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Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain

Tjasa Lepko, Melanie Pusch, Tamara Mueller, Dorothea Schulte, Janina Ehses, Michael Kiebler, Julia Hasler, Hagen B. Huttner, Roosmarijn Vandenbroucke (UGent) , Charysse Vandendriessche (UGent) , et al.
(2019) EMBO JOURNAL. 38.
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Abstract
Regulation of adult neural stem cell (NSC) number is critical for lifelong neurogenesis. Here, we identified a post-transcriptional control mechanism, centered around the microRNA 204 (miR-204), to control the maintenance of quiescent (q)NSCs. miR-204 regulates a spectrum of transcripts involved in cell cycle regulation, neuronal migration, and differentiation in qNSCs. Importantly, inhibition of miR-204 function reduced the number of qNSCs in the subependymal zone (SEZ) by inducing pre-mature activation and differentiation of NSCs without changing their neurogenic potential. Strikingly, we identified the choroid plexus of the mouse lateral ventricle as the major source of miR-204 that is released into the cerebrospinal fluid to control number of NSCs within the SEZ. Taken together, our results describe a novel mechanism to maintain adult somatic stem cells by a niche-specific miRNA repressing activation and differentiation of stem cells.
Keywords
CEREBROSPINAL-FLUID, NEURONAL DIFFERENTIATION, SUBVENTRICULAR ZONE, PROGENITOR CELLS, FATE SPECIFICATION, EMBRYONIC ORIGIN, NEUROGENESIS, NICHE, MIGRATION, TRANSPLANTATION, adult neurogenesis, miR-204, neural stem cells, neurogenesis, neurogenic, priming

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MLA
Lepko, Tjasa, et al. “Choroid Plexus-Derived MiR-204 Regulates the Number of Quiescent Neural Stem Cells in the Adult Brain.” EMBO JOURNAL, vol. 38, 2019, doi:10.15252/embj.2018100481.
APA
Lepko, T., Pusch, M., Mueller, T., Schulte, D., Ehses, J., Kiebler, M., … Ninkovic, J. (2019). Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain. EMBO JOURNAL, 38. https://doi.org/10.15252/embj.2018100481
Chicago author-date
Lepko, Tjasa, Melanie Pusch, Tamara Mueller, Dorothea Schulte, Janina Ehses, Michael Kiebler, Julia Hasler, et al. 2019. “Choroid Plexus-Derived MiR-204 Regulates the Number of Quiescent Neural Stem Cells in the Adult Brain.” EMBO JOURNAL 38. https://doi.org/10.15252/embj.2018100481.
Chicago author-date (all authors)
Lepko, Tjasa, Melanie Pusch, Tamara Mueller, Dorothea Schulte, Janina Ehses, Michael Kiebler, Julia Hasler, Hagen B. Huttner, Roosmarijn Vandenbroucke, Charysse Vandendriessche, Miha Modic, Ana Martin-Villalba, Sheng Zhao, Enric LLorens-Bobadilla, Anja Schneider, Andre Fischer, Christopher T. Breunig, Stefan H. Stricker, Magdalena Goetz, and Jovica Ninkovic. 2019. “Choroid Plexus-Derived MiR-204 Regulates the Number of Quiescent Neural Stem Cells in the Adult Brain.” EMBO JOURNAL 38. doi:10.15252/embj.2018100481.
Vancouver
1.
Lepko T, Pusch M, Mueller T, Schulte D, Ehses J, Kiebler M, et al. Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain. EMBO JOURNAL. 2019;38.
IEEE
[1]
T. Lepko et al., “Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain,” EMBO JOURNAL, vol. 38, 2019.
@article{8625737,
  abstract     = {{Regulation of adult neural stem cell (NSC) number is critical for lifelong neurogenesis. Here, we identified a post-transcriptional control mechanism, centered around the microRNA 204 (miR-204), to control the maintenance of quiescent (q)NSCs. miR-204 regulates a spectrum of transcripts involved in cell cycle regulation, neuronal migration, and differentiation in qNSCs. Importantly, inhibition of miR-204 function reduced the number of qNSCs in the subependymal zone (SEZ) by inducing pre-mature activation and differentiation of NSCs without changing their neurogenic potential. Strikingly, we identified the choroid plexus of the mouse lateral ventricle as the major source of miR-204 that is released into the cerebrospinal fluid to control number of NSCs within the SEZ. Taken together, our results describe a novel mechanism to maintain adult somatic stem cells by a niche-specific miRNA repressing activation and differentiation of stem cells.}},
  articleno    = {{e100481}},
  author       = {{Lepko, Tjasa and Pusch, Melanie and Mueller, Tamara and Schulte, Dorothea and Ehses, Janina and Kiebler, Michael and Hasler, Julia and Huttner, Hagen B. and Vandenbroucke, Roosmarijn and Vandendriessche, Charysse and Modic, Miha and Martin-Villalba, Ana and Zhao, Sheng and LLorens-Bobadilla, Enric and Schneider, Anja and Fischer, Andre and Breunig, Christopher T. and Stricker, Stefan H. and Goetz, Magdalena and Ninkovic, Jovica}},
  issn         = {{0261-4189}},
  journal      = {{EMBO JOURNAL}},
  keywords     = {{CEREBROSPINAL-FLUID,NEURONAL DIFFERENTIATION,SUBVENTRICULAR ZONE,PROGENITOR CELLS,FATE SPECIFICATION,EMBRYONIC ORIGIN,NEUROGENESIS,NICHE,MIGRATION,TRANSPLANTATION,adult neurogenesis,miR-204,neural stem cells,neurogenesis,neurogenic,priming}},
  language     = {{eng}},
  pages        = {{18}},
  title        = {{Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain}},
  url          = {{http://dx.doi.org/10.15252/embj.2018100481}},
  volume       = {{38}},
  year         = {{2019}},
}
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