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Health-related quality of life in advanced non-small cell lung cancer : a methodological appraisal based on a systematic literature review

Lotte van der Weijst (UGent) , Yolande Lievens (UGent) , Wim Schrauwen (UGent) and Veerle Surmont (UGent)
Author
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Abstract
Background: The majority of lung cancer patients are diagnosed with advanced non-small cell lung cancer (NSCLC), the bulk of which receive palliative systemic treatment with the goal to provide effective symptom palliation and safeguard health-related quality of life (HRQoL). Advanced NSCLC trials with HRQoL endpoints face methodological constraints limiting interpretability. Objectives: We provide a comprehensive overview of recent clinical trials evaluating the impact of systemic therapies on HRQoL in advanced NSCLC, focusing on the methodological quality, with the ultimate goal to improve interpretation, comparison and reporting of HRQoL data. Methods: A systematic literature review was performed. Prospective studies published over the last decade evaluating the impact of systemic treatments on HRQoL in advanced NSCLC were included. Methodological quality of HRQoL reporting was assessed with the CONSORT-PRO extension. Results: Hundred-twelve manuscripts describing 85 trials met all criteria. No formal conclusion can be drawn regarding the impact on HRQoL of different treatments. We report an important variety in methodological quality in terms of definitions of HRQoL, missing data points, lack of standardization of analyzing and presenting HRQoL and no standard follow-up time. The quality of HRQoL data reporting varies substantially between studies but improves over time. Conclusion: This review shows that in the heterogeneous landscape of trials addressing HRQoL in advanced stage NSCLC. Methodology reporting remains generally poor. Adequate reporting of HRQoL outcome data is equally important to support clinical decision-making as to correctly inform health policy regarding direct approval and reimbursement of the new drugs and combinations that will come online.
Keywords
quality of life, review-systematic, lung cancer, methodological quality, NSCLC: RANDOMIZED PHASE-III, DOCETAXEL PLUS CISPLATIN, COMPREHENSIVE GERIATRIC ASSESSMENT, PATIENT-REPORTED OUTCOMES, COMPARING PACLITAXEL POLIGLUMEX, GEFITINIB MAINTENANCE THERAPY, PLATINUM-BASED CHEMOTHERAPY, TREATED JAPANESE PATIENTS, SINGLE-AGENT GEMCITABINE, ELDERLY-PATIENTS

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MLA
van der Weijst, Lotte, et al. “Health-Related Quality of Life in Advanced Non-Small Cell Lung Cancer : A Methodological Appraisal Based on a Systematic Literature Review.” FRONTIERS IN ONCOLOGY, vol. 9, 2019.
APA
van der Weijst, L., Lievens, Y., Schrauwen, W., & Surmont, V. (2019). Health-related quality of life in advanced non-small cell lung cancer : a methodological appraisal based on a systematic literature review. FRONTIERS IN ONCOLOGY, 9.
Chicago author-date
Weijst, Lotte van der, Yolande Lievens, Wim Schrauwen, and Veerle Surmont. 2019. “Health-Related Quality of Life in Advanced Non-Small Cell Lung Cancer : A Methodological Appraisal Based on a Systematic Literature Review.” FRONTIERS IN ONCOLOGY 9.
Chicago author-date (all authors)
van der Weijst, Lotte, Yolande Lievens, Wim Schrauwen, and Veerle Surmont. 2019. “Health-Related Quality of Life in Advanced Non-Small Cell Lung Cancer : A Methodological Appraisal Based on a Systematic Literature Review.” FRONTIERS IN ONCOLOGY 9.
Vancouver
1.
van der Weijst L, Lievens Y, Schrauwen W, Surmont V. Health-related quality of life in advanced non-small cell lung cancer : a methodological appraisal based on a systematic literature review. FRONTIERS IN ONCOLOGY. 2019;9.
IEEE
[1]
L. van der Weijst, Y. Lievens, W. Schrauwen, and V. Surmont, “Health-related quality of life in advanced non-small cell lung cancer : a methodological appraisal based on a systematic literature review,” FRONTIERS IN ONCOLOGY, vol. 9, 2019.
@article{8632986,
  abstract     = {Background: The majority of lung cancer patients are diagnosed with advanced non-small cell lung cancer (NSCLC), the bulk of which receive palliative systemic treatment with the goal to provide effective symptom palliation and safeguard health-related quality of life (HRQoL). Advanced NSCLC trials with HRQoL endpoints face methodological constraints limiting interpretability. 
Objectives: We provide a comprehensive overview of recent clinical trials evaluating the impact of systemic therapies on HRQoL in advanced NSCLC, focusing on the methodological quality, with the ultimate goal to improve interpretation, comparison and reporting of HRQoL data. 
Methods: A systematic literature review was performed. Prospective studies published over the last decade evaluating the impact of systemic treatments on HRQoL in advanced NSCLC were included. Methodological quality of HRQoL reporting was assessed with the CONSORT-PRO extension. 
Results: Hundred-twelve manuscripts describing 85 trials met all criteria. No formal conclusion can be drawn regarding the impact on HRQoL of different treatments. We report an important variety in methodological quality in terms of definitions of HRQoL, missing data points, lack of standardization of analyzing and presenting HRQoL and no standard follow-up time. The quality of HRQoL data reporting varies substantially between studies but improves over time. 
Conclusion: This review shows that in the heterogeneous landscape of trials addressing HRQoL in advanced stage NSCLC. Methodology reporting remains generally poor. Adequate reporting of HRQoL outcome data is equally important to support clinical decision-making as to correctly inform health policy regarding direct approval and reimbursement of the new drugs and combinations that will come online.},
  articleno    = {715},
  author       = {van der Weijst, Lotte and Lievens, Yolande and Schrauwen, Wim and Surmont, Veerle},
  issn         = {2234-943X},
  journal      = {FRONTIERS IN ONCOLOGY},
  keywords     = {quality of life,review-systematic,lung cancer,methodological quality,NSCLC: RANDOMIZED PHASE-III,DOCETAXEL PLUS CISPLATIN,COMPREHENSIVE GERIATRIC ASSESSMENT,PATIENT-REPORTED OUTCOMES,COMPARING PACLITAXEL POLIGLUMEX,GEFITINIB MAINTENANCE THERAPY,PLATINUM-BASED CHEMOTHERAPY,TREATED JAPANESE PATIENTS,SINGLE-AGENT GEMCITABINE,ELDERLY-PATIENTS},
  language     = {eng},
  pages        = {13},
  title        = {Health-related quality of life in advanced non-small cell lung cancer : a methodological appraisal based on a systematic literature review},
  url          = {http://dx.doi.org/10.3389/fonc.2019.00715},
  volume       = {9},
  year         = {2019},
}

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