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Inflammasomes in neuroinflammatory and neurodegenerative diseases

Sofie Voet (UGent) , Sahana Srinivasan (UGent) , Mohamed Lamkanfi (UGent) and Geert van Loo (UGent)
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Abstract
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well as host-derived danger signals. Upon activation, they induce an innate immune response by secreting the inflammatory cytokines interleukin (IL)-1 beta and IL-18, and additionally by inducing pyroptosis, a lytic cell death mode that releases additional inflammatory mediators. Microglia are the prominent innate immune cells in the brain for inflammasome activation. However, additional CNS-resident cell types including astrocytes and neurons, as well as infiltrating myeloid cells from the periphery, express and activate inflammasomes. In this review, we will discuss current understanding of the role of inflammasomes in common degenerative diseases of the brain and highlight inflammasome-targeted strategies that may potentially treat these diseases.
Keywords
TRAUMATIC BRAIN-INJURY, INTERLEUKIN-1-BETA CONVERTING-ENZYME, NLRP3, INFLAMMASOME, CEREBROSPINAL-FLUID, AMYLOID-BETA, MOUSE MODEL, AUTOIMMUNE, ENCEPHALOMYELITIS, CASPASE-1 AUTOPROTEOLYSIS, ALZHEIMERS-DISEASE, NALP3, INFLAMMASOME, disease, inflammasome, inflammation, microglia, neurodegeneration

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Citation

Please use this url to cite or link to this publication:

MLA
Voet, Sofie et al. “Inflammasomes in Neuroinflammatory and Neurodegenerative Diseases.” EMBO MOLECULAR MEDICINE 11.6 (2019): n. pag. Print.
APA
Voet, Sofie, Srinivasan, S., Lamkanfi, M., & van Loo, G. (2019). Inflammasomes in neuroinflammatory and neurodegenerative diseases. EMBO MOLECULAR MEDICINE, 11(6).
Chicago author-date
Voet, Sofie, Sahana Srinivasan, Mohamed Lamkanfi, and Geert van Loo. 2019. “Inflammasomes in Neuroinflammatory and Neurodegenerative Diseases.” Embo Molecular Medicine 11 (6).
Chicago author-date (all authors)
Voet, Sofie, Sahana Srinivasan, Mohamed Lamkanfi, and Geert van Loo. 2019. “Inflammasomes in Neuroinflammatory and Neurodegenerative Diseases.” Embo Molecular Medicine 11 (6).
Vancouver
1.
Voet S, Srinivasan S, Lamkanfi M, van Loo G. Inflammasomes in neuroinflammatory and neurodegenerative diseases. EMBO MOLECULAR MEDICINE. Hoboken: Wiley; 2019;11(6).
IEEE
[1]
S. Voet, S. Srinivasan, M. Lamkanfi, and G. van Loo, “Inflammasomes in neuroinflammatory and neurodegenerative diseases,” EMBO MOLECULAR MEDICINE, vol. 11, no. 6, 2019.
@article{8622890,
  abstract     = {Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well as host-derived danger signals. Upon activation, they induce an innate immune response by secreting the inflammatory cytokines interleukin (IL)-1 beta and IL-18, and additionally by inducing pyroptosis, a lytic cell death mode that releases additional inflammatory mediators. Microglia are the prominent innate immune cells in the brain for inflammasome activation. However, additional CNS-resident cell types including astrocytes and neurons, as well as infiltrating myeloid cells from the periphery, express and activate inflammasomes. In this review, we will discuss current understanding of the role of inflammasomes in common degenerative diseases of the brain and highlight inflammasome-targeted strategies that may potentially treat these diseases.},
  articleno    = {e10248},
  author       = {Voet, Sofie and Srinivasan, Sahana and Lamkanfi, Mohamed and van Loo, Geert},
  issn         = {1757-4676},
  journal      = {EMBO MOLECULAR MEDICINE},
  keywords     = {TRAUMATIC BRAIN-INJURY,INTERLEUKIN-1-BETA CONVERTING-ENZYME,NLRP3,INFLAMMASOME,CEREBROSPINAL-FLUID,AMYLOID-BETA,MOUSE MODEL,AUTOIMMUNE,ENCEPHALOMYELITIS,CASPASE-1 AUTOPROTEOLYSIS,ALZHEIMERS-DISEASE,NALP3,INFLAMMASOME,disease,inflammasome,inflammation,microglia,neurodegeneration},
  language     = {eng},
  number       = {6},
  pages        = {16},
  publisher    = {Wiley},
  title        = {Inflammasomes in neuroinflammatory and neurodegenerative diseases},
  url          = {http://dx.doi.org/10.15252/emmm.201810248},
  volume       = {11},
  year         = {2019},
}

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