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In-hospital and 12-month follow-up outcome from the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term registry : sex differences

(2020) EUROPACE. 22(1). p.66-73
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Abstract
Aim The purpose of this study was to compare sex differences of atrial fibrillation (AF) catheter ablation (CA) and to analyse the opportunities for improved outcomes. Methods and results All data were collected from the Atrial Fibrillation Ablation Long-Term registry, a prospective, multinational study conducted by the ESC-EORP European Heart Rhythm Association (EHRA) under the EURObservational Research Programme (ESC-EORP). A total of 104 centres in 27 European countries participated. Of 3593 included patients, 1146 (31.9%) were female. Female patients were older (61.0 vs. 56.4 years; P < 0.001), had more comorbidities (hypertension, diabetes, and obesity), more episodes of arrhythmias per month (6.9 vs. 6.2; P < 0.001), and a higher average EHRA score (2.6 vs. 2.4; P < 0.001). The duration of the procedure was shorter in females (160.1 min vs. 167.9 min; P < 0.001), irrespective of additional ablation lesions added to pulmonary vein isolation. Overall cardiovascular complications were more frequent in women than in men (5.7% vs. 3.4%; P < 0.001). Furthermore, cardiac perforations (3.8% vs. 1.3%; P = 0.011) and neurological complications (2.2% vs. 0.3%; P = 0.004) were found in females in less experienced centres than in experienced ones. On a final note, at 12 months, AF recurrence rate was similar in females and males (34.4% vs. 34.2%; P = 0.897), but more females were still on antiarrhythmic drugs (50.6% vs. 44.1%; P < 0.001) when compared with men. Conclusion Females underwent CA procedures for AF less frequently than males throughout Europe, despite more recurrent symptoms. With the same success rate, severe acute complications remained considerable in females, especially in less experienced centres.
Keywords
Atrial fibrillation, Catheter ablation, Sex differences, Gender differences, Registry, GENDER-RELATED DIFFERENCES, CATHETER ABLATION, EUROPEAN-SOCIETY, MANAGEMENT, EFFICACY, REGISTRY, SAFETY, HEART

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MLA
Grecu, Mihaela, et al. “In-Hospital and 12-Month Follow-up Outcome from the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term Registry : Sex Differences.” EUROPACE, vol. 22, no. 1, 2020, pp. 66–73, doi:10.1093/europace/euz225.
APA
Grecu, M., Blomström-Lundqvist, C., Kautzner, J., Laroche, C., Van Gelder, I. C., Jordaens, L., … Arbelo, E. (2020). In-hospital and 12-month follow-up outcome from the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term registry : sex differences. EUROPACE, 22(1), 66–73. https://doi.org/10.1093/europace/euz225
Chicago author-date
Grecu, Mihaela, Carina Blomström-Lundqvist, Josef Kautzner, Cecile Laroche, Isabelle C Van Gelder, Luc Jordaens, Luigi Tavazzi, et al. 2020. “In-Hospital and 12-Month Follow-up Outcome from the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term Registry : Sex Differences.” EUROPACE 22 (1): 66–73. https://doi.org/10.1093/europace/euz225.
Chicago author-date (all authors)
Grecu, Mihaela, Carina Blomström-Lundqvist, Josef Kautzner, Cecile Laroche, Isabelle C Van Gelder, Luc Jordaens, Luigi Tavazzi, Robert Cihak, Jose Manuel Rubio Campal, Zbigniew Kalarus, Evgeny Pokushalov, Josep Brugada, Nikolaos Dagres, and Elena Arbelo. 2020. “In-Hospital and 12-Month Follow-up Outcome from the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term Registry : Sex Differences.” EUROPACE 22 (1): 66–73. doi:10.1093/europace/euz225.
Vancouver
1.
Grecu M, Blomström-Lundqvist C, Kautzner J, Laroche C, Van Gelder IC, Jordaens L, et al. In-hospital and 12-month follow-up outcome from the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term registry : sex differences. EUROPACE. 2020;22(1):66–73.
IEEE
[1]
M. Grecu et al., “In-hospital and 12-month follow-up outcome from the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term registry : sex differences,” EUROPACE, vol. 22, no. 1, pp. 66–73, 2020.
@article{8625939,
  abstract     = {Aim The purpose of this study was to compare sex differences of atrial fibrillation (AF) catheter ablation (CA) and to analyse the opportunities for improved outcomes.

Methods and results All data were collected from the Atrial Fibrillation Ablation Long-Term registry, a prospective, multinational study conducted by the ESC-EORP European Heart Rhythm Association (EHRA) under the EURObservational Research Programme (ESC-EORP). A total of 104 centres in 27 European countries participated. Of 3593 included patients, 1146 (31.9%) were female. Female patients were older (61.0 vs. 56.4 years; P < 0.001), had more comorbidities (hypertension, diabetes, and obesity), more episodes of arrhythmias per month (6.9 vs. 6.2; P < 0.001), and a higher average EHRA score (2.6 vs. 2.4; P < 0.001). The duration of the procedure was shorter in females (160.1 min vs. 167.9 min; P < 0.001), irrespective of additional ablation lesions added to pulmonary vein isolation. Overall cardiovascular complications were more frequent in women than in men (5.7% vs. 3.4%; P < 0.001). Furthermore, cardiac perforations (3.8% vs. 1.3%; P = 0.011) and neurological complications (2.2% vs. 0.3%; P = 0.004) were found in females in less experienced centres than in experienced ones. On a final note, at 12 months, AF recurrence rate was similar in females and males (34.4% vs. 34.2%; P = 0.897), but more females were still on antiarrhythmic drugs (50.6% vs. 44.1%; P < 0.001) when compared with men.

Conclusion Females underwent CA procedures for AF less frequently than males throughout Europe, despite more recurrent symptoms. With the same success rate, severe acute complications remained considerable in females, especially in less experienced centres.},
  author       = {Grecu, Mihaela and Blomström-Lundqvist, Carina and Kautzner, Josef and Laroche, Cecile and Van Gelder, Isabelle C and Jordaens, Luc and Tavazzi, Luigi and Cihak, Robert and Rubio Campal, Jose Manuel and Kalarus, Zbigniew and Pokushalov, Evgeny and Brugada, Josep and Dagres, Nikolaos and Arbelo, Elena},
  issn         = {1099-5129},
  journal      = {EUROPACE},
  keywords     = {Atrial fibrillation,Catheter ablation,Sex differences,Gender differences,Registry,GENDER-RELATED DIFFERENCES,CATHETER ABLATION,EUROPEAN-SOCIETY,MANAGEMENT,EFFICACY,REGISTRY,SAFETY,HEART},
  language     = {eng},
  number       = {1},
  pages        = {66--73},
  title        = {In-hospital and 12-month follow-up outcome from the ESC-EORP EHRA Atrial Fibrillation Ablation Long-Term registry : sex differences},
  url          = {http://dx.doi.org/10.1093/europace/euz225},
  volume       = {22},
  year         = {2020},
}

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