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Thermoresponsive DNA by intercalation of dsDNA with oligoethylene-glycol-functionalized small-molecule intercalators

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Abstract
Thermoresponsive polymeric materials are important building blocks for smart materials. In this work, the transformation of dsDNA into a thermoresponsive polymer is reported by intercalation of short, oligoethylene-glycol-modified proflavine intercalators. The thermoresponsiveness of the dsDNA-intercalator complex originates from the heating-induced dehydration of the ethylene glycol side chains, which leads to aggregation of the intercalated dsDNA. This work demonstrates the possibility of designing small-molecule intercalators to prepare thermoresponsive dsDNA complexes with tunable lower critical solution temperature behavior.
Keywords
POLYMERS, TEMPERATURE, BINDING, dsDNA, intercalation, lower critical solution temperature, thermoresponsive materials

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MLA
Bera, Debaditya, et al. “Thermoresponsive DNA by Intercalation of DsDNA with Oligoethylene-Glycol-Functionalized Small-Molecule Intercalators.” MACROMOLECULAR RAPID COMMUNICATIONS, vol. 40, no. 10, 2019.
APA
Bera, D., Verdonck, L., Glassner, M., Madder, A., & Hoogenboom, R. (2019). Thermoresponsive DNA by intercalation of dsDNA with oligoethylene-glycol-functionalized small-molecule intercalators. MACROMOLECULAR RAPID COMMUNICATIONS, 40(10).
Chicago author-date
Bera, Debaditya, Lars Verdonck, Mathias Glassner, Annemieke Madder, and Richard Hoogenboom. 2019. “Thermoresponsive DNA by Intercalation of DsDNA with Oligoethylene-Glycol-Functionalized Small-Molecule Intercalators.” MACROMOLECULAR RAPID COMMUNICATIONS 40 (10).
Chicago author-date (all authors)
Bera, Debaditya, Lars Verdonck, Mathias Glassner, Annemieke Madder, and Richard Hoogenboom. 2019. “Thermoresponsive DNA by Intercalation of DsDNA with Oligoethylene-Glycol-Functionalized Small-Molecule Intercalators.” MACROMOLECULAR RAPID COMMUNICATIONS 40 (10).
Vancouver
1.
Bera D, Verdonck L, Glassner M, Madder A, Hoogenboom R. Thermoresponsive DNA by intercalation of dsDNA with oligoethylene-glycol-functionalized small-molecule intercalators. MACROMOLECULAR RAPID COMMUNICATIONS. 2019;40(10).
IEEE
[1]
D. Bera, L. Verdonck, M. Glassner, A. Madder, and R. Hoogenboom, “Thermoresponsive DNA by intercalation of dsDNA with oligoethylene-glycol-functionalized small-molecule intercalators,” MACROMOLECULAR RAPID COMMUNICATIONS, vol. 40, no. 10, 2019.
@article{8620837,
  abstract     = {{Thermoresponsive polymeric materials are important building blocks for smart materials. In this work, the transformation of dsDNA into a thermoresponsive polymer is reported by intercalation of short, oligoethylene-glycol-modified proflavine intercalators. The thermoresponsiveness of the dsDNA-intercalator complex originates from the heating-induced dehydration of the ethylene glycol side chains, which leads to aggregation of the intercalated dsDNA. This work demonstrates the possibility of designing small-molecule intercalators to prepare thermoresponsive dsDNA complexes with tunable lower critical solution temperature behavior.}},
  articleno    = {{1800900}},
  author       = {{Bera, Debaditya and Verdonck, Lars and Glassner, Mathias and Madder, Annemieke and Hoogenboom, Richard}},
  issn         = {{1022-1336}},
  journal      = {{MACROMOLECULAR RAPID COMMUNICATIONS}},
  keywords     = {{POLYMERS,TEMPERATURE,BINDING,dsDNA,intercalation,lower critical solution temperature,thermoresponsive materials}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{5}},
  title        = {{Thermoresponsive DNA by intercalation of dsDNA with oligoethylene-glycol-functionalized small-molecule intercalators}},
  url          = {{http://dx.doi.org/10.1002/marc.201800900}},
  volume       = {{40}},
  year         = {{2019}},
}

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