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Influence of health interventions on quality of life in seriously ill children at the end of life : a systematic review protocol

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Abstract
Background: Seriously ill children suffer from numerous symptoms at the end of their lives, including pain, anxiety, and restricted communication. There are currently no comprehensive overviews of which health interventions have proven benefits and which have proven detrimental effects on the quality of life of children in an end-of-life context. In order to identify potential quality indicators to eventually improve care, a systematic review of available evidence is needed. The aim of the current systematic review will be to make an overview of the influence of health interventions on associated outcomes related to quality of life at the end of life in seriously ill children. Methods: A systematic search will be conducted in MEDLINE, Embase, CENTRAL, CINAHL, and Web of Science. We will include quantitative empirical designs looking into the influence of a health intervention on (proxies of) quality of life at the end of life in seriously ill children. Three independent authors will review titles and abstracts and screen full texts against eligibility criteria. One reviewer will carry out full data extraction and quality assessment, and a 20% random sample will be extracted and assessed by two independent reviewers. We will use the QualSyst Tool for assessment of the quality of the included studies (QualSyst Tool) for quality assessment; overall strength of the body of evidence will be assessed using the Grading of Recommendations Assessment Development, and Evaluation (GRADE) approach. An overview table of health interventions will be discussed through narrative synthesis. Should sufficient homogeneous publications arise, we will perform meta-analyses with a random-effects model. Our protocol adheres to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) checklist for study protocols. Discussion: As part of a larger project, we will use the results of this review to identify a first set of quality indicators for the care for children at the end of life. Reviewing the current span of evidence and identifying research gaps will uncover future research priorities into the care for children at the end of life.
Keywords
Children, Pediatrics, End of life, Seriously ill, Quality of life, Health intervention, Review, Systematic, Symptom control, PALLIATIVE CARE, CANCER, SYMPTOMS, PERSPECTIVES, INDICATORS, SERVICES

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MLA
Piette, Veerle E., et al. “Influence of Health Interventions on Quality of Life in Seriously Ill Children at the End of Life : A Systematic Review Protocol.” SYSTEMATIC REVIEWS, vol. 8, 2019.
APA
Piette, V. E., Cohen, J., Deliens, L., Pauwels, N., van der Werff ten Bosch, J., & Beernaert, K. (2019). Influence of health interventions on quality of life in seriously ill children at the end of life : a systematic review protocol. SYSTEMATIC REVIEWS, 8.
Chicago author-date
Piette, Veerle E, Joachim Cohen, Luc Deliens, Nele Pauwels, Jutte van der Werff ten Bosch, and Kim Beernaert. 2019. “Influence of Health Interventions on Quality of Life in Seriously Ill Children at the End of Life : A Systematic Review Protocol.” SYSTEMATIC REVIEWS 8.
Chicago author-date (all authors)
Piette, Veerle E, Joachim Cohen, Luc Deliens, Nele Pauwels, Jutte van der Werff ten Bosch, and Kim Beernaert. 2019. “Influence of Health Interventions on Quality of Life in Seriously Ill Children at the End of Life : A Systematic Review Protocol.” SYSTEMATIC REVIEWS 8.
Vancouver
1.
Piette VE, Cohen J, Deliens L, Pauwels N, van der Werff ten Bosch J, Beernaert K. Influence of health interventions on quality of life in seriously ill children at the end of life : a systematic review protocol. SYSTEMATIC REVIEWS. 2019;8.
IEEE
[1]
V. E. Piette, J. Cohen, L. Deliens, N. Pauwels, J. van der Werff ten Bosch, and K. Beernaert, “Influence of health interventions on quality of life in seriously ill children at the end of life : a systematic review protocol,” SYSTEMATIC REVIEWS, vol. 8, 2019.
@article{8626207,
  abstract     = {Background: Seriously ill children suffer from numerous symptoms at the end of their lives, including pain, anxiety, and restricted communication. There are currently no comprehensive overviews of which health interventions have proven benefits and which have proven detrimental effects on the quality of life of children in an end-of-life context. In order to identify potential quality indicators to eventually improve care, a systematic review of available evidence is needed. The aim of the current systematic review will be to make an overview of the influence of health interventions on associated outcomes related to quality of life at the end of life in seriously ill children. 
Methods: A systematic search will be conducted in MEDLINE, Embase, CENTRAL, CINAHL, and Web of Science. We will include quantitative empirical designs looking into the influence of a health intervention on (proxies of) quality of life at the end of life in seriously ill children. Three independent authors will review titles and abstracts and screen full texts against eligibility criteria. One reviewer will carry out full data extraction and quality assessment, and a 20% random sample will be extracted and assessed by two independent reviewers. We will use the QualSyst Tool for assessment of the quality of the included studies (QualSyst Tool) for quality assessment; overall strength of the body of evidence will be assessed using the Grading of Recommendations Assessment Development, and Evaluation (GRADE) approach. An overview table of health interventions will be discussed through narrative synthesis. Should sufficient homogeneous publications arise, we will perform meta-analyses with a random-effects model. Our protocol adheres to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) checklist for study protocols. 
Discussion: As part of a larger project, we will use the results of this review to identify a first set of quality indicators for the care for children at the end of life. Reviewing the current span of evidence and identifying research gaps will uncover future research priorities into the care for children at the end of life.},
  articleno    = {165},
  author       = {Piette, Veerle E and Cohen, Joachim and Deliens, Luc and Pauwels, Nele and van der Werff ten Bosch, Jutte and Beernaert, Kim},
  issn         = {2046-4053},
  journal      = {SYSTEMATIC REVIEWS},
  keywords     = {Children,Pediatrics,End of life,Seriously ill,Quality of life,Health intervention,Review,Systematic,Symptom control,PALLIATIVE CARE,CANCER,SYMPTOMS,PERSPECTIVES,INDICATORS,SERVICES},
  language     = {eng},
  pages        = {8},
  title        = {Influence of health interventions on quality of life in seriously ill children at the end of life : a systematic review protocol},
  url          = {http://dx.doi.org/10.1186/s13643-019-1059-8},
  volume       = {8},
  year         = {2019},
}

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