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Airway morphometry in COPD with bronchiectasis : a view on all airway generations

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Abstract
The pathophysiological processes underlying bronchiectasis in chronic obstructive pulmonary disease (COPD) are not understood. In COPD, both small and large airways are progressively lost. It is currently not known to what extent the different airway generations of patients with COPD and bronchiectasis are involved. COPD explant lungs with bronchiectasis were compared to COPD explant lungs without bronchiectasis and unused donor lungs as controls. In order to investigate all airway generations, a multimodal imaging approach using different resolutions was conducted. Per group, five lungs were frozen (n=15) and underwent computed tomography (CT) imaging for large airway evaluation, with four tissue cores per lung imaged for measurements of the terminal bronchioles. Two additional lungs per group (n=6) were air-dried for lobar microCT images that allow airway segmentation and three-dimensional quantification of the complete airway tree. COPD lungs with bronchiectasis had significantly more airways compared to COPD lungs without bronchiectasis (p<0.001), with large airway numbers similar to control lungs. This difference was present in both upper and lower lobes. Lack of tapering was present (p=0.010) and larger diameters were demonstrated in lower lobes with bronchiectasis (p=0.010). MicroCT analysis of tissue cores showed similar reductions of tissue percentage, surface density and number of terminal bronchioles in both COPD groups compared to control lungs. Although terminal bronchioles were equally reduced in COPD lungs with and without bronchiectasis, significantly more large and small airways were found in COPD lungs with bronchiectasis.
Keywords
OBSTRUCTIVE PULMONARY-DISEASE, COMPUTED-TOMOGRAPHY, ADULTS, MORTALITY, EMPHYSEMA, SOCIETY, LUNGS

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MLA
Everaerts, Stephanie, et al. “Airway Morphometry in COPD with Bronchiectasis : A View on All Airway Generations.” EUROPEAN RESPIRATORY JOURNAL, vol. 54, 2019.
APA
Everaerts, S., McDonough, J. E., Verleden, S. E., Josipovic, I., Boone, M., Dubbeldam, A., … Janssens, W. (2019). Airway morphometry in COPD with bronchiectasis : a view on all airway generations. EUROPEAN RESPIRATORY JOURNAL, 54.
Chicago author-date
Everaerts, Stephanie, John E McDonough, Stijn E Verleden, Iván Josipovic, Matthieu Boone, Adriana Dubbeldam, Carolien Mathyssen, et al. 2019. “Airway Morphometry in COPD with Bronchiectasis : A View on All Airway Generations.” EUROPEAN RESPIRATORY JOURNAL 54.
Chicago author-date (all authors)
Everaerts, Stephanie, John E McDonough, Stijn E Verleden, Iván Josipovic, Matthieu Boone, Adriana Dubbeldam, Carolien Mathyssen, Jef Serré, Lieven J Dupont, Ghislaine Gayan-Ramirez, Johny Verschakelen, James C Hogg, Geert M Verleden, Bart M Vanaudenaerde, and Wim Janssens. 2019. “Airway Morphometry in COPD with Bronchiectasis : A View on All Airway Generations.” EUROPEAN RESPIRATORY JOURNAL 54.
Vancouver
1.
Everaerts S, McDonough JE, Verleden SE, Josipovic I, Boone M, Dubbeldam A, et al. Airway morphometry in COPD with bronchiectasis : a view on all airway generations. EUROPEAN RESPIRATORY JOURNAL. 2019;54.
IEEE
[1]
S. Everaerts et al., “Airway morphometry in COPD with bronchiectasis : a view on all airway generations,” EUROPEAN RESPIRATORY JOURNAL, vol. 54, 2019.
@article{8631647,
  abstract     = {The pathophysiological processes underlying bronchiectasis in chronic obstructive pulmonary disease (COPD) are not understood. In COPD, both small and large airways are progressively lost. It is currently not known to what extent the different airway generations of patients with COPD and bronchiectasis are involved. 
COPD explant lungs with bronchiectasis were compared to COPD explant lungs without bronchiectasis and unused donor lungs as controls. In order to investigate all airway generations, a multimodal imaging approach using different resolutions was conducted. Per group, five lungs were frozen (n=15) and underwent computed tomography (CT) imaging for large airway evaluation, with four tissue cores per lung imaged for measurements of the terminal bronchioles. Two additional lungs per group (n=6) were air-dried for lobar microCT images that allow airway segmentation and three-dimensional quantification of the complete airway tree. 
COPD lungs with bronchiectasis had significantly more airways compared to COPD lungs without bronchiectasis (p<0.001), with large airway numbers similar to control lungs. This difference was present in both upper and lower lobes. Lack of tapering was present (p=0.010) and larger diameters were demonstrated in lower lobes with bronchiectasis (p=0.010). MicroCT analysis of tissue cores showed similar reductions of tissue percentage, surface density and number of terminal bronchioles in both COPD groups compared to control lungs. 
Although terminal bronchioles were equally reduced in COPD lungs with and without bronchiectasis, significantly more large and small airways were found in COPD lungs with bronchiectasis.},
  articleno    = {1802166},
  author       = {Everaerts, Stephanie and McDonough, John E and Verleden, Stijn E and Josipovic, Iván and Boone, Matthieu and Dubbeldam, Adriana and Mathyssen, Carolien and Serré, Jef and Dupont, Lieven J and Gayan-Ramirez, Ghislaine and Verschakelen, Johny and Hogg, James C and Verleden, Geert M and Vanaudenaerde, Bart M and Janssens, Wim},
  issn         = {0903-1936},
  journal      = {EUROPEAN RESPIRATORY JOURNAL},
  keywords     = {OBSTRUCTIVE PULMONARY-DISEASE,COMPUTED-TOMOGRAPHY,ADULTS,MORTALITY,EMPHYSEMA,SOCIETY,LUNGS},
  language     = {eng},
  pages        = {10},
  title        = {Airway morphometry in COPD with bronchiectasis : a view on all airway generations},
  url          = {http://dx.doi.org/10.1183/13993003.02166-2018},
  volume       = {54},
  year         = {2019},
}

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