Advanced search
1 file | 1.24 MB Add to list

The association of functional status with mortality and dialysis modality change : results from the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS)

Author
Organization
Abstract
BACKGROUND: Little is known about the prevalence of functional impairment in peritoneal dialysis (PD) patients, its variation by country, and its association with mortality or transfer to hemodialysis. METHODS: A prospective cohort study was conducted in PD patients from 7 countries in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) (2014 - 2017). Functional status (FS) was assessed by combining self-reports of 8 instrumental and 5 basic activities of daily living, using the Lawton-Brody and the Katz questionnaires. Summary FS scores, ranging from 1.25 (most dependent) to 13 (independent), were based on the patient's ability to perform each activity with or without assistance. Logistic regression was used to estimate the odds ratio (OR; 95% confidence interval [CI]) of a FS score < 11 comparing each country with the United States (US). Cox regression was used to estimate the hazard ratio (HR; 95% CI) for the effect of a low FS score on mortality and transfer to hemodialysis, adjusting for case mix. RESULTS: Of 2,593 patients with complete data on FS, 48% were fully independent (FS = 13), 32% had a FS score 11 to < 13, 14% had a FS score 8 to < 11, and 6% had a FS score < 8. Relative to the US, low FS scores (< 11; more dependent) were more frequent in Thailand (OR = 10.48, 5.90 - 18.60) and the United Kingdom (UK) (OR = 3.29, 1.77 - 6.08), but similar in other PDOPPS countries. The FS score was inversely and monotonically associated with mortality but not with transfer to hemodialysis; the HR, comparing a FS score < 8 vs 13, was 4.01 (2.44 - 6.61) for mortality and 0.91 (0.58 - 1.43) for transfer to hemodialysis. CONCLUSION: Regional differences in FS scores observed across PDOPPS countries may have been partly due to differences in regional patient selection for PD. Functional impairment was associated with mortality but not with permanent transfer to hemodialysis.
Keywords
QUALITY-OF-LIFE, ELDERLY-PATIENTS, DECISION-MAKING, OLDER PATIENTS, LONG-TERM, CARE, ADULTS, RISK, HOSPITALIZATION, HEMODIALYSIS, Daily activities, functional impairment, hemodialysis, survival

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.24 MB

Citation

Please use this url to cite or link to this publication:

