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Antimicrobial tolerance and metabolic adaptations in microbial biofilms

(2019) TRENDS IN MICROBIOLOGY. 27(10). p.850-863
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Abstract
Active bacterial metabolism is a prerequisite for optimal activity of many classes of antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic pathways to become tolerant. This review describes the tight relationship between metabolism and tolerance in bacterial biofilms, and how physicochemical properties of the microenvironment at the host-pathogen interface (such as oxygen and nutritional content) are key to this relationship. Understanding how metabolic adaptations lead to tolerance brings us to novel approaches to tackle antibiotic-tolerant biofilms. We describe the use of hyperbaric oxygen therapy, metabolism-stimulating metabolites, and alternative strategies to redirect bacterial metabolism towards an antibiotic-susceptible phenotype.
Keywords
PSEUDOMONAS-AERUGINOSA BIOFILMS, HYPERBARIC-OXYGEN THERAPY, POLYMORPHONUCLEAR LEUKOCYTES, ANTIBIOTIC-TREATMENT, BACTERIAL BIOFILMS, GENE-EXPRESSION, TREATMENT LEADS, IN-VITRO, RESISTANCE, SUSCEPTIBILITY

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Citation

Please use this url to cite or link to this publication:

MLA
Crabbé, Aurélie, et al. “Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms.” TRENDS IN MICROBIOLOGY, vol. 27, no. 10, 2019, pp. 850–63.
APA
Crabbé, A., Jensen, P. Ø., Bjarnsholt, T., & Coenye, T. (2019). Antimicrobial tolerance and metabolic adaptations in microbial biofilms. TRENDS IN MICROBIOLOGY, 27(10), 850–863.
Chicago author-date
Crabbé, Aurélie, Peter Østrup Jensen, Thomas Bjarnsholt, and Tom Coenye. 2019. “Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms.” TRENDS IN MICROBIOLOGY 27 (10): 850–63.
Chicago author-date (all authors)
Crabbé, Aurélie, Peter Østrup Jensen, Thomas Bjarnsholt, and Tom Coenye. 2019. “Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms.” TRENDS IN MICROBIOLOGY 27 (10): 850–863.
Vancouver
1.
Crabbé A, Jensen PØ, Bjarnsholt T, Coenye T. Antimicrobial tolerance and metabolic adaptations in microbial biofilms. TRENDS IN MICROBIOLOGY. 2019;27(10):850–63.
IEEE
[1]
A. Crabbé, P. Ø. Jensen, T. Bjarnsholt, and T. Coenye, “Antimicrobial tolerance and metabolic adaptations in microbial biofilms,” TRENDS IN MICROBIOLOGY, vol. 27, no. 10, pp. 850–863, 2019.
@article{8625280,
  abstract     = {Active bacterial metabolism is a prerequisite for optimal activity of many classes of antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic pathways to become tolerant. This review describes the tight relationship between metabolism and tolerance in bacterial biofilms, and how physicochemical properties of the microenvironment at the host-pathogen interface (such as oxygen and nutritional content) are key to this relationship. Understanding how metabolic adaptations lead to tolerance brings us to novel approaches to tackle antibiotic-tolerant biofilms. We describe the use of hyperbaric oxygen therapy, metabolism-stimulating metabolites, and alternative strategies to redirect bacterial metabolism towards an antibiotic-susceptible phenotype.},
  author       = {Crabbé, Aurélie and Jensen, Peter Østrup and Bjarnsholt, Thomas and Coenye, Tom},
  issn         = {0966-842X},
  journal      = {TRENDS IN MICROBIOLOGY},
  keywords     = {PSEUDOMONAS-AERUGINOSA BIOFILMS,HYPERBARIC-OXYGEN THERAPY,POLYMORPHONUCLEAR LEUKOCYTES,ANTIBIOTIC-TREATMENT,BACTERIAL BIOFILMS,GENE-EXPRESSION,TREATMENT LEADS,IN-VITRO,RESISTANCE,SUSCEPTIBILITY},
  language     = {eng},
  number       = {10},
  pages        = {850--863},
  title        = {Antimicrobial tolerance and metabolic adaptations in microbial biofilms},
  url          = {http://dx.doi.org/10.1016/j.tim.2019.05.003},
  volume       = {27},
  year         = {2019},
}

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