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Type-Specific Human Papillomavirus Prevalence, Incident Cases, Persistence, and Associated Pregnancy Outcomes Among HIV-Infected Women in Kenya

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Abstract
BACKGROUND: Persistent infection with high-risk types of human papillomavirus (HPV) is the preeminent factor driving the development of cervical cancer. There are large gaps in knowledge about both the role of pregnancy in the natural history of HPV infection and the impact of HPV on pregnancy outcomes. METHODS: This single-site prospective cohort substudy, nested within an international multisite randomized controlled trial, assessed prevalence, incident cases, and persistence of type-specific HPV infection, and the association between persistence of high-risk HPV infection with pregnancy outcomes among HIV-infected pregnant women in Kenya, including HIV transmission to infants. Type-specific HPV was assessed using a line probe assay in pregnancy and again at 3 months after delivery. HIV status of children was determined using polymerase chain reaction at 6 weeks. RESULTS: In total, 84.1% (206/245) of women had a high-risk HPV infection at enrollment. Three quarters (157/206) of these infections persisted postpartum. Persistence of HPV16 and/or HPV18 types was observed in more than half (53.4%; 39/73) of women with this infection at enrollment. Almost two-thirds had an incident high-risk HPV infection postpartum, which was not present in pregnancy (62.5%), most commonly HPV52 (19.0%). After adjustments, no association was detected between persistent high-risk HPV and preterm birth. All mothers of the 7 cases of infant HIV infection had persistent high-risk HPV infection (P = 0.044). CONCLUSIONS: High levels of high-risk HPV infection and type-specific persistence were documented, heightening the urgency of mass role out of HPV vaccination. The association between HPV persistence and HIV transmission is a novel finding, warranting further study.
Keywords
Public Health, Environmental and Occupational Health, Microbiology (medical), Infectious Diseases, Dermatology

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MLA
Vyankandondera, Joseph et al. “Type-Specific Human Papillomavirus Prevalence, Incident Cases, Persistence, and Associated Pregnancy Outcomes Among HIV-Infected Women in Kenya.” Sexually Transmitted Diseases (2019): 532–539. Print.
APA
Vyankandondera, J., Wambua, S., Irungu, E., Mandaliya, K., Temmerman, M., Ryan, C., Mohamed, Y., et al. (2019). Type-Specific Human Papillomavirus Prevalence, Incident Cases, Persistence, and Associated Pregnancy Outcomes Among HIV-Infected Women in Kenya. Sexually Transmitted Diseases, 532–539.
Chicago author-date
Vyankandondera, Joseph, Sammy Wambua, Eunice Irungu, Kishorchandra Mandaliya, Marleen Temmerman, Claire Ryan, Yasmin Mohamed, et al. 2019. “Type-Specific Human Papillomavirus Prevalence, Incident Cases, Persistence, and Associated Pregnancy Outcomes Among HIV-Infected Women in Kenya.” Sexually Transmitted Diseases: 532–539.
Chicago author-date (all authors)
Vyankandondera, Joseph, Sammy Wambua, Eunice Irungu, Kishorchandra Mandaliya, Marleen Temmerman, Claire Ryan, Yasmin Mohamed, Davy Vanden Broeck, Rita Verhelst, Matthew Chersich, and Stanley Lüchters. 2019. “Type-Specific Human Papillomavirus Prevalence, Incident Cases, Persistence, and Associated Pregnancy Outcomes Among HIV-Infected Women in Kenya.” Sexually Transmitted Diseases: 532–539.
Vancouver
1.
Vyankandondera J, Wambua S, Irungu E, Mandaliya K, Temmerman M, Ryan C, et al. Type-Specific Human Papillomavirus Prevalence, Incident Cases, Persistence, and Associated Pregnancy Outcomes Among HIV-Infected Women in Kenya. Sexually Transmitted Diseases. 2019;532–9.
IEEE
[1]
J. Vyankandondera et al., “Type-Specific Human Papillomavirus Prevalence, Incident Cases, Persistence, and Associated Pregnancy Outcomes Among HIV-Infected Women in Kenya,” Sexually Transmitted Diseases, pp. 532–539, 2019.
@article{8624180,
  abstract     = {BACKGROUND: 
Persistent infection with high-risk types of human papillomavirus (HPV) is the preeminent factor driving the development of cervical cancer. There are large gaps in knowledge about both the role of pregnancy in the natural history of HPV infection and the impact of HPV on pregnancy outcomes.
METHODS: 
This single-site prospective cohort substudy, nested within an international multisite randomized controlled trial, assessed prevalence, incident cases, and persistence of type-specific HPV infection, and the association between persistence of high-risk HPV infection with pregnancy outcomes among HIV-infected pregnant women in Kenya, including HIV transmission to infants. Type-specific HPV was assessed using a line probe assay in pregnancy and again at 3 months after delivery. HIV status of children was determined using polymerase chain reaction at 6 weeks.
RESULTS: 
In total, 84.1% (206/245) of women had a high-risk HPV infection at enrollment. Three quarters (157/206) of these infections persisted postpartum. Persistence of HPV16 and/or HPV18 types was observed in more than half (53.4%; 39/73) of women with this infection at enrollment. Almost two-thirds had an incident high-risk HPV infection postpartum, which was not present in pregnancy (62.5%), most commonly HPV52 (19.0%). After adjustments, no association was detected between persistent high-risk HPV and preterm birth. All mothers of the 7 cases of infant HIV infection had persistent high-risk HPV infection (P = 0.044).
CONCLUSIONS: 
High levels of high-risk HPV infection and type-specific persistence were documented, heightening the urgency of mass role out of HPV vaccination. The association between HPV persistence and HIV transmission is a novel finding, warranting further study.},
  author       = {Vyankandondera, Joseph and Wambua, Sammy and Irungu, Eunice and Mandaliya, Kishorchandra and Temmerman, Marleen and Ryan, Claire and Mohamed, Yasmin and Vanden Broeck, Davy and Verhelst, Rita and Chersich, Matthew and Lüchters, Stanley},
  issn         = {0148-5717},
  journal      = {Sexually Transmitted Diseases},
  keywords     = {Public Health,Environmental and Occupational Health,Microbiology (medical),Infectious Diseases,Dermatology},
  language     = {eng},
  pages        = {532--539},
  title        = {Type-Specific Human Papillomavirus Prevalence, Incident Cases, Persistence, and Associated Pregnancy Outcomes Among HIV-Infected Women in Kenya},
  url          = {http://dx.doi.org/10.1097/olq.0000000000001029},
  year         = {2019},
}

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