Advanced search
1 file | 515.13 KB Add to list

Selenoprotein P and its potential role in Alzheimer's disease

Author
Organization
Abstract
Alzheimer's disease (AD) is the most common neurodegenerative disease associated with cognitive decline, loss of memory, and progressive cerebral atrophy. The trace element selenium (Se) is known to be involved in brain pathology. Selenoprotein P (SELENOP), as the main Se transport protein, is, to a great extent, responsible for maintaining Se homeostasis and the hierarchy of selenoprotein expression in the body. Adequate Se supply through SELENOP is vital for proper brain development and function. Additionally, SELENOP may be implicated in pathological processes in the central nervous system, including those in AD. The current review summarizes recent findings on the possible role of SELENOP in AD, with a focus on probable mechanisms: Se delivery to neurons, antioxidant activity, cytoskeleton assembly, interaction with redox-active metals (e.g., copper and iron), and misfolded proteins (amyloid beta and tau protein). The use of SELENOP as a biomarker of Se status is also briefly discussed. Epidemiological studies on Se supplementation are beyond the scope of the current review.
Keywords
Alzheimer's disease, Selenium, Selenoprotein P, Brain, Oxidative stress, Redox regulation, Biomarkers, Trace elements, CEREBROSPINAL-FLUID, SELENIUM LEVELS, BRAIN IMPLICATIONS, OXIDATIVE STRESS, EXPRESSION, MICE, COPPER, IRON, NEURODEGENERATION, AGGREGATION

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 515.13 KB

Citation

Please use this url to cite or link to this publication:

MLA
Solovyev, Nikolay. “Selenoprotein P and Its Potential Role in Alzheimer’s Disease.” HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, vol. 19, no. 1, 2020, pp. 73–79, doi:10.1007/s42000-019-00112-w.
APA
Solovyev, N. (2020). Selenoprotein P and its potential role in Alzheimer’s disease. HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 19(1), 73–79. https://doi.org/10.1007/s42000-019-00112-w
Chicago author-date
Solovyev, Nikolay. 2020. “Selenoprotein P and Its Potential Role in Alzheimer’s Disease.” HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM 19 (1): 73–79. https://doi.org/10.1007/s42000-019-00112-w.
Chicago author-date (all authors)
Solovyev, Nikolay. 2020. “Selenoprotein P and Its Potential Role in Alzheimer’s Disease.” HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM 19 (1): 73–79. doi:10.1007/s42000-019-00112-w.
Vancouver
1.
Solovyev N. Selenoprotein P and its potential role in Alzheimer’s disease. HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM. 2020;19(1):73–9.
IEEE
[1]
N. Solovyev, “Selenoprotein P and its potential role in Alzheimer’s disease,” HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, vol. 19, no. 1, pp. 73–79, 2020.
@article{8624271,
  abstract     = {{Alzheimer's disease (AD) is the most common neurodegenerative disease associated with cognitive decline, loss of memory, and progressive cerebral atrophy. The trace element selenium (Se) is known to be involved in brain pathology. Selenoprotein P (SELENOP), as the main Se transport protein, is, to a great extent, responsible for maintaining Se homeostasis and the hierarchy of selenoprotein expression in the body. Adequate Se supply through SELENOP is vital for proper brain development and function. Additionally, SELENOP may be implicated in pathological processes in the central nervous system, including those in AD. The current review summarizes recent findings on the possible role of SELENOP in AD, with a focus on probable mechanisms: Se delivery to neurons, antioxidant activity, cytoskeleton assembly, interaction with redox-active metals (e.g., copper and iron), and misfolded proteins (amyloid beta and tau protein). The use of SELENOP as a biomarker of Se status is also briefly discussed. Epidemiological studies on Se supplementation are beyond the scope of the current review.}},
  author       = {{Solovyev, Nikolay}},
  issn         = {{1109-3099}},
  journal      = {{HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM}},
  keywords     = {{Alzheimer's disease,Selenium,Selenoprotein P,Brain,Oxidative stress,Redox regulation,Biomarkers,Trace elements,CEREBROSPINAL-FLUID,SELENIUM LEVELS,BRAIN IMPLICATIONS,OXIDATIVE STRESS,EXPRESSION,MICE,COPPER,IRON,NEURODEGENERATION,AGGREGATION}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{73--79}},
  title        = {{Selenoprotein P and its potential role in Alzheimer's disease}},
  url          = {{http://dx.doi.org/10.1007/s42000-019-00112-w}},
  volume       = {{19}},
  year         = {{2020}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: