Advanced search
1 file | 3.11 MB Add to list

Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells

Annemiek Uvyn (UGent) , Ruben De Coen, Olivier De Wever (UGent) , Kim Deswarte (UGent) , Bart Lambrecht (UGent) and Bruno De Geest (UGent)
(2019) CHEMICAL COMMUNICATIONS. 55(73). p.10952-10955
Author
Organization
Abstract
Triggering antibody-mediated innate immune mechanisms to kill cancer cells is an attractive therapeutic avenue. In this context, recruitment of endogenous antibodies to the cancer cell surface could be a viable alternative to the use of monoclonal antibodies. We report on antibody-recruiting polymers containing multiple antibody-binding hapten motifs and cyclooctynes that can covalently conjugate to azides introduced onto the glycocalyx of cancer cells by metabolic labeling with azido sugars.
Keywords
MOLECULES, INNATE

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 3.11 MB

Citation

Please use this url to cite or link to this publication:

MLA
Uvyn, Annemiek, et al. “Cell Surface Clicking of Antibody-Recruiting Polymers to Metabolically Azide-Labeled Cancer Cells.” CHEMICAL COMMUNICATIONS, vol. 55, no. 73, 2019, pp. 10952–55.
APA
Uvyn, A., De Coen, R., De Wever, O., Deswarte, K., Lambrecht, B., & De Geest, B. (2019). Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells. CHEMICAL COMMUNICATIONS, 55(73), 10952–10955.
Chicago author-date
Uvyn, Annemiek, Ruben De Coen, Olivier De Wever, Kim Deswarte, Bart Lambrecht, and Bruno De Geest. 2019. “Cell Surface Clicking of Antibody-Recruiting Polymers to Metabolically Azide-Labeled Cancer Cells.” CHEMICAL COMMUNICATIONS 55 (73): 10952–55.
Chicago author-date (all authors)
Uvyn, Annemiek, Ruben De Coen, Olivier De Wever, Kim Deswarte, Bart Lambrecht, and Bruno De Geest. 2019. “Cell Surface Clicking of Antibody-Recruiting Polymers to Metabolically Azide-Labeled Cancer Cells.” CHEMICAL COMMUNICATIONS 55 (73): 10952–10955.
Vancouver
1.
Uvyn A, De Coen R, De Wever O, Deswarte K, Lambrecht B, De Geest B. Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells. CHEMICAL COMMUNICATIONS. 2019;55(73):10952–5.
IEEE
[1]
A. Uvyn, R. De Coen, O. De Wever, K. Deswarte, B. Lambrecht, and B. De Geest, “Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells,” CHEMICAL COMMUNICATIONS, vol. 55, no. 73, pp. 10952–10955, 2019.
@article{8631711,
  abstract     = {{Triggering antibody-mediated innate immune mechanisms to kill cancer cells is an attractive therapeutic avenue. In this context, recruitment of endogenous antibodies to the cancer cell surface could be a viable alternative to the use of monoclonal antibodies. We report on antibody-recruiting polymers containing multiple antibody-binding hapten motifs and cyclooctynes that can covalently conjugate to azides introduced onto the glycocalyx of cancer cells by metabolic labeling with azido sugars.}},
  author       = {{Uvyn, Annemiek and De Coen, Ruben and De Wever, Olivier and Deswarte, Kim and Lambrecht, Bart and De Geest, Bruno}},
  issn         = {{1359-7345}},
  journal      = {{CHEMICAL COMMUNICATIONS}},
  keywords     = {{MOLECULES,INNATE}},
  language     = {{eng}},
  number       = {{73}},
  pages        = {{10952--10955}},
  title        = {{Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells}},
  url          = {{http://dx.doi.org/10.1039/c9cc03379c}},
  volume       = {{55}},
  year         = {{2019}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: