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Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) IMMUNITY. 50(5). p.1149-1162
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Abstract
Nearly every tissue in the body undergoes routine turnover of cells as part of normal healthy living. The majority of these cells undergoing turnover die via apoptosis, and then are rapidly removed by phagocytes by the process of efferocytosis that is anti-inflammatory. However, a number of pathologies have recently been linked to defective clearance of apoptotic cells. Perturbed clearance arises for many reasons, including overwhelming of the clearance machinery, disruptions at different stages of efferocytosis, and responses of phagocytes during efferocytosis, all of which can alter the homeostatic tissue environment. This review covers linkages of molecules involved in the different phases of efferocytosis to disease pathologies that can arise due to their loss or altered function.
Keywords
DENSITY-LIPOPROTEIN RECEPTOR, GLYCATION END-PRODUCTS, APOPTOTIC CELL, CLEARANCE, PANNEXIN 1 CHANNELS, ALPHA-V INTEGRINS, FIND-ME SIGNAL, EARLY, ATHEROSCLEROSIS, CONTINUED CLEARANCE, TYROSINE KINASES, EPITHELIAL-CELLS

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Citation

Please use this url to cite or link to this publication:

Chicago
Morioka, Sho, Christian Maueröder, and Kodi Ravichandran. 2019. “Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology.” Immunity 50 (5): 1149–1162.
APA
Morioka, S., Maueröder, C., & Ravichandran, K. (2019). Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology. IMMUNITY, 50(5), 1149–1162.
Vancouver
1.
Morioka S, Maueröder C, Ravichandran K. Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology. IMMUNITY. Cambridge: Cell Press; 2019;50(5):1149–62.
MLA
Morioka, Sho, Christian Maueröder, and Kodi Ravichandran. “Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology.” IMMUNITY 50.5 (2019): 1149–1162. Print.
@article{8618313,
  abstract     = {Nearly every tissue in the body undergoes routine turnover of cells as part of normal healthy living. The majority of these cells undergoing turnover die via apoptosis, and then are rapidly removed by phagocytes by the process of efferocytosis that is anti-inflammatory. However, a number of pathologies have recently been linked to defective clearance of apoptotic cells. Perturbed clearance arises for many reasons, including overwhelming of the clearance machinery, disruptions at different stages of efferocytosis, and responses of phagocytes during efferocytosis, all of which can alter the homeostatic tissue environment. This review covers linkages of molecules involved in the different phases of efferocytosis to disease pathologies that can arise due to their loss or altered function.},
  author       = {Morioka, Sho and Maueröder, Christian and Ravichandran, Kodi},
  issn         = {1074-7613},
  journal      = {IMMUNITY},
  keywords     = {DENSITY-LIPOPROTEIN RECEPTOR,GLYCATION END-PRODUCTS,APOPTOTIC CELL,CLEARANCE,PANNEXIN 1 CHANNELS,ALPHA-V INTEGRINS,FIND-ME SIGNAL,EARLY,ATHEROSCLEROSIS,CONTINUED CLEARANCE,TYROSINE KINASES,EPITHELIAL-CELLS},
  language     = {eng},
  number       = {5},
  pages        = {1149--1162},
  publisher    = {Cell Press},
  title        = {Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology},
  url          = {http://dx.doi.org/10.1016/j.immuni.2019.04.018},
  volume       = {50},
  year         = {2019},
}

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