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Feed restriction to induce and meloxicam to mitigate potential systemic inflammation in dairy cows before calving

(2019) JOURNAL OF DAIRY SCIENCE. 102(10). p.9285-9297
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Abstract
Most dairy cows experience a transient decrease in feed intake in the 1 to 2 wk before calving, which has been associated with systemic inflammation (SI), indicated by increased blood haptoglobin (Hp) concentration. We aimed to characterize the association between prepartum decrease in feed intake and the onset of SI and, if present, the ability of meloxicam (MEL), a nonsteroidal anti-inflammatory drug, to mitigate SI. Holstein cows (n = 45) were assigned to control (n = 13), feed restriction (FR) untreated (FR-U; n = 15), and FR treated with MEL (FR-T; n = 17) groups. Daily feed intake was measured from -22 d from expected parturition until 35 d postpartum. Control cows were fed ad libitum, whereas FR-U and FR-T cows were reduced to 60% of their average intake for 4 consecutive days (-15 to -12 d from expected calving). The FR-T cows received MEL (0.5 mg/kg of body weight) once daily for 4 consecutive days (-13 to -10 d from expected calving). Blood samples were collected -22, -15, -14, 13, -12, -10, -7, -5, -3, 0, 1, 3, 5, 7, 15, 22, and 35 d relative to calving to measure serum concentrations of total calcium, total protein, albumin, globulin, cholesterol, urea, glucose, gamma-glutamyl transferase, aspartate aminotransferase, glutamate dehydrogenase, beta-hydroxybutyrate, nonesterified fatty acids, Hp, and insulin-like growth factor-1. Serum concentrations of lipopolysaccharide-binding protein were measured -22, -15, -14, -13, -12, and -10 d from expected calving. Simplified glucose tolerance tests were performed on -15, -12, -5, 1, and 5 d relative to calving. Mixed linear regression models were used to assess the effects of FR and MEL on each metabolite. The interaction between treatment group and blood sampling day was forced into each model. All models accounted for body condition score, parity, and the cow as a random effect. Nonesterified fatty acids concentrations in both the FR-li and FR-T groups significantly increased from the second until the last day of FR. Feed restriction increased urea concentrations compared with the control group on -14 d but decreased urea concentrations on -10 d from expected calving. Control cows had greater beta-hydroxybutyrate concentrations compared with FR cows on 15, 21, and 35 d postpartum. For all other metabolites, no differences were found. This model of FR produced substantial fat mobilization but based on serum Hp and lipopolysaccharide-binding protein concentrations did not generate measurable SI; therefore, we were unable to evaluate the ability of MEL to mitigate SI.
Keywords
transition period, nonsteroidal anti-inflammatory, metabolic inflammation, NONESTERIFIED FATTY-ACIDS, WHOLE-LACTATION MILK, BODY CONDITION SCORE, INSULIN-RESISTANCE, BETA-HYDROXYBUTYRATE, SALICYLATE TREATMENT, IMMUNE-SYSTEM, TRANSITION, HEALTH, METABOLISM

