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The impact of the prostaglandin D₂ receptor 2 and its downstream effects on the pathophysiology of asthma

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Abstract
Current research suggests that the prostaglandin D-2 (PGD(2)) receptor 2 (DP2) is a principal regulator in the pathophysiology of asthma, because it stimulates and amplifies the inflammatory response in this condition. The DP2 receptor can be activated by both allergic and nonallergic stimuli, leading to several pro-inflammatory events, including eosinophil activation and migration, release of the type 2 cytokines interleukin (IL)-4, IL-5 and IL-13 from T helper 2 (Th2) cells and innate lymphoid cells type 2 (ILCs), and increased airway smooth muscle mass via recruitment of mesenchymal progenitors to the airway smooth muscle bundle. Activation of the DP2 receptor pathway has potential downstream effects on asthma pathophysiology, including on airway epithelial cells, mucus hypersecretion, and airway remodelling, and consequently might impact asthma symptoms and exacerbations. Given the broad distribution of DP2 receptors on immune and structural cells involved in asthma, this receptor is being explored as a novel therapeutic target.
Keywords
asthma, eosinophil, prostaglandin D-2 receptor 2, T helper type 2 cell, type 2 innate lymphoid cell KeyWords Plus:INNATE LYMPHOID-CELLS, HUMAN TH2 CELLS, ORAL CRTH2 ANTAGONIST, FEVIPIPRANT QAW039, DOUBLE-BLIND, EOSINOPHILS, EXPRESSION, INFLAMMATION, EFFICACY, SAFETY

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Citation

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MLA
Brightling, Christopher E., et al. “The Impact of the Prostaglandin D₂ Receptor 2 and Its Downstream Effects on the Pathophysiology of Asthma.” ALLERGY, 2020.
APA
Brightling, C. E., Brusselle, G., & Altman, P. (2020). The impact of the prostaglandin D₂ receptor 2 and its downstream effects on the pathophysiology of asthma. ALLERGY.
Chicago author-date
Brightling, Christopher E, Guy Brusselle, and Pablo Altman. 2020. “The Impact of the Prostaglandin D₂ Receptor 2 and Its Downstream Effects on the Pathophysiology of Asthma.” ALLERGY.
Chicago author-date (all authors)
Brightling, Christopher E, Guy Brusselle, and Pablo Altman. 2020. “The Impact of the Prostaglandin D₂ Receptor 2 and Its Downstream Effects on the Pathophysiology of Asthma.” ALLERGY.
Vancouver
1.
Brightling CE, Brusselle G, Altman P. The impact of the prostaglandin D₂ receptor 2 and its downstream effects on the pathophysiology of asthma. ALLERGY. 2020;
IEEE
[1]
C. E. Brightling, G. Brusselle, and P. Altman, “The impact of the prostaglandin D₂ receptor 2 and its downstream effects on the pathophysiology of asthma,” ALLERGY, 2020.
@article{8632752,
  abstract     = {Current research suggests that the prostaglandin D-2 (PGD(2)) receptor 2 (DP2) is a principal regulator in the pathophysiology of asthma, because it stimulates and amplifies the inflammatory response in this condition. The DP2 receptor can be activated by both allergic and nonallergic stimuli, leading to several pro-inflammatory events, including eosinophil activation and migration, release of the type 2 cytokines interleukin (IL)-4, IL-5 and IL-13 from T helper 2 (Th2) cells and innate lymphoid cells type 2 (ILCs), and increased airway smooth muscle mass via recruitment of mesenchymal progenitors to the airway smooth muscle bundle. Activation of the DP2 receptor pathway has potential downstream effects on asthma pathophysiology, including on airway epithelial cells, mucus hypersecretion, and airway remodelling, and consequently might impact asthma symptoms and exacerbations. Given the broad distribution of DP2 receptors on immune and structural cells involved in asthma, this receptor is being explored as a novel therapeutic target.},
  author       = {Brightling, Christopher E and Brusselle, Guy and Altman, Pablo},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keywords     = {asthma,eosinophil,prostaglandin D-2 receptor 2,T helper type 2 cell,type 2 innate lymphoid cell  KeyWords Plus:INNATE LYMPHOID-CELLS,HUMAN TH2 CELLS,ORAL CRTH2 ANTAGONIST,FEVIPIPRANT QAW039,DOUBLE-BLIND,EOSINOPHILS,EXPRESSION,INFLAMMATION,EFFICACY,SAFETY},
  language     = {eng},
  title        = {The impact of the prostaglandin D₂ receptor 2 and its downstream effects on the pathophysiology of asthma},
  url          = {http://dx.doi.org/10.1111/all.14001},
  year         = {2020},
}

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