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Frontostriatal functional connectivity correlates with repetitive behaviour across autism spectrum disorder and obsessive-compulsive disorder

(2019) PSYCHOLOGICAL MEDICINE. 49(13). p.2247-2255
Author
Organization
Abstract
Background: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) are neurodevelopmental disorders with considerable overlap in terms of their defining symptoms of compulsivity/repetitive behaviour. Little is known about the extent to which ASD and OCD have common versus distinct neural correlates of compulsivity. Previous research points to potentially common dysfunction in frontostriatal connectivity, but direct comparisons in one study are lacking. Here, we assessed frontostriatal resting-state functional connectivity in youth with ASD or OCD, and healthy controls. In addition, we applied a cross-disorder approach to examine whether repetitive behaviour across ASD and OCD has common neural substrates. Methods: A sample of 78 children and adolescents aged 8-16 years was used (ASD n = 24; OCD n = 25; healthy controls n = 29), originating from the multicentre study COMPULS. We tested whether diagnostic group, repetitive behaviour (measured with the Repetitive Behavior Scale-Revised) or their interaction was associated with resting-state functional connectivity of striatal seed regions. Results: No diagnosis-specific differences were detected. The cross-disorder analysis, on the other hand, showed that increased functional connectivity between the left nucleus accumbens (NAcc) and a cluster in the right premotor cortex/middle frontal gyrus was related to more severe symptoms of repetitive behaviour. Conclusions: We demonstrate the fruitfulness of applying a cross-disorder approach to investigate the neural underpinnings of compulsivity/repetitive behaviour, by revealing a shared alteration in functional connectivity in ASD and OCD. We argue that this alteration might reflect aberrant reward or motivational processing of the NAcc with excessive connectivity to the premotor cortex implementing learned action patterns.
Keywords
DIAGNOSTIC INTERVIEW, MOTION CORRECTION, BASAL GANGLIA, ICA-AROMA, CHILDREN, RELIABILITY, METAANALYSIS, ADOLESCENTS, VERSION, ROBUST, Autism spectrum disorder (ASD), compulsivity, frontostriatal circuits, functional connectivity, functional magnetic resonance imaging (fMRI), nucleus accumbens, obsessive-compulsive disorder (OCD), repetitive, behaviour, resting state, striatum, transdiagnostic

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MLA
Akkermans, Sophie EA, et al. “Frontostriatal Functional Connectivity Correlates with Repetitive Behaviour across Autism Spectrum Disorder and Obsessive-Compulsive Disorder.” PSYCHOLOGICAL MEDICINE, vol. 49, no. 13, 2019, pp. 2247–55.
APA
Akkermans, S. E., Rheinheimer, N., Bruchhage, M. M., Durston, S., Brandeis, D., Banaschewski, T., … Auby, P. (2019). Frontostriatal functional connectivity correlates with repetitive behaviour across autism spectrum disorder and obsessive-compulsive disorder. PSYCHOLOGICAL MEDICINE, 49(13), 2247–2255.
Chicago author-date
Akkermans, Sophie EA, Nicole Rheinheimer, Muriel MK Bruchhage, Sarah Durston, Daniel Brandeis, Tobias Banaschewski, Regina Boecker-Schlier, et al. 2019. “Frontostriatal Functional Connectivity Correlates with Repetitive Behaviour across Autism Spectrum Disorder and Obsessive-Compulsive Disorder.” PSYCHOLOGICAL MEDICINE 49 (13): 2247–55.
Chicago author-date (all authors)
Akkermans, Sophie EA, Nicole Rheinheimer, Muriel MK Bruchhage, Sarah Durston, Daniel Brandeis, Tobias Banaschewski, Regina Boecker-Schlier, Isabella Wolf, Steven CR Williams, Jan K Buitelaar, Daan van Rooij, Marianne Oldehinkel, Saskia de Ruiter, Jilly Naaijen, Maarten Mennes, Marcel Zwiers, Shahrzad Ilbegi, Leonie Hennissen, Jeffrey Glennon, Ilse van de Vondervoort, Katarzyna Kapusta, Natalia Bielczyk, Houshang Amiri, Martha Havenith, Barbara Franke, Geert Poelmans, Janita Bralten, Tom Heskes, Elena Sokolova, Perry Groot, David Lythgoe, Iulia Dud, Ralf Dittmann, Konstantin Mechler, Ruth Berg, Alexander Hage, Sarah Hohmann, Matthias Ruf, Rick Dijkhuizen, Erwin Blezer, Kajo van der Marel, Pim Pullens, Wouter Mol, Annette van der Toorn, Willem Otte, Caroline van Heijningen, Vincent Mensen, Bob Oranje, Rene Mandl, Daphna Joel, John Cryan, Tracey Petryshen, David Pauls, Mai Saito, Angelique Heckman, Sabine Bahn, Ameli Schwalber, and Philippe Auby. 2019. “Frontostriatal Functional Connectivity Correlates with Repetitive Behaviour across Autism Spectrum Disorder and Obsessive-Compulsive Disorder.” PSYCHOLOGICAL MEDICINE 49 (13): 2247–2255.
Vancouver
1.
Akkermans SE, Rheinheimer N, Bruchhage MM, Durston S, Brandeis D, Banaschewski T, et al. Frontostriatal functional connectivity correlates with repetitive behaviour across autism spectrum disorder and obsessive-compulsive disorder. PSYCHOLOGICAL MEDICINE. 2019;49(13):2247–55.
IEEE
[1]
S. E. Akkermans et al., “Frontostriatal functional connectivity correlates with repetitive behaviour across autism spectrum disorder and obsessive-compulsive disorder,” PSYCHOLOGICAL MEDICINE, vol. 49, no. 13, pp. 2247–2255, 2019.
@article{8632120,
  abstract     = {Background: Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) are neurodevelopmental disorders with considerable overlap in terms of their defining symptoms of compulsivity/repetitive behaviour. Little is known about the extent to which ASD and OCD have common versus distinct neural correlates of compulsivity. Previous research points to potentially common dysfunction in frontostriatal connectivity, but direct comparisons in one study are lacking. Here, we assessed frontostriatal resting-state functional connectivity in youth with ASD or OCD, and healthy controls. In addition, we applied a cross-disorder approach to examine whether repetitive behaviour across ASD and OCD has common neural substrates.
Methods: A sample of 78 children and adolescents aged 8-16 years was used (ASD n = 24; OCD n = 25; healthy controls n = 29), originating from the multicentre study COMPULS. We tested whether diagnostic group, repetitive behaviour (measured with the Repetitive Behavior Scale-Revised) or their interaction was associated with resting-state functional connectivity of striatal seed regions.
Results: No diagnosis-specific differences were detected. The cross-disorder analysis, on the other hand, showed that increased functional connectivity between the left nucleus accumbens (NAcc) and a cluster in the right premotor cortex/middle frontal gyrus was related to more severe symptoms of repetitive behaviour.
Conclusions: We demonstrate the fruitfulness of applying a cross-disorder approach to investigate the neural underpinnings of compulsivity/repetitive behaviour, by revealing a shared alteration in functional connectivity in ASD and OCD. We argue that this alteration might reflect aberrant reward or motivational processing of the NAcc with excessive connectivity to the premotor cortex implementing learned action patterns.},
  author       = {Akkermans, Sophie EA and Rheinheimer, Nicole and Bruchhage, Muriel MK and Durston, Sarah and Brandeis, Daniel and Banaschewski, Tobias and Boecker-Schlier, Regina and Wolf, Isabella and Williams, Steven CR and Buitelaar, Jan K and van Rooij, Daan and Oldehinkel, Marianne and de Ruiter, Saskia and Naaijen, Jilly and Mennes, Maarten and Zwiers, Marcel and Ilbegi, Shahrzad and Hennissen, Leonie and Glennon, Jeffrey and van de Vondervoort, Ilse and Kapusta, Katarzyna and Bielczyk, Natalia and Amiri, Houshang and Havenith, Martha and Franke, Barbara and Poelmans, Geert and Bralten, Janita and Heskes, Tom and Sokolova, Elena and Groot, Perry and Lythgoe, David and Dud, Iulia and Dittmann, Ralf and Mechler, Konstantin and Berg, Ruth and Hage, Alexander and Hohmann, Sarah and Ruf, Matthias and Dijkhuizen, Rick and Blezer, Erwin and van der Marel, Kajo and Pullens, Pim and Mol, Wouter and van der Toorn, Annette and Otte, Willem and van Heijningen, Caroline and Mensen, Vincent and Oranje, Bob and Mandl, Rene and Joel, Daphna and Cryan, John and Petryshen, Tracey and Pauls, David and Saito, Mai and Heckman, Angelique and Bahn, Sabine and Schwalber, Ameli and Auby, Philippe},
  issn         = {0033-2917},
  journal      = {PSYCHOLOGICAL MEDICINE},
  keywords     = {DIAGNOSTIC INTERVIEW,MOTION CORRECTION,BASAL GANGLIA,ICA-AROMA,CHILDREN,RELIABILITY,METAANALYSIS,ADOLESCENTS,VERSION,ROBUST,Autism spectrum disorder (ASD),compulsivity,frontostriatal circuits,functional connectivity,functional magnetic resonance imaging (fMRI),nucleus accumbens,obsessive-compulsive disorder (OCD),repetitive,behaviour,resting state,striatum,transdiagnostic},
  language     = {eng},
  number       = {13},
  pages        = {2247--2255},
  title        = {Frontostriatal functional connectivity correlates with repetitive behaviour across autism spectrum disorder and obsessive-compulsive disorder},
  url          = {http://dx.doi.org/10.1017/S0033291718003136},
  volume       = {49},
  year         = {2019},
}

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