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Exploratory relationships between cognitive improvements and training induced plasticity in hippocampus and cingulum in a rat model of mild traumatic brain injury : a diffusion MRI study

(2020) BRAIN IMAGING AND BEHAVIOR. 14(6). p.2281-2294
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Abstract
Traumatic brain injury (TBI) is a major cause of long-term cognitive deficits, even in mild TBI patients. Computerized cognitive training can help alleviate complaints and improve daily life functioning of TBI patients. However, the underlying biological mechanisms of cognitive training in TBI are not fully understood. In the present study, we utilised for the first time a touchscreen cognitive training system in a rat model of mild TBI. Moreover, we wanted to examine whether the beneficial effects of a cognitive training are task-dependent and selective in their target. Specifically, we examined the effect of two training tasks, i.e. the Paired Associate Learning (PAL) task targeting spatial memory functioning and 5-Choice Continuous Performance (5-CCP) task loading on attention and inhibition control, on the microstructural organization of the hippocampus and cingulum, respectively, using diffusion tensor imaging (DTI). Our findings revealed that the two training protocols induced similar effects on the diffusion MRI metrics. Further, in the TBI groups who received training microstructural organization in the hippocampus and cingulum improved (as denoted by increases in fractional anisotropy), while a worsening (i.e., increases in mean diffusivity and radial diffusivity) was found in the TBI control group. In addition, these alterations in diffusion MRI metrics coincided with improved performance on the training tasks in the TBI groups who received training. Our findings show the potential of DTI metrics as reliable measure to evaluate cognitive training in TBI patients and to facilitate future research investigating further improvement of cognitive training targeting deficits in spatial memory and attention.
Keywords
Cognitive Neuroscience, Behavioral Neuroscience, Radiology Nuclear Medicine and imaging, Cellular and Molecular Neuroscience, Neurology, Psychiatry and Mental health, Clinical Neurology, Mild traumatic brain injury, Diffusion MRI, Touchscreen cognitive training system, Neuroplasticity, Preclinical, REACTION-TIME-TASK, WHITE-MATTER MICROSTRUCTURE, LEARNING PAL TASK, TRANSLATIONAL ASSAYS, EXECUTIVE FUNCTION, TESTING METHOD, RODENT MODEL, REHABILITATION, MEMORY, ATTENTION

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MLA
Braeckman, Kim, et al. “Exploratory Relationships between Cognitive Improvements and Training Induced Plasticity in Hippocampus and Cingulum in a Rat Model of Mild Traumatic Brain Injury : A Diffusion MRI Study.” BRAIN IMAGING AND BEHAVIOR, vol. 14, no. 6, 2020, pp. 2281–94, doi:10.1007/s11682-019-00179-4.
APA
Braeckman, K., Descamps, B., Vanhove, C., & Caeyenberghs, K. (2020). Exploratory relationships between cognitive improvements and training induced plasticity in hippocampus and cingulum in a rat model of mild traumatic brain injury : a diffusion MRI study. BRAIN IMAGING AND BEHAVIOR, 14(6), 2281–2294. https://doi.org/10.1007/s11682-019-00179-4
Chicago author-date
Braeckman, Kim, Benedicte Descamps, Christian Vanhove, and Karen Caeyenberghs. 2020. “Exploratory Relationships between Cognitive Improvements and Training Induced Plasticity in Hippocampus and Cingulum in a Rat Model of Mild Traumatic Brain Injury : A Diffusion MRI Study.” BRAIN IMAGING AND BEHAVIOR 14 (6): 2281–94. https://doi.org/10.1007/s11682-019-00179-4.
Chicago author-date (all authors)
Braeckman, Kim, Benedicte Descamps, Christian Vanhove, and Karen Caeyenberghs. 2020. “Exploratory Relationships between Cognitive Improvements and Training Induced Plasticity in Hippocampus and Cingulum in a Rat Model of Mild Traumatic Brain Injury : A Diffusion MRI Study.” BRAIN IMAGING AND BEHAVIOR 14 (6): 2281–2294. doi:10.1007/s11682-019-00179-4.
Vancouver
1.
Braeckman K, Descamps B, Vanhove C, Caeyenberghs K. Exploratory relationships between cognitive improvements and training induced plasticity in hippocampus and cingulum in a rat model of mild traumatic brain injury : a diffusion MRI study. BRAIN IMAGING AND BEHAVIOR. 2020;14(6):2281–94.
IEEE
[1]
K. Braeckman, B. Descamps, C. Vanhove, and K. Caeyenberghs, “Exploratory relationships between cognitive improvements and training induced plasticity in hippocampus and cingulum in a rat model of mild traumatic brain injury : a diffusion MRI study,” BRAIN IMAGING AND BEHAVIOR, vol. 14, no. 6, pp. 2281–2294, 2020.
@article{8624997,
  abstract     = {{Traumatic brain injury (TBI) is a major cause of long-term cognitive deficits, even in mild TBI patients. Computerized cognitive training can help alleviate complaints and improve daily life functioning of TBI patients. However, the underlying biological mechanisms of cognitive training in TBI are not fully understood. In the present study, we utilised for the first time a touchscreen cognitive training system in a rat model of mild TBI. Moreover, we wanted to examine whether the beneficial effects of a cognitive training are task-dependent and selective in their target. Specifically, we examined the effect of two training tasks, i.e. the Paired Associate Learning (PAL) task targeting spatial memory functioning and 5-Choice Continuous Performance (5-CCP) task loading on attention and inhibition control, on the microstructural organization of the hippocampus and cingulum, respectively, using diffusion tensor imaging (DTI). Our findings revealed that the two training protocols induced similar effects on the diffusion MRI metrics. Further, in the TBI groups who received training microstructural organization in the hippocampus and cingulum improved (as denoted by increases in fractional anisotropy), while a worsening (i.e., increases in mean diffusivity and radial diffusivity) was found in the TBI control group. In addition, these alterations in diffusion MRI metrics coincided with improved performance on the training tasks in the TBI groups who received training. Our findings show the potential of DTI metrics as reliable measure to evaluate cognitive training in TBI patients and to facilitate future research investigating further improvement of cognitive training targeting deficits in spatial memory and attention.}},
  author       = {{Braeckman, Kim and Descamps, Benedicte and Vanhove, Christian and Caeyenberghs, Karen}},
  issn         = {{1931-7557}},
  journal      = {{BRAIN IMAGING AND BEHAVIOR}},
  keywords     = {{Cognitive Neuroscience,Behavioral Neuroscience,Radiology Nuclear Medicine and imaging,Cellular and Molecular Neuroscience,Neurology,Psychiatry and Mental health,Clinical Neurology,Mild traumatic brain injury,Diffusion MRI,Touchscreen cognitive training system,Neuroplasticity,Preclinical,REACTION-TIME-TASK,WHITE-MATTER MICROSTRUCTURE,LEARNING PAL TASK,TRANSLATIONAL ASSAYS,EXECUTIVE FUNCTION,TESTING METHOD,RODENT MODEL,REHABILITATION,MEMORY,ATTENTION}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{2281--2294}},
  title        = {{Exploratory relationships between cognitive improvements and training induced plasticity in hippocampus and cingulum in a rat model of mild traumatic brain injury : a diffusion MRI study}},
  url          = {{http://dx.doi.org/10.1007/s11682-019-00179-4}},
  volume       = {{14}},
  year         = {{2020}},
}

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