MLA
Tennankore, Karthik, et al. “The Association of Functional Status with Mortality and Dialysis Modality Change : Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS).” PERITONEAL DIALYSIS INTERNATIONAL, vol. 39, no. 2, 2019, pp. 103–11.
APA
Tennankore, K., Zhao, J., Karaboyas, A., Bieber, B. A., Robinson, B. M., Morgenstern, H., … Teitelbaum, I. (2019). The association of functional status with mortality and dialysis modality change : results from the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS). PERITONEAL DIALYSIS INTERNATIONAL, 39(2), 103–111.
Chicago author-date
Tennankore, Karthik, Junhui Zhao, Angelo Karaboyas, Brian A Bieber, Bruce M Robinson, Hal Morgenstern, S Vanita Jassal, et al. 2019. “The Association of Functional Status with Mortality and Dialysis Modality Change : Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS).” PERITONEAL DIALYSIS INTERNATIONAL 39 (2): 103–11.
Chicago author-date (all authors)
Tennankore, Karthik, Junhui Zhao, Angelo Karaboyas, Brian A Bieber, Bruce M Robinson, Hal Morgenstern, S Vanita Jassal, Fredric O Finkelstein, Talerngsak Kanjanabuch, Areewan Cheawchanwattana, Ronald L Pisoni, James A Sloand, Jeffrey Perl, on behalf of the PDOPPS patient support working group, David Johnson, Mauricio Sanabria, Hideki Kawanishi, Yong-Lim Kim, Simon Davies, Angelito Bernardo, Ron Pisoni, Bruce Robinson, Jenny Shen, Sunil Badve, Neil Boudville, Fiona Brown, Josephine Chow, John Collins, Rachael Morton, Scott Wilson, Andreas Vychytil, Wim Van Biesen, Ana Figueiredo, Thyago de Moraes, Gillian Brunier, Arsh Jain, Vanita Jassal, Sharon Nessim, Matthew Oliver, Valerie Price, Rob Quinn, CC Szeto, Angela Wang, Mizuya Fukasawa, Yasuhiko Ito, Munekazu Ryuzaki, Tadashi Tomo, Alfonso Cueto Manzano, Mark Marshall, Susanne Ljungman, Sarinya Boongird, Chanchana Boonyakrai, Guttiga Halue, Suchai Sritippayawan, Sajja Tatiyanupanwong, Kriang Tungsanga, Elaine Bowes, Edwina Brown, Richard Fluck, Bak Leong Goh, Helen Hurst, Martin Wilkie, Graham Woodrow, Filitsa Bender, Judith Bernardini, Dinesh Chatoth, John Crabtree, Fred Finkelstein, Arshia Ghaffari, Rajnish Mehrotra, Beth Piraino, Martin Schreiber, and Isaac Teitelbaum. 2019. “The Association of Functional Status with Mortality and Dialysis Modality Change : Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS).” PERITONEAL DIALYSIS INTERNATIONAL 39 (2): 103–111.
Vancouver
1.
Tennankore K, Zhao J, Karaboyas A, Bieber BA, Robinson BM, Morgenstern H, et al. The association of functional status with mortality and dialysis modality change : results from the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS). PERITONEAL DIALYSIS INTERNATIONAL. 2019;39(2):103–11.
IEEE
[1]
K. Tennankore et al., “The association of functional status with mortality and dialysis modality change : results from the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS),” PERITONEAL DIALYSIS INTERNATIONAL, vol. 39, no. 2, pp. 103–111, 2019.
@article{8622579,
  abstract     = {BACKGROUND: Little is known about the prevalence of functional impairment in peritoneal dialysis (PD) patients, its variation by country, and its association with mortality or transfer to hemodialysis. 
METHODS: A prospective cohort study was conducted in PD patients from 7 countries in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) (2014 - 2017). Functional status (FS) was assessed by combining self-reports of 8 instrumental and 5 basic activities of daily living, using the Lawton-Brody and the Katz questionnaires. Summary FS scores, ranging from 1.25 (most dependent) to 13 (independent), were based on the patient's ability to perform each activity with or without assistance. Logistic regression was used to estimate the odds ratio (OR; 95% confidence interval [CI]) of a FS score < 11 comparing each country with the United States (US). Cox regression was used to estimate the hazard ratio (HR; 95% CI) for the effect of a low FS score on mortality and transfer to hemodialysis, adjusting for case mix. 
RESULTS: Of 2,593 patients with complete data on FS, 48% were fully independent (FS = 13), 32% had a FS score 11 to < 13, 14% had a FS score 8 to < 11, and 6% had a FS score < 8. Relative to the US, low FS scores (< 11; more dependent) were more frequent in Thailand (OR = 10.48, 5.90 - 18.60) and the United Kingdom (UK) (OR = 3.29, 1.77 - 6.08), but similar in other PDOPPS countries. The FS score was inversely and monotonically associated with mortality but not with transfer to hemodialysis; the HR, comparing a FS score < 8 vs 13, was 4.01 (2.44 - 6.61) for mortality and 0.91 (0.58 - 1.43) for transfer to hemodialysis. 
CONCLUSION: Regional differences in FS scores observed across PDOPPS countries may have been partly due to differences in regional patient selection for PD. Functional impairment was associated with mortality but not with permanent transfer to hemodialysis.},
  author       = {Tennankore, Karthik and Zhao, Junhui and Karaboyas, Angelo and Bieber, Brian A and Robinson, Bruce M and Morgenstern, Hal and Jassal, S Vanita and Finkelstein, Fredric O and Kanjanabuch, Talerngsak and Cheawchanwattana, Areewan and Pisoni, Ronald L and Sloand, James A and Perl, Jeffrey and PDOPPS patient support working group, on behalf of the and Johnson, David and Sanabria, Mauricio and Kawanishi, Hideki and Kim, Yong-Lim and Davies, Simon and Bernardo, Angelito and Pisoni, Ron and Robinson, Bruce and Shen, Jenny and Badve, Sunil and Boudville, Neil and Brown, Fiona and Chow, Josephine and Collins, John and Morton, Rachael and Wilson, Scott and Vychytil, Andreas and Van Biesen, Wim and Figueiredo, Ana and de Moraes, Thyago and Brunier, Gillian and Jain, Arsh and Jassal, Vanita and Nessim, Sharon and Oliver, Matthew and Price, Valerie and Quinn, Rob and Szeto, CC and Wang, Angela and Fukasawa, Mizuya and Ito, Yasuhiko and Ryuzaki, Munekazu and Tomo, Tadashi and Cueto Manzano, Alfonso and Marshall, Mark and Ljungman, Susanne and Boongird, Sarinya and Boonyakrai, Chanchana and Halue, Guttiga and Sritippayawan, Suchai and Tatiyanupanwong, Sajja and Tungsanga, Kriang and Bowes, Elaine and Brown, Edwina and Fluck, Richard and Goh, Bak Leong and Hurst, Helen and Wilkie, Martin and Woodrow, Graham and Bender, Filitsa and Bernardini, Judith and Chatoth, Dinesh and Crabtree, John and Finkelstein, Fred and Ghaffari, Arshia and Mehrotra, Rajnish and Piraino, Beth and Schreiber, Martin and Teitelbaum, Isaac},
  issn         = {0896-8608},
  journal      = {PERITONEAL DIALYSIS INTERNATIONAL},
  keywords     = {QUALITY-OF-LIFE,ELDERLY-PATIENTS,DECISION-MAKING,OLDER PATIENTS,LONG-TERM,CARE,ADULTS,RISK,HOSPITALIZATION,HEMODIALYSIS,Daily activities,functional impairment,hemodialysis,survival},
  language     = {eng},
  number       = {2},
  pages        = {103--111},
  title        = {The association of functional status with mortality and dialysis modality change : results from the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS)},
  url          = {http://dx.doi.org/10.3747/pdi.2018.00094},
  volume       = {39},
  year         = {2019},
}

Altmetric
View in Altmetric
Web of Science
Times cited: