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Biological tests carried out on serum/plasma samples from donors of human body material for transplantation : Belgian experience and practical recommendations

(2018) CELL AND TISSUE BANKING. 19(4). p.681-695
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Abstract
This paper on the biological tests carried out on serum/plasma samples from donors of human body material (HBM) is the result of a project of the working Group of Superior Health Council of Belgium formed with experts in the field of HBM and infectious serology. Indeed, uncertainty about the interpretation of biological test results currently leads to the sometimes unjustified cancelling of planned donations or the rejection of harvested HBM, whilst more sophisticated diagnostic algorithms would still allow the use of organs or HBM that would otherwise have been rejected. NAT tests will not be discussed in this publication. In the first part some general aspects as the need for a formal agreement between the Tissue Establishment l and the laboratory responsible for the biological testing, but also some specifications regarding testing material, the choice of additional biological tests, and some general aspects concerning interpretation and reporting are discussed. In a second part, detailed information and recommendations concerning the interpretation are presented for each of the mandatory tests (human immunodeficiency virus, hepatitis B virus, hepatitis C virus and syphilis) is presented. A number of not mandatory, but regularly used optional serological tests (e.g. for the detection of antibodies to Toxoplasma gondii, Epstein-Barr virus, human T cell leukemia virus and cytomegalovirus) are also extensively discussed. Although the project was meant to provide clarification and recommendations concerning the Belgian legislation, the majority of recommendations are also applicable to testing of donors of tissues and cells in other (European) countries.
Keywords
Reporting, Interpretation, Biological test, Donor of human body material, IGG AVIDITY ASSAY, INFECTION, DIAGNOSIS, SYPHILIS, VIRUS, TOXOPLASMOSIS, GUIDELINES, HIV

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Citation

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MLA
Padalko, Elizaveta et al. “Biological Tests Carried Out on Serum/plasma Samples from Donors of Human Body Material for Transplantation : Belgian Experience and Practical Recommendations.” CELL AND TISSUE BANKING 19.4 (2018): 681–695. Print.
APA
Padalko, E., Lagrou, K., Delforge, M.-L., Jansens, H., Ectors, N., Pirnay, J.-P., Klykens, J., et al. (2018). Biological tests carried out on serum/plasma samples from donors of human body material for transplantation : Belgian experience and practical recommendations. CELL AND TISSUE BANKING, 19(4), 681–695.
Chicago author-date
Padalko, Elizaveta, Katrien Lagrou, Marie-Luce Delforge, Hilde Jansens, Nadine Ectors, Jean-Paul Pirnay, Johan Klykens, et al. 2018. “Biological Tests Carried Out on Serum/plasma Samples from Donors of Human Body Material for Transplantation : Belgian Experience and Practical Recommendations.” Cell and Tissue Banking 19 (4): 681–695.
Chicago author-date (all authors)
Padalko, Elizaveta, Katrien Lagrou, Marie-Luce Delforge, Hilde Jansens, Nadine Ectors, Jean-Paul Pirnay, Johan Klykens, Etienne Sokal, Ludo Muylle, Agnes Libois, Alain Vanderkelen, Gilbert Verbeken, Conny Matthys, Dominique Goossens, Geert Hanssens, Muriel Baltes, and Hilde Beele. 2018. “Biological Tests Carried Out on Serum/plasma Samples from Donors of Human Body Material for Transplantation : Belgian Experience and Practical Recommendations.” Cell and Tissue Banking 19 (4): 681–695.
Vancouver
1.
Padalko E, Lagrou K, Delforge M-L, Jansens H, Ectors N, Pirnay J-P, et al. Biological tests carried out on serum/plasma samples from donors of human body material for transplantation : Belgian experience and practical recommendations. CELL AND TISSUE BANKING. 2018;19(4):681–95.
IEEE
[1]
E. Padalko et al., “Biological tests carried out on serum/plasma samples from donors of human body material for transplantation : Belgian experience and practical recommendations,” CELL AND TISSUE BANKING, vol. 19, no. 4, pp. 681–695, 2018.
@article{8621030,
  abstract     = {This paper on the biological tests carried out on serum/plasma samples from donors of human body material (HBM) is the result of a project of the working Group of Superior Health Council of Belgium formed with experts in the field of HBM and infectious serology. Indeed, uncertainty about the interpretation of biological test results currently leads to the sometimes unjustified cancelling of planned donations or the rejection of harvested HBM, whilst more sophisticated diagnostic algorithms would still allow the use of organs or HBM that would otherwise have been rejected. NAT tests will not be discussed in this publication. In the first part some general aspects as the need for a formal agreement between the Tissue Establishment l and the laboratory responsible for the biological testing, but also some specifications regarding testing material, the choice of additional biological tests, and some general aspects concerning interpretation and reporting are discussed. In a second part, detailed information and recommendations concerning the interpretation are presented for each of the mandatory tests (human immunodeficiency virus, hepatitis B virus, hepatitis C virus and syphilis) is presented. A number of not mandatory, but regularly used optional serological tests (e.g. for the detection of antibodies to Toxoplasma gondii, Epstein-Barr virus, human T cell leukemia virus and cytomegalovirus) are also extensively discussed. Although the project was meant to provide clarification and recommendations concerning the Belgian legislation, the majority of recommendations are also applicable to testing of donors of tissues and cells in other (European) countries.},
  author       = {Padalko, Elizaveta and Lagrou, Katrien and Delforge, Marie-Luce and Jansens, Hilde and Ectors, Nadine and Pirnay, Jean-Paul and Klykens, Johan and Sokal, Etienne and Muylle, Ludo and Libois, Agnes and Vanderkelen, Alain and Verbeken, Gilbert and Matthys, Conny and Goossens, Dominique and Hanssens, Geert and Baltes, Muriel and Beele, Hilde},
  issn         = {1389-9333},
  journal      = {CELL AND TISSUE BANKING},
  keywords     = {Reporting,Interpretation,Biological test,Donor of human body material,IGG AVIDITY ASSAY,INFECTION,DIAGNOSIS,SYPHILIS,VIRUS,TOXOPLASMOSIS,GUIDELINES,HIV},
  language     = {eng},
  number       = {4},
  pages        = {681--695},
  title        = {Biological tests carried out on serum/plasma samples from donors of human body material for transplantation : Belgian experience and practical recommendations},
  url          = {http://dx.doi.org/10.1007/s10561-018-9721-2},
  volume       = {19},
  year         = {2018},
}

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