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Hippocampal activation during face-name associative memory encoding: blocked versus permuted design

Frederick De Vogelaere (UGent) , Patrick Santens (UGent) , Eric Achten (UGent) , Paul Boon (UGent) and Guy Vingerhoets (UGent)
(2010) NEURORADIOLOGY. 52(1). p.25-36
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Abstract
The contribution of the hippocampal subregions to episodic memory through the formation of new associations between previously unrelated items such as faces and names is established but remains under discussion. Block design studies in this area of research generally tend to show posterior hippocampal activation during encoding of novel associational material while event-related studies emphasize anterior hippocampal involvement. We used functional magnetic resonance imaging to assess the involvement of anterior and posterior hippocampus in the encoding of novel associational material compared to the viewing of previously seen associational material. We used two different experimental designs, a block design and a permuted block design, and applied it to the same associative memory task to perform valid statistical comparisons. Our results indicate that the permuted design was able to capture more anterior hippocampal activation compared to the block design, which emphasized more posterior hippocampal involvement. These differences were further investigated and attributed to a combination of the polymodal stimuli we used and the experimental design. Activation patterns during encoding in both designs occurred along the entire longitudinal axis of the hippocampus, but with different centers of gravity. The maximal activated voxel in the block design was situated in the posterior half of the hippocampus while in the permuted design this was located in the anterior half.
Keywords
POWER, CORTEX, EFFICIENCY, RECOGNITION, RETRIEVAL, BRAIN ACTIVITY, EVENT-RELATED FMRI, Hippocampus, DIFFERENTIATION, FUNCTIONAL MRI, Face-name association, Episodic memory, Anterior-posterior, fMRI, MEDIAL TEMPORAL-LOBE

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Chicago
De Vogelaere, Frederick, Patrick Santens, Eric Achten, Paul Boon, and Guy Vingerhoets. 2010. “Hippocampal Activation During Face-name Associative Memory Encoding: Blocked Versus Permuted Design.” Neuroradiology 52 (1): 25–36.
APA
De Vogelaere, F., Santens, P., Achten, E., Boon, P., & Vingerhoets, G. (2010). Hippocampal activation during face-name associative memory encoding: blocked versus permuted design. NEURORADIOLOGY, 52(1), 25–36.
Vancouver
1.
De Vogelaere F, Santens P, Achten E, Boon P, Vingerhoets G. Hippocampal activation during face-name associative memory encoding: blocked versus permuted design. NEURORADIOLOGY. 2010;52(1):25–36.
MLA
De Vogelaere, Frederick, Patrick Santens, Eric Achten, et al. “Hippocampal Activation During Face-name Associative Memory Encoding: Blocked Versus Permuted Design.” NEURORADIOLOGY 52.1 (2010): 25–36. Print.
@article{862571,
  abstract     = {The contribution of the hippocampal subregions to episodic memory through the formation of new associations between previously unrelated items such as faces and names is established but remains under discussion. Block design studies in this area of research generally tend to show posterior hippocampal activation during encoding of novel associational material while event-related studies emphasize anterior hippocampal involvement. We used functional magnetic resonance imaging to assess the involvement of anterior and posterior hippocampus in the encoding of novel associational material compared to the viewing of previously seen associational material.
We used two different experimental designs, a block design and a permuted block design, and applied it to the same associative memory task to perform valid statistical comparisons.
Our results indicate that the permuted design was able to capture more anterior hippocampal activation compared to the block design, which emphasized more posterior hippocampal involvement. These differences were further investigated and attributed to a combination of the polymodal stimuli we used and the experimental design.
Activation patterns during encoding in both designs occurred along the entire longitudinal axis of the hippocampus, but with different centers of gravity. The maximal activated voxel in the block design was situated in the posterior half of the hippocampus while in the permuted design this was located in the anterior half.},
  author       = {De Vogelaere, Frederick and Santens, Patrick and Achten, Eric and Boon, Paul and Vingerhoets, Guy},
  issn         = {0028-3940},
  journal      = {NEURORADIOLOGY},
  keyword      = {POWER,CORTEX,EFFICIENCY,RECOGNITION,RETRIEVAL,BRAIN ACTIVITY,EVENT-RELATED FMRI,Hippocampus,DIFFERENTIATION,FUNCTIONAL MRI,Face-name association,Episodic memory,Anterior-posterior,fMRI,MEDIAL TEMPORAL-LOBE},
  language     = {eng},
  number       = {1},
  pages        = {25--36},
  title        = {Hippocampal activation during face-name associative memory encoding: blocked versus permuted design},
  url          = {http://dx.doi.org/10.1007/s00234-009-0532-9},
  volume       = {52},
  year         = {2010},
}

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