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Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells

Annemiek Uvyn (UGent) , Ruben De Coen (UGent) , Olivier De Wever (UGent) , Kim Deswarte (UGent) , Bart Lambrecht (UGent) and Bruno De Geest (UGent)
(2019) CHEMICAL COMMUNICATIONS. 55(73). p.10952-10955
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Abstract
Triggering antibody-mediated innate immune mechanisms to kill cancer cells is an attractive therapeutic avenue. In this context, recruitment of endogenous antibodies to the cancer cell surface could be a viable alternative to the use of monoclonal antibodies. We report on antibody-recruiting polymers containing multiple antibody-binding hapten motifs and cyclooctynes that can covalently conjugate to azides introduced onto the glycocalyx of cancer cells by metabolic labeling with azido sugars.
Keywords
MOLECULES, INNATE

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Citation

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MLA
Uvyn, Annemiek, et al. “Cell Surface Clicking of Antibody-Recruiting Polymers to Metabolically Azide-Labeled Cancer Cells.” CHEMICAL COMMUNICATIONS, vol. 55, no. 73, 2019, pp. 10952–55.
APA
Uvyn, A., De Coen, R., De Wever, O., Deswarte, K., Lambrecht, B., & De Geest, B. (2019). Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells. CHEMICAL COMMUNICATIONS, 55(73), 10952–10955.
Chicago author-date
Uvyn, Annemiek, Ruben De Coen, Olivier De Wever, Kim Deswarte, Bart Lambrecht, and Bruno De Geest. 2019. “Cell Surface Clicking of Antibody-Recruiting Polymers to Metabolically Azide-Labeled Cancer Cells.” CHEMICAL COMMUNICATIONS 55 (73): 10952–55.
Chicago author-date (all authors)
Uvyn, Annemiek, Ruben De Coen, Olivier De Wever, Kim Deswarte, Bart Lambrecht, and Bruno De Geest. 2019. “Cell Surface Clicking of Antibody-Recruiting Polymers to Metabolically Azide-Labeled Cancer Cells.” CHEMICAL COMMUNICATIONS 55 (73): 10952–10955.
Vancouver
1.
Uvyn A, De Coen R, De Wever O, Deswarte K, Lambrecht B, De Geest B. Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells. CHEMICAL COMMUNICATIONS. 2019;55(73):10952–5.
IEEE
[1]
A. Uvyn, R. De Coen, O. De Wever, K. Deswarte, B. Lambrecht, and B. De Geest, “Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells,” CHEMICAL COMMUNICATIONS, vol. 55, no. 73, pp. 10952–10955, 2019.
@article{8631711,
  abstract     = {Triggering antibody-mediated innate immune mechanisms to kill cancer cells is an attractive therapeutic avenue. In this context, recruitment of endogenous antibodies to the cancer cell surface could be a viable alternative to the use of monoclonal antibodies. We report on antibody-recruiting polymers containing multiple antibody-binding hapten motifs and cyclooctynes that can covalently conjugate to azides introduced onto the glycocalyx of cancer cells by metabolic labeling with azido sugars.},
  author       = {Uvyn, Annemiek and De Coen, Ruben and De Wever, Olivier and Deswarte, Kim and Lambrecht, Bart and De Geest, Bruno},
  issn         = {1359-7345},
  journal      = {CHEMICAL COMMUNICATIONS},
  keywords     = {MOLECULES,INNATE},
  language     = {eng},
  number       = {73},
  pages        = {10952--10955},
  title        = {Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells},
  url          = {http://dx.doi.org/10.1039/c9cc03379c},
  volume       = {55},
  year         = {2019},
}

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