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Experimental models to study intestinal microbes-mucus interactions in health and disease

(2019) FEMS MICROBIOLOGY REVIEWS. 43(5). p.457-489
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Abstract
close symbiotic relationship exists between the intestinal microbiota and its host. A critical component of gut homeostasis is the presence of a mucus layer covering the gastrointestinal tract. Mucus is a viscoelastic gel at the interface between the luminal content and the host tissue that provides a habitat to the gut microbiota and protects the intestinal epithelium. The review starts by setting up the biological context underpinning the need for experimental models to study gut bacteria-mucus interactions in the digestive environment. We provide an overview of the structure and function of intestinal mucus and mucins, their interactions with intestinal bacteria (including commensal, probiotics and pathogenic microorganisms) and their role in modulating health and disease states. We then describe the characteristics and potentials of experimental models currently available to study the mechanisms underpinning the interaction of mucus with gut microbes, including in vitro, ex vivo and in vivo models. We then discuss the limitations and challenges facing this field of research.
Keywords
intestinal mucus, gut microbiota, experimental models, mucin O-glycosylation, ENTEROHEMORRHAGIC ESCHERICHIA-COLI, LACTOBACILLUS-RHAMNOSUS GG, BACTERIAL MOONLIGHTING PROTEINS, ENTERICA SEROVAR TYPHIMURIUM, MEMBRANE-BOUND MUCINS, CELL-SURFACE MUCIN, DYNAMIC GUT MODEL, BLOOD-GROUP-A, IN-VITRO, HELICOBACTER-PYLORI

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MLA
Etienne-Mesmin, Lucie, et al. “Experimental Models to Study Intestinal Microbes-Mucus Interactions in Health and Disease.” FEMS MICROBIOLOGY REVIEWS, vol. 43, no. 5, 2019, pp. 457–89.
APA
Etienne-Mesmin, L., Chassaing, B., Desvaux, M., De Paepe, K., Gresse, R., Sauvaitre, T., … Blanquet-Diot, S. (2019). Experimental models to study intestinal microbes-mucus interactions in health and disease. FEMS MICROBIOLOGY REVIEWS, 43(5), 457–489.
Chicago author-date
Etienne-Mesmin, Lucie, Benoit Chassaing, Mickaël Desvaux, Kim De Paepe, Raphaële Gresse, Thomas Sauvaitre, Evelyne Forano, et al. 2019. “Experimental Models to Study Intestinal Microbes-Mucus Interactions in Health and Disease.” FEMS MICROBIOLOGY REVIEWS 43 (5): 457–89.
Chicago author-date (all authors)
Etienne-Mesmin, Lucie, Benoit Chassaing, Mickaël Desvaux, Kim De Paepe, Raphaële Gresse, Thomas Sauvaitre, Evelyne Forano, Tom Van de Wiele, Stephanie Schüller, Nathalie Juge, and Stéphanie Blanquet-Diot. 2019. “Experimental Models to Study Intestinal Microbes-Mucus Interactions in Health and Disease.” FEMS MICROBIOLOGY REVIEWS 43 (5): 457–489.
Vancouver
1.
Etienne-Mesmin L, Chassaing B, Desvaux M, De Paepe K, Gresse R, Sauvaitre T, et al. Experimental models to study intestinal microbes-mucus interactions in health and disease. FEMS MICROBIOLOGY REVIEWS. 2019;43(5):457–89.
IEEE
[1]
L. Etienne-Mesmin et al., “Experimental models to study intestinal microbes-mucus interactions in health and disease,” FEMS MICROBIOLOGY REVIEWS, vol. 43, no. 5, pp. 457–489, 2019.
@article{8625800,
  abstract     = { close symbiotic relationship exists between the intestinal microbiota and its host. A critical component of gut homeostasis is the presence of a mucus layer covering the gastrointestinal tract. Mucus is a viscoelastic gel at the interface between the luminal content and the host tissue that provides a habitat to the gut microbiota and protects the intestinal epithelium. The review starts by setting up the biological context underpinning the need for experimental models to study gut bacteria-mucus interactions in the digestive environment. We provide an overview of the structure and function of intestinal mucus and mucins, their interactions with intestinal bacteria (including commensal, probiotics and pathogenic microorganisms) and their role in modulating health and disease states. We then describe the characteristics and potentials of experimental models currently available to study the mechanisms underpinning the interaction of mucus with gut microbes, including in vitro, ex vivo and in vivo models. We then discuss the limitations and challenges facing this field of research.},
  author       = {Etienne-Mesmin, Lucie and Chassaing, Benoit and Desvaux, Mickaël and De Paepe, Kim and Gresse, Raphaële and Sauvaitre, Thomas and Forano, Evelyne and Van de Wiele, Tom and Schüller, Stephanie and Juge, Nathalie and Blanquet-Diot, Stéphanie},
  issn         = {0168-6445},
  journal      = {FEMS MICROBIOLOGY REVIEWS},
  keywords     = {intestinal mucus,gut microbiota,experimental models,mucin O-glycosylation,ENTEROHEMORRHAGIC ESCHERICHIA-COLI,LACTOBACILLUS-RHAMNOSUS GG,BACTERIAL MOONLIGHTING PROTEINS,ENTERICA SEROVAR TYPHIMURIUM,MEMBRANE-BOUND MUCINS,CELL-SURFACE MUCIN,DYNAMIC GUT MODEL,BLOOD-GROUP-A,IN-VITRO,HELICOBACTER-PYLORI},
  language     = {eng},
  number       = {5},
  pages        = {457--489},
  title        = {Experimental models to study intestinal microbes-mucus interactions in health and disease},
  url          = {http://dx.doi.org/10.1093/femsre/fuz013},
  volume       = {43},
  year         = {2019},
}

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