Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells
- Author
- Annemiek Uvyn (UGent) , Ruben De Coen (UGent) , Olivier De Wever (UGent) , Kim Deswarte (UGent) , Bart Lambrecht (UGent) and Bruno De Geest (UGent)
- Organization
- Abstract
- Triggering antibody-mediated innate immune mechanisms to kill cancer cells is an attractive therapeutic avenue. In this context, recruitment of endogenous antibodies to the cancer cell surface could be a viable alternative to the use of monoclonal antibodies. We report on antibody-recruiting polymers containing multiple antibody-binding hapten motifs and cyclooctynes that can covalently conjugate to azides introduced onto the glycocalyx of cancer cells by metabolic labeling with azido sugars.
- Keywords
- MOLECULES, INNATE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8631711
- MLA
- Uvyn, Annemiek, et al. “Cell Surface Clicking of Antibody-Recruiting Polymers to Metabolically Azide-Labeled Cancer Cells.” CHEMICAL COMMUNICATIONS, vol. 55, no. 73, 2019, pp. 10952–55, doi:10.1039/c9cc03379c.
- APA
- Uvyn, A., De Coen, R., De Wever, O., Deswarte, K., Lambrecht, B., & De Geest, B. (2019). Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells. CHEMICAL COMMUNICATIONS, 55(73), 10952–10955. https://doi.org/10.1039/c9cc03379c
- Chicago author-date
- Uvyn, Annemiek, Ruben De Coen, Olivier De Wever, Kim Deswarte, Bart Lambrecht, and Bruno De Geest. 2019. “Cell Surface Clicking of Antibody-Recruiting Polymers to Metabolically Azide-Labeled Cancer Cells.” CHEMICAL COMMUNICATIONS 55 (73): 10952–55. https://doi.org/10.1039/c9cc03379c.
- Chicago author-date (all authors)
- Uvyn, Annemiek, Ruben De Coen, Olivier De Wever, Kim Deswarte, Bart Lambrecht, and Bruno De Geest. 2019. “Cell Surface Clicking of Antibody-Recruiting Polymers to Metabolically Azide-Labeled Cancer Cells.” CHEMICAL COMMUNICATIONS 55 (73): 10952–10955. doi:10.1039/c9cc03379c.
- Vancouver
- 1.Uvyn A, De Coen R, De Wever O, Deswarte K, Lambrecht B, De Geest B. Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells. CHEMICAL COMMUNICATIONS. 2019;55(73):10952–5.
- IEEE
- [1]A. Uvyn, R. De Coen, O. De Wever, K. Deswarte, B. Lambrecht, and B. De Geest, “Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells,” CHEMICAL COMMUNICATIONS, vol. 55, no. 73, pp. 10952–10955, 2019.
@article{8631711,
abstract = {{Triggering antibody-mediated innate immune mechanisms to kill cancer cells is an attractive therapeutic avenue. In this context, recruitment of endogenous antibodies to the cancer cell surface could be a viable alternative to the use of monoclonal antibodies. We report on antibody-recruiting polymers containing multiple antibody-binding hapten motifs and cyclooctynes that can covalently conjugate to azides introduced onto the glycocalyx of cancer cells by metabolic labeling with azido sugars.}},
author = {{Uvyn, Annemiek and De Coen, Ruben and De Wever, Olivier and Deswarte, Kim and Lambrecht, Bart and De Geest, Bruno}},
issn = {{1359-7345}},
journal = {{CHEMICAL COMMUNICATIONS}},
keywords = {{MOLECULES,INNATE}},
language = {{eng}},
number = {{73}},
pages = {{10952--10955}},
title = {{Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells}},
url = {{http://dx.doi.org/10.1039/c9cc03379c}},
volume = {{55}},
year = {{2019}},
}
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