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A new evolutionary model for the vertebrate actin family including two novel groups

Laura Witjes (UGent) , Marleen Van Troys (UGent) , Joël Vandekerckhove (UGent) , Klaas Vandepoele (UGent) and Christophe Ampe (UGent)
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Abstract
Database surveys in the vertebrate model organisms: chicken (Gallus gallus), western clawed frog (Xenopus tropicalis), anole lizard (Anolis carolinensis) and zebrafish (Danio rerio) indicate that in some of these species the number of actin paralogues differs from the well-established six paralogues in mouse (Mus musculus). To investigate differential functions of actins and for establishing disease models it is important to know how actins in the different model organisms relate to each other and whether the vertebrate actin family is truly limited to six groups. Primarily through synteny analyses we discovered that the vertebrate actin family consists of eight instead of six orthologous actin groups for which we propose improved gene nomenclature. We also established that α-skeletal muscle, γ-enteric smooth muscle and γ-cytoplasmic actin genes originated prior to tetrapods contradicting an earlier and widely accepted model of actin evolution. Our findings allow a more reliable predictive classification of actin paralogues in (non-mammalian) vertebrates and contribute to a better understanding of actin evolution as basis for biomedical research on actin-related diseases.
Keywords
Genetics, Ecology, Evolution, Behavior and Systematics, Molecular Biology

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Please use this url to cite or link to this publication:

MLA
Witjes, Laura, et al. “A New Evolutionary Model for the Vertebrate Actin Family Including Two Novel Groups.” Molecular Phylogenetics and Evolution, vol. 414, 2019.
APA
Witjes, L., Van Troys, M., Vandekerckhove, J., Vandepoele, K., & Ampe, C. (2019). A new evolutionary model for the vertebrate actin family including two novel groups. Molecular Phylogenetics and Evolution, 414.
Chicago author-date
Witjes, Laura, Marleen Van Troys, Joël Vandekerckhove, Klaas Vandepoele, and Christophe Ampe. 2019. “A New Evolutionary Model for the Vertebrate Actin Family Including Two Novel Groups.” Molecular Phylogenetics and Evolution 414.
Chicago author-date (all authors)
Witjes, Laura, Marleen Van Troys, Joël Vandekerckhove, Klaas Vandepoele, and Christophe Ampe. 2019. “A New Evolutionary Model for the Vertebrate Actin Family Including Two Novel Groups.” Molecular Phylogenetics and Evolution 414.
Vancouver
1.
Witjes L, Van Troys M, Vandekerckhove J, Vandepoele K, Ampe C. A new evolutionary model for the vertebrate actin family including two novel groups. Molecular Phylogenetics and Evolution. 2019;414.
IEEE
[1]
L. Witjes, M. Van Troys, J. Vandekerckhove, K. Vandepoele, and C. Ampe, “A new evolutionary model for the vertebrate actin family including two novel groups,” Molecular Phylogenetics and Evolution, vol. 414, 2019.
@article{8632084,
  abstract     = {Database surveys in the vertebrate model organisms: chicken (Gallus gallus), western clawed frog (Xenopus tropicalis), anole lizard (Anolis carolinensis) and zebrafish (Danio rerio) indicate that in some of these species the number of actin paralogues differs from the well-established six paralogues in mouse (Mus musculus). To investigate differential functions of actins and for establishing disease models it is important to know how actins in the different model organisms relate to each other and whether the vertebrate actin family is truly limited to six groups. Primarily through synteny analyses we discovered that the vertebrate actin family consists of eight instead of six orthologous actin groups for which we propose improved gene nomenclature. We also established that α-skeletal muscle, γ-enteric smooth muscle and γ-cytoplasmic actin genes originated prior to tetrapods contradicting an earlier and widely accepted model of actin evolution. Our findings allow a more reliable predictive classification of actin paralogues in (non-mammalian) vertebrates and contribute to a better understanding of actin evolution as basis for biomedical research on actin-related diseases.},
  articleno    = {106632},
  author       = {Witjes, Laura and Van Troys, Marleen and Vandekerckhove, Joël and Vandepoele, Klaas and Ampe, Christophe},
  issn         = {1055-7903},
  journal      = {Molecular Phylogenetics and Evolution},
  keywords     = {Genetics,Ecology,Evolution,Behavior and Systematics,Molecular Biology},
  language     = {eng},
  title        = {A new evolutionary model for the vertebrate actin family including two novel groups},
  url          = {http://dx.doi.org/10.1016/j.ympev.2019.106632},
  volume       = {414},
  year         = {2019},
}

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