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Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus)

Ilse Moeremans (UGent) , Mathias Devreese (UGent) , Siegrid De Baere (UGent) , Siska Croubels (UGent) and Katleen Hermans (UGent)
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Abstract
Objective: To investigate the pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs. Study design: Prospective crossover study. Animals: A group of six healthy male Dunkin Hartley guinea pigs. Methods: A single dose of meloxicam (1.5 mg kg(-1)) was administered orally and intravenously (IV) to six healthy male guinea pigs. A wash-out period of 48 hours was taken into account between administrations (oral and IV) in the same animal. Blood was sampled through a central venous catheter before administration (t = 0 hours) and at 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 16, 20, 24 and 28 hours post administration. After centrifugation, plasma concentrations of meloxicam were measured by high-performance liquid chromatography with UV detection, and pharmacokinetic parameters were calculated using noncompartmental analysis. Results: Meloxicam in guinea pigs exhibited a moderate absorption rate after oral dosing (time to maximal plasma concentration 3.7 +/- 1.7 hours) and maximal plasma concentration was 0.92 +/- 0.30 mg mL(-1). After IV administration, total body clearance and volume of distribution were 0.13 +/- 0.04 and 0.72 +/- 0.36 L kg(-1), respectively. Terminal half-life was 3.7 +/- 0.7 hours and 3.5 +/- 1.1 hours after IV and oral administration, respectively. Body extraction ratio was 0.0087 and mean absorption time was 3.8 +/- 1.7 hours. The absolute oral bioavailability was 0.54 +/- 0.14 in unfasted guinea pigs. Conclusions and clinical relevance: This study reported the pharmacokinetics of meloxicam in guinea pigs. Studies concerning efficacy and safety are the next step towards a rational use of this drug in guinea pigs.
Keywords
bioavailability, Cavia porcellus, guinea pig, meloxicam, nonsteroidal anti-inflammatory drug, pharmacokinetics, CYCLOOXYGENASE INHIBITORS, SINGLE, RABBITS, HORSES, PHARMACODYNAMICS, SELECTIVITY, FLUNIXIN, BLOOD, GOATS

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MLA
Moeremans, Ilse, et al. “Pharmacokinetics and Absolute Oral Bioavailability of Meloxicam in Guinea Pigs (Cavia Porcellus).” VETERINARY ANAESTHESIA AND ANALGESIA, vol. 46, no. 4, 2019, pp. 548–55.
APA
Moeremans, I., Devreese, M., De Baere, S., Croubels, S., & Hermans, K. (2019). Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus). VETERINARY ANAESTHESIA AND ANALGESIA, 46(4), 548–555.
Chicago author-date
Moeremans, Ilse, Mathias Devreese, Siegrid De Baere, Siska Croubels, and Katleen Hermans. 2019. “Pharmacokinetics and Absolute Oral Bioavailability of Meloxicam in Guinea Pigs (Cavia Porcellus).” VETERINARY ANAESTHESIA AND ANALGESIA 46 (4): 548–55.
Chicago author-date (all authors)
Moeremans, Ilse, Mathias Devreese, Siegrid De Baere, Siska Croubels, and Katleen Hermans. 2019. “Pharmacokinetics and Absolute Oral Bioavailability of Meloxicam in Guinea Pigs (Cavia Porcellus).” VETERINARY ANAESTHESIA AND ANALGESIA 46 (4): 548–555.
Vancouver
1.
Moeremans I, Devreese M, De Baere S, Croubels S, Hermans K. Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus). VETERINARY ANAESTHESIA AND ANALGESIA. 2019;46(4):548–55.
IEEE
[1]
I. Moeremans, M. Devreese, S. De Baere, S. Croubels, and K. Hermans, “Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus),” VETERINARY ANAESTHESIA AND ANALGESIA, vol. 46, no. 4, pp. 548–555, 2019.
@article{8624649,
  abstract     = {Objective: To investigate the pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs. 
Study design: Prospective crossover study. 
Animals: A group of six healthy male Dunkin Hartley guinea pigs. 
Methods: A single dose of meloxicam (1.5 mg kg(-1)) was administered orally and intravenously (IV) to six healthy male guinea pigs. A wash-out period of 48 hours was taken into account between administrations (oral and IV) in the same animal. Blood was sampled through a central venous catheter before administration (t = 0 hours) and at 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 16, 20, 24 and 28 hours post administration. After centrifugation, plasma concentrations of meloxicam were measured by high-performance liquid chromatography with UV detection, and pharmacokinetic parameters were calculated using noncompartmental analysis. 
Results: Meloxicam in guinea pigs exhibited a moderate absorption rate after oral dosing (time to maximal plasma concentration 3.7 +/- 1.7 hours) and maximal plasma concentration was 0.92 +/- 0.30 mg mL(-1). After IV administration, total body clearance and volume of distribution were 0.13 +/- 0.04 and 0.72 +/- 0.36 L kg(-1), respectively. Terminal half-life was 3.7 +/- 0.7 hours and 3.5 +/- 1.1 hours after IV and oral administration, respectively. Body extraction ratio was 0.0087 and mean absorption time was 3.8 +/- 1.7 hours. The absolute oral bioavailability was 0.54 +/- 0.14 in unfasted guinea pigs. 
Conclusions and clinical relevance: This study reported the pharmacokinetics of meloxicam in guinea pigs. Studies concerning efficacy and safety are the next step towards a rational use of this drug in guinea pigs.},
  author       = {Moeremans, Ilse and Devreese, Mathias and De Baere, Siegrid and Croubels, Siska and Hermans, Katleen},
  issn         = {1467-2987},
  journal      = {VETERINARY ANAESTHESIA AND ANALGESIA},
  keywords     = {bioavailability,Cavia porcellus,guinea pig,meloxicam,nonsteroidal anti-inflammatory drug,pharmacokinetics,CYCLOOXYGENASE INHIBITORS,SINGLE,RABBITS,HORSES,PHARMACODYNAMICS,SELECTIVITY,FLUNIXIN,BLOOD,GOATS},
  language     = {eng},
  number       = {4},
  pages        = {548--555},
  title        = {Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus)},
  url          = {http://dx.doi.org/10.1016/j.vaa.2018.11.011},
  volume       = {46},
  year         = {2019},
}

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