
Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus)
- Author
- Ilse Moeremans (UGent) , Mathias Devreese (UGent) , Siegrid De Baere (UGent) , Siska Croubels (UGent) and Katleen Hermans (UGent)
- Organization
- Abstract
- Objective: To investigate the pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs. Study design: Prospective crossover study. Animals: A group of six healthy male Dunkin Hartley guinea pigs. Methods: A single dose of meloxicam (1.5 mg kg(-1)) was administered orally and intravenously (IV) to six healthy male guinea pigs. A wash-out period of 48 hours was taken into account between administrations (oral and IV) in the same animal. Blood was sampled through a central venous catheter before administration (t = 0 hours) and at 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 16, 20, 24 and 28 hours post administration. After centrifugation, plasma concentrations of meloxicam were measured by high-performance liquid chromatography with UV detection, and pharmacokinetic parameters were calculated using noncompartmental analysis. Results: Meloxicam in guinea pigs exhibited a moderate absorption rate after oral dosing (time to maximal plasma concentration 3.7 +/- 1.7 hours) and maximal plasma concentration was 0.92 +/- 0.30 mg mL(-1). After IV administration, total body clearance and volume of distribution were 0.13 +/- 0.04 and 0.72 +/- 0.36 L kg(-1), respectively. Terminal half-life was 3.7 +/- 0.7 hours and 3.5 +/- 1.1 hours after IV and oral administration, respectively. Body extraction ratio was 0.0087 and mean absorption time was 3.8 +/- 1.7 hours. The absolute oral bioavailability was 0.54 +/- 0.14 in unfasted guinea pigs. Conclusions and clinical relevance: This study reported the pharmacokinetics of meloxicam in guinea pigs. Studies concerning efficacy and safety are the next step towards a rational use of this drug in guinea pigs.
- Keywords
- bioavailability, Cavia porcellus, guinea pig, meloxicam, nonsteroidal anti-inflammatory drug, pharmacokinetics, CYCLOOXYGENASE INHIBITORS, SINGLE, RABBITS, HORSES, PHARMACODYNAMICS, SELECTIVITY, FLUNIXIN, BLOOD, GOATS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8624649
- MLA
- Moeremans, Ilse, et al. “Pharmacokinetics and Absolute Oral Bioavailability of Meloxicam in Guinea Pigs (Cavia Porcellus).” VETERINARY ANAESTHESIA AND ANALGESIA, vol. 46, no. 4, 2019, pp. 548–55, doi:10.1016/j.vaa.2018.11.011.
- APA
- Moeremans, I., Devreese, M., De Baere, S., Croubels, S., & Hermans, K. (2019). Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus). VETERINARY ANAESTHESIA AND ANALGESIA, 46(4), 548–555. https://doi.org/10.1016/j.vaa.2018.11.011
- Chicago author-date
- Moeremans, Ilse, Mathias Devreese, Siegrid De Baere, Siska Croubels, and Katleen Hermans. 2019. “Pharmacokinetics and Absolute Oral Bioavailability of Meloxicam in Guinea Pigs (Cavia Porcellus).” VETERINARY ANAESTHESIA AND ANALGESIA 46 (4): 548–55. https://doi.org/10.1016/j.vaa.2018.11.011.
- Chicago author-date (all authors)
- Moeremans, Ilse, Mathias Devreese, Siegrid De Baere, Siska Croubels, and Katleen Hermans. 2019. “Pharmacokinetics and Absolute Oral Bioavailability of Meloxicam in Guinea Pigs (Cavia Porcellus).” VETERINARY ANAESTHESIA AND ANALGESIA 46 (4): 548–555. doi:10.1016/j.vaa.2018.11.011.
- Vancouver
- 1.Moeremans I, Devreese M, De Baere S, Croubels S, Hermans K. Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus). VETERINARY ANAESTHESIA AND ANALGESIA. 2019;46(4):548–55.
- IEEE
- [1]I. Moeremans, M. Devreese, S. De Baere, S. Croubels, and K. Hermans, “Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus),” VETERINARY ANAESTHESIA AND ANALGESIA, vol. 46, no. 4, pp. 548–555, 2019.
@article{8624649, abstract = {{Objective: To investigate the pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs. Study design: Prospective crossover study. Animals: A group of six healthy male Dunkin Hartley guinea pigs. Methods: A single dose of meloxicam (1.5 mg kg(-1)) was administered orally and intravenously (IV) to six healthy male guinea pigs. A wash-out period of 48 hours was taken into account between administrations (oral and IV) in the same animal. Blood was sampled through a central venous catheter before administration (t = 0 hours) and at 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 16, 20, 24 and 28 hours post administration. After centrifugation, plasma concentrations of meloxicam were measured by high-performance liquid chromatography with UV detection, and pharmacokinetic parameters were calculated using noncompartmental analysis. Results: Meloxicam in guinea pigs exhibited a moderate absorption rate after oral dosing (time to maximal plasma concentration 3.7 +/- 1.7 hours) and maximal plasma concentration was 0.92 +/- 0.30 mg mL(-1). After IV administration, total body clearance and volume of distribution were 0.13 +/- 0.04 and 0.72 +/- 0.36 L kg(-1), respectively. Terminal half-life was 3.7 +/- 0.7 hours and 3.5 +/- 1.1 hours after IV and oral administration, respectively. Body extraction ratio was 0.0087 and mean absorption time was 3.8 +/- 1.7 hours. The absolute oral bioavailability was 0.54 +/- 0.14 in unfasted guinea pigs. Conclusions and clinical relevance: This study reported the pharmacokinetics of meloxicam in guinea pigs. Studies concerning efficacy and safety are the next step towards a rational use of this drug in guinea pigs.}}, author = {{Moeremans, Ilse and Devreese, Mathias and De Baere, Siegrid and Croubels, Siska and Hermans, Katleen}}, issn = {{1467-2987}}, journal = {{VETERINARY ANAESTHESIA AND ANALGESIA}}, keywords = {{bioavailability,Cavia porcellus,guinea pig,meloxicam,nonsteroidal anti-inflammatory drug,pharmacokinetics,CYCLOOXYGENASE INHIBITORS,SINGLE,RABBITS,HORSES,PHARMACODYNAMICS,SELECTIVITY,FLUNIXIN,BLOOD,GOATS}}, language = {{eng}}, number = {{4}}, pages = {{548--555}}, title = {{Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus)}}, url = {{http://dx.doi.org/10.1016/j.vaa.2018.11.011}}, volume = {{46}}, year = {{2019}}, }
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