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Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development

(2019) VACCINE. 37(34). p.4787-4793
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Abstract
The generation of robust systemic and mucosal antibody and cell-mediated immune (CMI) responses that are protective, long-lasting, and can quickly be recalled upon subsequent re-exposure to the cognate antigen is the key to the development of effective vaccine candidates. These responses, whether they represent mechanistic or non-mechanistic immunological correlates of protection, usually entail the activation of T cell memory and effector subsets (T-CMI) and induction of long-lasting memory B cells. However, for ETEC and Shigella, the precise role of these key immune cells in primary and secondary (anamnestic) immune responses remains ill-defined. A workshop to address immune correlates for ETEC and Shigella, in general, and to elucidate the mechanistic role of T-cell subsets and B-cells, both systemically and in the mucosal microenvironment, in the development of durable protective immunity against ETEC and Shigella was held at the recent 2nd Vaccines against Shigella and ETEC (VASE) conference in June 2018. This report is a summary of the presentations and the discussion that ensued at the workshop. (C) 2019 The Authors. Published by Elsevier Ltd.
Keywords
Immunocorrelate, Enterotoxigenic, Escherichia coli (ETEC), Shigella, T cells, B cells, Mucosal antibodies, IgA, IgG, Correlates of protection (CoP), ENTEROTOXIGENIC ESCHERICHIA-COLI, O-SPECIFIC POLYSACCHARIDE, RESEARCH-AND-DEVELOPMENT, FLEXNERI 2A, ANTIBODY-RESPONSES, CONJUGATE VACCINE, DOUBLE-BLIND, SERUM ANTIBODIES, ORAL VACCINE, SAFETY

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MLA
Mani, Sachin, et al. “Role of Antigen Specific T and B Cells in Systemic and Mucosal Immune Responses in ETEC and Shigella Infections, and Their Potential to Serve as Correlates of Protection in Vaccine Development.” VACCINE, vol. 37, no. 34, 2019, pp. 4787–93, doi:10.1016/j.vaccine.2019.03.040.
APA
Mani, S., Toapanta, F. R., McArthur, M. A., Qadri, F., Svennerholm, A.-M., Devriendt, B., … Sztein, M. B. (2019). Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development. VACCINE, 37(34), 4787–4793. https://doi.org/10.1016/j.vaccine.2019.03.040
Chicago author-date
Mani, Sachin, Franklin R Toapanta, Monica A McArthur, Firdausi Qadri, Ann-Mari Svennerholm, Bert Devriendt, Armelle Phalipon, Daniel Cohen, and Marcelo B Sztein. 2019. “Role of Antigen Specific T and B Cells in Systemic and Mucosal Immune Responses in ETEC and Shigella Infections, and Their Potential to Serve as Correlates of Protection in Vaccine Development.” VACCINE 37 (34): 4787–93. https://doi.org/10.1016/j.vaccine.2019.03.040.
Chicago author-date (all authors)
Mani, Sachin, Franklin R Toapanta, Monica A McArthur, Firdausi Qadri, Ann-Mari Svennerholm, Bert Devriendt, Armelle Phalipon, Daniel Cohen, and Marcelo B Sztein. 2019. “Role of Antigen Specific T and B Cells in Systemic and Mucosal Immune Responses in ETEC and Shigella Infections, and Their Potential to Serve as Correlates of Protection in Vaccine Development.” VACCINE 37 (34): 4787–4793. doi:10.1016/j.vaccine.2019.03.040.
Vancouver
1.
Mani S, Toapanta FR, McArthur MA, Qadri F, Svennerholm A-M, Devriendt B, et al. Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development. VACCINE. 2019;37(34):4787–93.
IEEE
[1]
S. Mani et al., “Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development,” VACCINE, vol. 37, no. 34, pp. 4787–4793, 2019.
@article{8623941,
  abstract     = {The generation of robust systemic and mucosal antibody and cell-mediated immune (CMI) responses that are protective, long-lasting, and can quickly be recalled upon subsequent re-exposure to the cognate antigen is the key to the development of effective vaccine candidates. These responses, whether they represent mechanistic or non-mechanistic immunological correlates of protection, usually entail the activation of T cell memory and effector subsets (T-CMI) and induction of long-lasting memory B cells. However, for ETEC and Shigella, the precise role of these key immune cells in primary and secondary (anamnestic) immune responses remains ill-defined. A workshop to address immune correlates for ETEC and Shigella, in general, and to elucidate the mechanistic role of T-cell subsets and B-cells, both systemically and in the mucosal microenvironment, in the development of durable protective immunity against ETEC and Shigella was held at the recent 2nd Vaccines against Shigella and ETEC (VASE) conference in June 2018. This report is a summary of the presentations and the discussion that ensued at the workshop. (C) 2019 The Authors. Published by Elsevier Ltd.},
  author       = {Mani, Sachin and Toapanta, Franklin R and McArthur, Monica A and Qadri, Firdausi and Svennerholm, Ann-Mari and Devriendt, Bert and Phalipon, Armelle and Cohen, Daniel and Sztein, Marcelo B},
  issn         = {0264-410X},
  journal      = {VACCINE},
  keywords     = {Immunocorrelate,Enterotoxigenic,Escherichia coli (ETEC),Shigella,T cells,B cells,Mucosal antibodies,IgA,IgG,Correlates of protection (CoP),ENTEROTOXIGENIC ESCHERICHIA-COLI,O-SPECIFIC POLYSACCHARIDE,RESEARCH-AND-DEVELOPMENT,FLEXNERI 2A,ANTIBODY-RESPONSES,CONJUGATE VACCINE,DOUBLE-BLIND,SERUM ANTIBODIES,ORAL VACCINE,SAFETY},
  language     = {eng},
  number       = {34},
  pages        = {4787--4793},
  title        = {Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2019.03.040},
  volume       = {37},
  year         = {2019},
}

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