESSANT,RECEPTOR,PET,INFUSIONS}},
  language     = {{eng}},
  pages        = {{18--24}},
  title        = {{The long-term effects of single and repeated subanaesthetic ketamine administration on regional cerebral blood flow in healthy dogs measured with 99mTc-HMPAO SPECT}},
  url          = {{http://dx.doi.org/10.1016/j.pscychresns.2019.01.005}},
  volume       = {{285}},
  year         = {{2019}},
}

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