@inproceedings{8625065,
  abstract     = {Over the past few decades, copepods have gained considerable popularity as test
organisms in ecotoxicological studies. This is mainly due to their key role in freshwater
and marine ecosystems. Harpacticoid copepods like the euryhaline brackish water
species Nitocra spinipes, for instance, form an important link between the
microphytobenthos and organisms of higher trophic levels. N. spinipes has been
extensively used in ecotoxicity testing since the 1970s. An acute toxicity test and a
larval development test with N. spinipes have been established under ISO.
Furthermore, the OECD released a guidance document for a development and
reproduction test with the harpacticoid copepod Amphiascus tenuiremis for which it
recommends N. spinipes as an alternative test species. To date, there is a wealth of
available life history data on this species under controlled conditions in the presence
and absence of chemical stressors. However, while thus far adverse effects on
different history traits have mostly been evaluated independently, it is our aim to
investigate the underlying modes of action (MoAs), which lead to specific
combinations of effects in N. spinipes. To investigate such MoAs on the level of energy
uptake and allocation within N. spinipes, we made use of the dynamic energy budget
theory (DEB) framework. In an individual based modelling approach (IBM) the DEBkiss
(‘keep it simple, stupid’) model structure was used to build a mechanistic population
model for N. spinipes. Small modifications to the generic model structure were made
to account for specific peculiarities in the copepod life cycle. These include a change
in shape in the course of an individual copepod’s development, as well as an abrupt
stop in growth after reaching the adult stage. We used the selective serotonin
reuptake inhibitor citalopram as a model anthropogenic stressor to assess. Effects on
the development time, adult body length, brood size, brood-to-brood development
time, mortality and sex ratio of N. spinipes were measured experimentally and
evaluated in terms of their MoAs.},
  author       = {Koch, Josef and Janssen, Colin and De Schamphelaere, Karel},
  language     = {eng},
  location     = {Tromsø},
  title        = {Harpacticoid copepods in a DEB framework: Investigating pharmaceutical effects on Nitocra spinipes},
  year         = {2017},
}