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A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window

Zhiyue Zhang (UGent) , Hui Li (UGent) , Sabah Kasmi (UGent) , Simon Van Herck (UGent) , Kim Deswarte (UGent) , Bart Lambrecht (UGent) , Richard Hoogenboom (UGent) , Lutz Nuhn and Bruno De Geest (UGent)
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Abstract
Interactive materials that can respond to a trigger by changing their morphology, but that can also gradually degrade into a fully soluble state, are attractive building blocks for the next generation of biomaterials. Herein, we design such transiently responsive polymers that exhibit UCST behaviour while gradually losing this property in response to a hydrolysis reaction in the polymer side chains. The polymers operate within a physiologically relevant window in terms of temperature, pH, and ionic strength. Whereas such behaviour has been reported earlier for LCST systems, it is at present unexplored for UCST polymers. Furthermore, we demonstrate that, in contrast to LCST polymers, in aqueous medium the UCST polymer forms a coacervate phase below the UCST, which can entrap a hydrophilic model protein, as well as a hydrophobic dye. Because of their non-toxicity, we also provide invivo proof of concept of the use of this coacervate as a protein depot, in view of sustained-release applications.
Keywords
CRITICAL SOLUTION TEMPERATURE, STIMULI-RESPONSIVE POLYMERS, BLOCK-COPOLYMER MICELLES, RADICAL POLYMERIZATION, PHASE-TRANSITION, HPMA, COPOLYMERS, DRUG-DELIVERY, NANOPARTICLES, DESIGN, degradable polymers, gels, protein delivery, responsive polymers, UCST

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MLA
Zhang, Zhiyue et al. “A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour Within a Physiologically Relevant Window.” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.23 (2019): 7866–7872. Print.
APA
Zhang, Zhiyue, Li, H., Kasmi, S., Van Herck, S., Deswarte, K., Lambrecht, B., Hoogenboom, R., et al. (2019). A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58(23), 7866–7872.
Chicago author-date
Zhang, Zhiyue, Hui Li, Sabah Kasmi, Simon Van Herck, Kim Deswarte, Bart Lambrecht, Richard Hoogenboom, Lutz Nuhn, and Bruno De Geest. 2019. “A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour Within a Physiologically Relevant Window.” Angewandte Chemie-international Edition 58 (23): 7866–7872.
Chicago author-date (all authors)
Zhang, Zhiyue, Hui Li, Sabah Kasmi, Simon Van Herck, Kim Deswarte, Bart Lambrecht, Richard Hoogenboom, Lutz Nuhn, and Bruno De Geest. 2019. “A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour Within a Physiologically Relevant Window.” Angewandte Chemie-international Edition 58 (23): 7866–7872.
Vancouver
1.
Zhang Z, Li H, Kasmi S, Van Herck S, Deswarte K, Lambrecht B, et al. A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. WILEY-V C H VERLAG ; 2019;58(23):7866–72.
IEEE
[1]
Z. Zhang et al., “A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window,” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 58, no. 23, pp. 7866–7872, 2019.
@article{8625676,
  abstract     = {Interactive materials that can respond to a trigger by changing their morphology, but that can also gradually degrade into a fully soluble state, are attractive building blocks for the next generation of biomaterials. Herein, we design such transiently responsive polymers that exhibit UCST behaviour while gradually losing this property in response to a hydrolysis reaction in the polymer side chains. The polymers operate within a physiologically relevant window in terms of temperature, pH, and ionic strength. Whereas such behaviour has been reported earlier for LCST systems, it is at present unexplored for UCST polymers. Furthermore, we demonstrate that, in contrast to LCST polymers, in aqueous medium the UCST polymer forms a coacervate phase below the UCST, which can entrap a hydrophilic model protein, as well as a hydrophobic dye. Because of their non-toxicity, we also provide invivo proof of concept of the use of this coacervate as a protein depot, in view of sustained-release applications.},
  author       = {Zhang, Zhiyue and Li, Hui and Kasmi, Sabah and Van Herck, Simon and Deswarte, Kim and Lambrecht, Bart and Hoogenboom, Richard and Nuhn, Lutz and De Geest, Bruno},
  issn         = {1433-7851},
  journal      = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},
  keywords     = {CRITICAL SOLUTION TEMPERATURE,STIMULI-RESPONSIVE POLYMERS,BLOCK-COPOLYMER MICELLES,RADICAL POLYMERIZATION,PHASE-TRANSITION,HPMA,COPOLYMERS,DRUG-DELIVERY,NANOPARTICLES,DESIGN,degradable polymers,gels,protein delivery,responsive polymers,UCST},
  language     = {eng},
  number       = {23},
  pages        = {7866--7872},
  publisher    = {WILEY-V C H VERLAG },
  title        = {A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window},
  url          = {http://dx.doi.org/10.1002/anie.201900224},
  volume       = {58},
  year         = {2019},
}

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