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Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome

Laura Muiño Mosquera (UGent) , Fre Bauters (UGent) , Karlien Dhondt (UGent) , Hans De Wilde (UGent) , Luc Jordaens (UGent) , Katya De Groote (UGent) , Daniël De Wolf (UGent) , Katrien Hertegonne (UGent) and Julie De Backer (UGent)
Author
Organization
Abstract
Background: Marfan syndrome (MFS) is an inherited connective tissue disorder characterized by ectopia lentis, aortic root dilation and dissection and specific skeletal features. Obstructive sleep apnea (OSA) in MFS has been described earlier but the prevalence and its relation with the cardiovascular risk is still controversial. This study aimed to further investigate these aspects. Methods: In this prospective longitudinal study, we performed an attended polysomnography in 40 MFS patients (60% women, 37 +/- 12.8 years) and evaluated several cardiovascular parameters through echocardiography, resting electrocardiogram, 24 hr-Holter monitoring and serum NT-ProBNP measurements. Results: We found that OSA was present in 42.5% of the patients and that higher body mass index was the most important factor associated with the presence of OSA. We observed that overweight was present in 27.5% of the patients in the whole cohort and in 55.6% if >40 years. Furthermore, when evaluating the impact of OSA on the cardiovascular system, we observed that patients with OSA tended to have higher systolic blood pressure, larger distal aortic diameters and a higher prevalence of ventricular arrhythmia. These differences were, however, not significant after adjusting for confounders. Conclusions: Our study shows a high prevalence of OSA and a high prevalence of overweight in MFS patients. We found some trends between OSA and cardiovascular features but we could not establish a solid association. Our study, however might be underpowered, and a multicenter collaborative study could be very useful to answer some important open questions.
Keywords
aortic aneurysm, aortic dissection, arrhythmia, cardiovascular risk, Marfan syndrome, sleep apnea, UPPER AIRWAY COLLAPSIBILITY, EHLERS-DANLOS-SYNDROME, QUALITY-OF-LIFE, ASSOCIATION, PRESSURE, MUTATION, RECOMMENDATIONS, HYPERTENSION, DILATATION, DISEASE

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MLA
Muiño Mosquera, Laura, et al. “Sleep Apnea and the Impact on Cardiovascular Risk in Patients with Marfan Syndrome.” MOLECULAR GENETICS & GENOMIC MEDICINE, vol. 7, no. 8, 2019.
APA
Muiño Mosquera, L., Bauters, F., Dhondt, K., De Wilde, H., Jordaens, L., De Groote, K., … De Backer, J. (2019). Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome. MOLECULAR GENETICS & GENOMIC MEDICINE, 7(8).
Chicago author-date
Muiño Mosquera, Laura, Fre Bauters, Karlien Dhondt, Hans De Wilde, Luc Jordaens, Katya De Groote, Daniël De Wolf, Katrien Hertegonne, and Julie De Backer. 2019. “Sleep Apnea and the Impact on Cardiovascular Risk in Patients with Marfan Syndrome.” MOLECULAR GENETICS & GENOMIC MEDICINE 7 (8).
Chicago author-date (all authors)
Muiño Mosquera, Laura, Fre Bauters, Karlien Dhondt, Hans De Wilde, Luc Jordaens, Katya De Groote, Daniël De Wolf, Katrien Hertegonne, and Julie De Backer. 2019. “Sleep Apnea and the Impact on Cardiovascular Risk in Patients with Marfan Syndrome.” MOLECULAR GENETICS & GENOMIC MEDICINE 7 (8).
Vancouver
1.
Muiño Mosquera L, Bauters F, Dhondt K, De Wilde H, Jordaens L, De Groote K, et al. Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome. MOLECULAR GENETICS & GENOMIC MEDICINE. 2019;7(8).
IEEE
[1]
L. Muiño Mosquera et al., “Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome,” MOLECULAR GENETICS & GENOMIC MEDICINE, vol. 7, no. 8, 2019.
@article{8621325,
  abstract     = {Background: Marfan syndrome (MFS) is an inherited connective tissue disorder characterized by ectopia lentis, aortic root dilation and dissection and specific skeletal features. Obstructive sleep apnea (OSA) in MFS has been described earlier but the prevalence and its relation with the cardiovascular risk is still controversial. This study aimed to further investigate these aspects.
Methods: In this prospective longitudinal study, we performed an attended polysomnography in 40 MFS patients (60% women, 37 +/- 12.8 years) and evaluated several cardiovascular parameters through echocardiography, resting electrocardiogram, 24 hr-Holter monitoring and serum NT-ProBNP measurements.
Results: We found that OSA was present in 42.5% of the patients and that higher body mass index was the most important factor associated with the presence of OSA. We observed that overweight was present in 27.5% of the patients in the whole cohort and in 55.6% if >40 years. Furthermore, when evaluating the impact of OSA on the cardiovascular system, we observed that patients with OSA tended to have higher systolic blood pressure, larger distal aortic diameters and a higher prevalence of ventricular arrhythmia. These differences were, however, not significant after adjusting for confounders.
Conclusions: Our study shows a high prevalence of OSA and a high prevalence of overweight in MFS patients. We found some trends between OSA and cardiovascular features but we could not establish a solid association. Our study, however might be underpowered, and a multicenter collaborative study could be very useful to answer some important open questions.},
  articleno    = {e805},
  author       = {Muiño Mosquera, Laura and Bauters, Fre and Dhondt, Karlien and De Wilde, Hans and Jordaens, Luc and De Groote, Katya and De Wolf, Daniël and Hertegonne, Katrien and De Backer, Julie},
  issn         = {2324-9269},
  journal      = {MOLECULAR GENETICS & GENOMIC MEDICINE},
  keywords     = {aortic aneurysm,aortic dissection,arrhythmia,cardiovascular risk,Marfan syndrome,sleep apnea,UPPER AIRWAY COLLAPSIBILITY,EHLERS-DANLOS-SYNDROME,QUALITY-OF-LIFE,ASSOCIATION,PRESSURE,MUTATION,RECOMMENDATIONS,HYPERTENSION,DILATATION,DISEASE},
  language     = {eng},
  number       = {8},
  pages        = {12},
  title        = {Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome},
  url          = {http://dx.doi.org/10.1002/mgg3.805},
  volume       = {7},
  year         = {2019},
}

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