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MLA
Bogado Pascottini, Osvaldo Américo, et al. “Feed Restriction to Induce and Meloxicam to Mitigate Potential Systemic Inflammation in Dairy Cows before Calving.” JOURNAL OF DAIRY SCIENCE, vol. 102, no. 10, 2019, pp. 9285–97.
APA
Bogado Pascottini, O. A., Carvalho, M., Van Schyndel, S., Ticiani, E., Spricigo, J., Mamedova, L., … LeBlanc, S. (2019). Feed restriction to induce and meloxicam to mitigate potential systemic inflammation in dairy cows before calving. JOURNAL OF DAIRY SCIENCE, 102(10), 9285–9297.
Chicago author-date
Bogado Pascottini, Osvaldo Américo, MR Carvalho, SJ Van Schyndel, E Ticiani, JW Spricigo, LK Mamedova, ES Ribeiro, and SJ LeBlanc. 2019. “Feed Restriction to Induce and Meloxicam to Mitigate Potential Systemic Inflammation in Dairy Cows before Calving.” JOURNAL OF DAIRY SCIENCE 102 (10): 9285–97.
Chicago author-date (all authors)
Bogado Pascottini, Osvaldo Américo, MR Carvalho, SJ Van Schyndel, E Ticiani, JW Spricigo, LK Mamedova, ES Ribeiro, and SJ LeBlanc. 2019. “Feed Restriction to Induce and Meloxicam to Mitigate Potential Systemic Inflammation in Dairy Cows before Calving.” JOURNAL OF DAIRY SCIENCE 102 (10): 9285–9297.
Vancouver
1.
Bogado Pascottini OA, Carvalho M, Van Schyndel S, Ticiani E, Spricigo J, Mamedova L, et al. Feed restriction to induce and meloxicam to mitigate potential systemic inflammation in dairy cows before calving. JOURNAL OF DAIRY SCIENCE. 2019;102(10):9285–97.
IEEE
[1]
O. A. Bogado Pascottini et al., “Feed restriction to induce and meloxicam to mitigate potential systemic inflammation in dairy cows before calving,” JOURNAL OF DAIRY SCIENCE, vol. 102, no. 10, pp. 9285–9297, 2019.
@article{8630765,
  abstract     = {Most dairy cows experience a transient decrease in feed intake in the 1 to 2 wk before calving, which has been associated with systemic inflammation (SI), indicated by increased blood haptoglobin (Hp) concentration. We aimed to characterize the association between prepartum decrease in feed intake and the onset of SI and, if present, the ability of meloxicam (MEL), a nonsteroidal anti-inflammatory drug, to mitigate SI. Holstein cows (n = 45) were assigned to control (n = 13), feed restriction (FR) untreated (FR-U; n = 15), and FR treated with MEL (FR-T; n = 17) groups. Daily feed intake was measured from -22 d from expected parturition until 35 d postpartum. Control cows were fed ad libitum, whereas FR-U and FR-T cows were reduced to 60% of their average intake for 4 consecutive days (-15 to -12 d from expected calving). The FR-T cows received MEL (0.5 mg/kg of body weight) once daily for 4 consecutive days (-13 to -10 d from expected calving). Blood samples were collected -22, -15, -14, 13, -12, -10, -7, -5, -3, 0, 1, 3, 5, 7, 15, 22, and 35 d relative to calving to measure serum concentrations of total calcium, total protein, albumin, globulin, cholesterol, urea, glucose, gamma-glutamyl transferase, aspartate aminotransferase, glutamate dehydrogenase, beta-hydroxybutyrate, nonesterified fatty acids, Hp, and insulin-like growth factor-1. Serum concentrations of lipopolysaccharide-binding protein were measured -22, -15, -14, -13, -12, and -10 d from expected calving. Simplified glucose tolerance tests were performed on -15, -12, -5, 1, and 5 d relative to calving. Mixed linear regression models were used to assess the effects of FR and MEL on each metabolite. The interaction between treatment group and blood sampling day was forced into each model. All models accounted for body condition score, parity, and the cow as a random effect. Nonesterified fatty acids concentrations in both the FR-li and FR-T groups significantly increased from the second until the last day of FR. Feed restriction increased urea concentrations compared with the control group on -14 d but decreased urea concentrations on -10 d from expected calving. Control cows had greater beta-hydroxybutyrate concentrations compared with FR cows on 15, 21, and 35 d postpartum. For all other metabolites, no differences were found. This model of FR produced substantial fat mobilization but based on serum Hp and lipopolysaccharide-binding protein concentrations did not generate measurable SI; therefore, we were unable to evaluate the ability of MEL to mitigate SI.},
  author       = {Bogado Pascottini, Osvaldo Américo and Carvalho, MR and Van Schyndel, SJ and Ticiani, E and Spricigo, JW and Mamedova, LK and Ribeiro, ES and LeBlanc, SJ},
  issn         = {0022-0302},
  journal      = {JOURNAL OF DAIRY SCIENCE},
  keywords     = {transition period,nonsteroidal anti-inflammatory,metabolic inflammation,NONESTERIFIED FATTY-ACIDS,WHOLE-LACTATION MILK,BODY CONDITION SCORE,INSULIN-RESISTANCE,BETA-HYDROXYBUTYRATE,SALICYLATE TREATMENT,IMMUNE-SYSTEM,TRANSITION,HEALTH,METABOLISM},
  language     = {eng},
  number       = {10},
  pages        = {9285--9297},
  title        = {Feed restriction to induce and meloxicam to mitigate potential systemic inflammation in dairy cows before calving},
  url          = {http://dx.doi.org/10.3168/jds.2019-16558},
  volume       = {102},
  year         = {2019},
}

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